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Selection of Functional Intracellular Nanobodies
SLAS Discovery, 2019 Camelid-derived nanobodies are versatile tools for research, diagnostics, and therapeutics. Certain nanobodies can function as intrabodies and bind antigens within the eukaryotic cytosol. This capability is valuable for the development of intracellular probes and targeted gene therapies.
James Woods
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Nanobodies and Their Potential Applications
Nanomedicine, 2013Nanobodies are recombinant, antigen-specific, single-domain, variable fragments of camelid heavy chain-only antibodies. The innate supremacy of nanobodies as a renewable source of affinity reagents, together with their high production yield in a broad variety of expression systems, minimal size, great stability, reversible refolding and outstanding ...
Gholamreza Hassanzadeh-Ghassabeh +4 more
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Biotechnology Letters, 2020
Programmed death ligand 1 (PDL1, CD274, B7-H1) has been identified as the ligand for the immune inhibitory receptor programmed death 1 protein (PD1/PDCD1). PDL1 is a member of B7 family of immune molecules and this protein together with PDL2, are two ligands for PD1 expressed on activated lymphoid cells. By binding to PD1 on activated T cells, PDL1 may
Shufeng Li +6 more
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Programmed death ligand 1 (PDL1, CD274, B7-H1) has been identified as the ligand for the immune inhibitory receptor programmed death 1 protein (PD1/PDCD1). PDL1 is a member of B7 family of immune molecules and this protein together with PDL2, are two ligands for PD1 expressed on activated lymphoid cells. By binding to PD1 on activated T cells, PDL1 may
Shufeng Li +6 more
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Science Signaling
Antibody fragments can act as pharmacological tools to modulate the functions of G protein–coupled receptors.
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Antibody fragments can act as pharmacological tools to modulate the functions of G protein–coupled receptors.
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Trends in nanobody radiotheranostics
European Journal of Nuclear Medicine and Molecular ImagingAs the smallest antibody fragment with specific binding affinity, nanobody-based nuclear medicine has demonstrated significant potential to revolutionize the field of precision medicine, supported by burgeoning preclinical investigations and accumulating clinical evidence.
Xingru Long +4 more
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Nanobody-Based Chromatin Immunoprecipitation
2012Chromatin immunoprecipitation (ChIP), followed by microarray hybridization (ChIP-chip) or high-throughput sequencing (ChIP-seq), is becoming a widely used powerful method for the analysis of the in vivo DNA-protein interactions at genomic scale.The success of ChIP largely depends on the quality of antibodies.
NGUYEN DUC, Trong +5 more
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Optogenetic Activation of Intracellular Nanobodies
2022Intracellular antibody fragments such as nanobodies and scFvs are powerful tools for imaging and for modulating and neutralizing endogenous target proteins. Optogenetically activated intracellular antibodies (optobodies) constitute a light-inducible system to directly control intrabody activities in cells, with greater spatial and temporal resolution ...
Daseuli, Yu, Heo, Won Do
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Immuno-imaging using nanobodies
Current Opinion in Biotechnology, 2011Immuno-imaging is a developing technology that aims at studying disease in patients using imaging techniques such as positron emission tomography in combination with radiolabeled immunoglobulin derived targeting probes. Nanobodies are the smallest antigen-binding antibody-fragments and show fast and specific targeting in vivo.
Vaneycken, Ilse +7 more
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Nanobodies for NETosis Tracking and Visualization
Current ProtocolsAbstract Neutrophil extracellular traps (NETs) are pivotal in the immune response, trapping and neutralizing pathogens. The process of NET formation, or NETosis, is a critical innate immune response mechanism implicated in diverse physiological and pathological processes, including infections, chronic inflammation, and cancer ...
Nicoleta Gutu +3 more
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