Results 81 to 90 of about 19,553 (185)

Investigating the In Vivo Effects of Anti-Prion Protein Nanobodies on Prion Disease with AAV Vector

Pathogens
Prion diseases are fatal neurodegenerative disorders affecting humans and animals, and the central pathogenic event is the conversion of normal prion protein (PrPC) into the pathogenic PrPSc isoform.
Jingjing Zhang, Mengfei Wang, Dan Wang, Xiangyi Zhang, Yue Ma, Els Pardon, Jan Steyaert, Romany Abskharon, Fei Wang, Jiyan Ma   +9 more
doaj   +1 more source

Nanobodies: A new frontier in antiviral therapies

SLAS Discovery
Nanobodies, derived from the immune systems of camelids such as alpacas and llamas, represent a novel class of therapeutics with significant potential in fighting respiratory viral infections, such as SARS-CoV-2 and influenza.
Ahmed Mohammed, Mujahed I. Muustafa
doaj   +1 more source

Targeting endogenous proteins for degradation through the affinity-directed protein missile system [PDF]

, 2017
Targeted proteolysis of endogenous proteins is desirable as a research toolkit and in therapeutics. CRISPR/Cas9-mediated gene knockouts are irreversible and often not feasible for many genes.
Fulcher, Luke J., Hutchinson, Luke D., Macartney, Thomas J., Sapkota, Gopal P., Turnbull, Craig   +4 more
core   +2 more sources

Non-invasive assessment of murine PD-L1 levels in syngeneic tumor models by nuclear imaging with nanobody tracers [PDF]

, 2017
Blockade of the inhibitory PD-1/PD-L1 immune checkpoint axis is a promising cancer treatment. Nonetheless, a significant number of patients and malignancies do not respond to this therapy.
Breckpot, K, Broos, K, Devoogdt, N, Escors, D, Keyaerts, M, Lecocq, Q, Liston, A, Nguyen, T, Raes, G, Renmans, D   +9 more
core   +2 more sources

An Affinity-directed PROtein Missile (AdPROM) system for targeted proteolysis [PDF]

, 2016
The von Hippel-Lindau (VHL) protein serves to recruit the hypoxia inducible factor alpha (HIF1α) protein under normoxia to the CUL2 E3 ubiquitin ligase for its ubiquitylation and degradation through the proteasome.
Bozatzi, Polyxeni, Fulcher, Luke, Hornberger, Annika, Macartney, Thomas, Rojas-Fernandez, Alejandro, Sapkota, Gopal   +5 more
core   +3 more sources

Development of SNAP-Tag Based Nanobodies as Secondary Antibody Mimics for Indirect Immunofluorescence Assays

Cells
The immunofluorescence assay is widely used for cellular biology and diagnosis applications. Such an antigen–antibody detection system enables the assessment and visualization of the expression and localization of target proteins.
Wenjie Sheng, Chaoyu Zhang, T. M. Mohiuddin, Marwah Al-Rawe, Roland Schmitz, Marcus Niebert, Lutz Konrad, Steffen Wagner, Felix Zeppernick, Ivo Meinhold-Heerlein, Ahmad Fawzi Hussain   +10 more
doaj   +1 more source

Spontaneous emission rate of an excited atom placed near a nanofiber

, 2002
The spontaneous decay rates of an excited atom placed near a dielectric cylinder are investigated. A special attention is paid to the case when the cylinder radius is small in comparison with radiation wavelength (nanofiber or photonic wire).
't Hooft, Braginsky, Braginsky, Bykov, Chance, Chew, Collot, Fermi, Goy, Jhe, John, Klimov, Klimov, Klimov, Kocharovsky, Lagarkov, Lin, Mie, Pendry, Purcell, Sandoghdar, Shelby, Shelby, Smith, Smith, V.V. Klimov, Veselago, Yablonovich   +27 more
core   +1 more source

Nanoscopic compartmentalization of membrane protein motion at the axon initial segment [PDF]

, 2016
The axon initial segment (AIS) is enriched in specific adaptor, cytoskeletal, and transmembrane molecules. During AIS establishment, a membrane diffusion barrier is formed between the axonal and somatodendritic domains.
Albrecht, D, Ewers, H, Noé, F, Sadeghi, M, Tschager, T, Winterflood, CM   +5 more
core   +1 more source

Structure of the substrate-engaged SecA-SecY protein translocation machine. [PDF]

, 2019
The Sec61/SecY channel allows the translocation of many proteins across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma membrane.
Catipovic, Marco, Gao, Ning, Li, Long, Ma, Chengying, Park, Eunyong, Rapoport, Tom, Sun, Dongjie, Wu, Xiaofei   +7 more
core  

Seed produced anti ETEC antibodies for oral passive immunisation of piglets against post weaning diarrhoea [PDF]

, 2011
C
Coddens, Annelies, Cox, Eric, De Buck, Sylvie, De Greve, Henri, Depicker, Anna, Hofmeisterova, Hana, Virdi, Vikram   +6 more
core   +1 more source