Results 101 to 110 of about 12,065 (211)

Podocytes: recent biomolecular developments

Biomolecular Concepts, 2014
Podocytes are postmitotic renal glomerular cells with multiple ramifications that extend from the cell body. Processes departing from a podocyte interdigitate with corresponding projections from neighboring cells and form an intricate web that enwraps ...
Armelloni Silvia, Corbelli Alessandro, Giardino Laura, Li Min, Ikehata Masami, Mattinzoli Deborah, Messa Piergiorgio, Pignatari Chiara, Watanabe Shojiro, Rastaldi Maria Pia   +9 more
doaj   +1 more source

Mutational analysis of the PLCE1 gene in steroid-resistant nephrotic syndrome [PDF]

, 2010
International audienceBackground: Mutations in the PLCE1 gene encoding phospholipase C epsilon 1 (PLCε1) have been recently described in patients with early-onset nephrotic syndrome (NS) and diffuse mesangial sclerosis (DMS).
Audrey Pawtowski, Audrey Pawtowski, Chantal Loirat, Constantinos J, Corinne Antignac, Et Al. Mu, Fabien Nevo, Fabien Nevo, Georges Deschênes, Hal Id Inserm, Ilmay Bilge, Kenza Soulami, Lisa M. Guay, Marie-alice Macher, Marie-claire Gubler, Michelle Hall, Olivia Boyer, Olivia Boyer, Olivier Gribouval, Olivier Gribouval, Robert Weiss, Zelal Bircan   +21 more
core   +7 more sources

Mapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes

Journal of Cellular Physiology, Volume 241, Issue 1, January 2026.
Abstract Preservation of the insulin‐sensitive glomerular podocyte is imperative for normal kidney function. The protein tyrosine phosphatases (PTPs), protein tyrosine phosphatase 1B (PTP1B), T‐cell protein tyrosine phosphatase (TCPTP), and Src homology phosphatase 2 (SHP2) are established regulators of insulin signaling in vivo and implicated in renal
Grace LeBleu, Ming‐Fo Hsu, Yoshihiro Ito, Suh‐Yuen Liang, Kwan‐Liu Ma, Tzu‐Ching Meng, Fawaz G. Haj   +6 more
wiley   +1 more source

Role of Protein Kinase C in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy [PDF]

, 2014
The early glomerular changes in diabetes include a podocyte phenotype with loss of slit diaphragm proteins, changes in the actin cytoskeleton and foot process architecture.
Beina Teng, Irini Tossidou, Mario Schiffer, Michelle Duong, Xuejiao Yu   +4 more
core   +2 more sources

Genetic ablation of calcium-independent phospholipase A2γ induces glomerular injury in mice [PDF]

, 2016
Glomerular visceral epithelial cells (podocytes) play a critical role in the maintenance of glomerular permselectivity. Podocyte injury, manifesting as proteinuria, is the cause of many glomerular diseases. We reported previously that calcium-independent
Aoudjit, Lamine, Cybulsky, Andrey V, Elimam, Hanan, Gross, Richard W, Guillemette, Julie, Kaufman, Daniel R, Papillon, Joan, Takano, Tomoko   +7 more
core   +2 more sources

A pilot study on genetic variation in purine-rich elements in the nephrin gene promoter in type 2 diabetic patients

Biological Research, 2007
Diabetic nephropathy (DN) is one of the major complications of type 2 diabetes and is associated with coronary disease. Nephrin, a protein mainly expressed in glomeruli, is decreased in DN and other kidney diseases.
RODRIGO GONZÁLEZ, ARES TIRADO, MONSERRAT BALANDA, MIRIAM ALVO, INÉS BARQUÍN, PILAR DURRUTY, SERGIO LOBOS, DANIELA SEELENFREUND   +7 more
doaj  

Protective Effects of Physalis angulata on Podocythopathies Through B-Cell-Activating Factor Inhibition in Doxorubicin-Induced Nephrotic Syndrome Rat Model

Biomedicines
Background/Objectives: Nephrotic syndrome, a glomerular disease caused by podocyte dysfunction, is characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia.
Astrid K. Kardani, Loeki E. Fitri, Nur Samsu, Krisni Subandiyah   +3 more
doaj   +1 more source

Detection of podocyturia in patients with lupus nephritis [PDF]

, 2013
INTRODUCTION: The podocyturia has been detected in glomerular diseases, such as lupus nephritis (LN), in which proteinuria is an important manifestation, and its occurrence seems to be limited to the active phase of the disease.
Mansur, Juliana Busato, Mastroianni Kirsztajn, Gianna, Nishida, Sonia Kiyomi, Sabino, Amelia Rodrigues Pereira, Sass, Nelson, Teixeira, Vicente de Paulo Castro   +5 more
core   +3 more sources

Proteinuria in Primary and Secondary Renal Diseases [PDF]

Journal of Clinical and Diagnostic Research, 2012
Proteinuria is a strong indicator of kidney disease. Various pathological conditions such as diabetes mellitus, cardiovascular disease and hypertension have been shown to provoke secondary kidney problems and significant proteinuria.
Anuradha B. Patil, C.V. B. Prasad, Shivaprasad S.   +2 more
doaj  

Role of Antibody Anti-AGE in the Expression of Nephrin and RAGE on Primary Glomerulus Cell Exposed with AGE

Journal of Tropical Life Science, 2017
Upregulation of nephrin expression occurs at the early stage of nephropathy and decrease in the period 6 months on hyperglycaemic condition. Nephrin is associated with the initial stage of the loss of the permeability barrier in diabetic nephropathy ...
Rudy Salam, Diana Lyrawati, Nur Samsu
doaj   +1 more source