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Identification of a Potential Inhibitor (MCULE-8777613195-0-12) of New Delhi Metallo-β-Lactamase-1 (NDM-1) Using In Silico and In Vitro Approaches

Molecules, 2022
New Delhi metallo-β-lactamase-1 (NDM-1), expressed in different Gram-negative bacteria, is a versatile enzyme capable of hydrolyzing β-lactam rings containing antibiotics such as penicillins, cephalosporins, and even carbapenems.
Ghazala Muteeb +5 more
doaj +1 more source

Clinical Course and Predictors of Biologic Therapy, Hospitalisation and Surgery: A Five‐Year Prospective Study in Newly Diagnosed Inflammatory Bowel Disease

Alimentary Pharmacology &Therapeutics, EarlyView.
In this large multicentre Spanish inception cohort, biologics/JAK inhibitors were frequently used during the first 5 years after inflammatory bowel disease diagnosis and were associated with reduced hospitalisation risk, although not with lower abdominal surgery rates.
Ana Garre +308 more
wiley +1 more source

The Ahlqvist Subphenotypes of Type 2 Diabetes: A Narrative Review of Scientific Evidence and Its Potential Contribution to Precision Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Among several approaches, k‐means clustering has established as a widely used method to classify people with type 2 diabetes (T2D) into distinct subphenotypes, and the Ahlqvist T2D subphenotypes of Severe Insulin Deficient Diabetes (SIDD), Mild Age‐Related Diabetes (MARD), Mild Obesity Diabetes (MOD) and Severe Insulin Resistant ...
Wolfgang Landgraf +3 more
wiley +1 more source

Genomic Insights into Carbapenem-Resistant Organisms Producing New Delhi Metallo-β-Lactamase in Live Poultry Markets

Microorganisms
New Delhi metallo-β-lactamase (NDM) is an enzyme that can degrade a wide range of β-lactam antibiotics. The widespread dissemination of the blaNDM gene, which encodes NDM, in animal-derived settings poses a threat to public health security.
Xueqiang Xin +5 more
doaj +1 more source

What Is the Clinical Periodontal Condition of Patients With Diabetes Mellitus as Compared to Those Without?—A Synthesis of Systematic Reviews

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Focused Question What is the clinical periodontal condition of patients with diabetes mellitus (DM) as compared to those without DM (NDM) as gathered from existing systematic reviews (SRs)? Methods MEDLINE‐PubMed and the Cochrane Library were searched from inception through September 2024 to identify eligible studies.
Lotte P. M. Weijdijk +3 more
wiley +1 more source

Shape of Water: Power Dynamics for Supply Chain Resilience

Journal of Supply Chain Management, EarlyView.
ABSTRACT The world is facing climate change‐driven disruptions such as extreme weather events, which affect nature as well as firms and their supply chains. Nonetheless, little is known about how supply chain players shape their socioecological resilience, including from a power perspective.
Aristides R. Oliveira Junior +3 more
wiley +1 more source

Mechanistic and Spectroscopic Studies of Metallo-β-lactamase NDM-1

, 2016
In an effort to biochemically characterize metallo-β-lactamase NDM-1, we cloned, overexpressed, purified, and characterized several maltose binding protein (MBP)–NDM-1 fusion proteins with different N-termini (full-length, Δ6, Δ21, and Δ36).
Michael W. Crowder (1319943) +5 more
core +1 more source

NDM-1-Positive K. pneumoniae at a Teaching Hospital in Southwestern China: Clinical Characteristics, Antimicrobial Resistance, Molecular Characterization, Biofilm Assay, and Virulence

Canadian Journal of Infectious Diseases and Medical Microbiology, 2020
Background. The emergence of the NDM-1-positive Klebsiella pneumoniae (K. pneumoniae) strains has led to limited therapeutic options for clinical treatment.
Kai Yang +6 more
doaj +1 more source

Detection of Carbapenem-resistant Enterobacteriaceae by Real-Time PCR and Assessment of Hospitalization Related Risk Factors Associated with their Fecal Carriage: A Case-control Study

Journal of Pure and Applied Microbiology, 2022
Opportunistic behavior of commensal bacteria during severe infection, especially of the intestine is always considered as a predisposing threat for the severely ill patient admitted to hospitals.
Ravikant +4 more
doaj +1 more source

Blue boost: Monochromatic blue light and blue‐enriched spectra (RBW) enhance physiology, bioactive compounds, and yield of strawberry in indoor vertical farming

Photochemistry and Photobiology, EarlyView.
Effects of spectral quality and light regime on the physiological, biochemical, and agronomic responses of strawberry plants grown in an indoor aeroponic system. Constant blue and red light and sinusoidal red and red–blue–white (RBW) light regimes differentially modulated photosynthetic performance, stomatal regulation, antioxidant metabolism, carbon ...
Carlos Henrique Pereira Bento +10 more
wiley +1 more source

medicine
carbapenemase
carbapenem resistance

ndm
antibiotic resistance
carbapenemases

incx3
escherichia coli