Results 21 to 30 of about 12,068 (208)
CXCL16 and oxLDL are induced in the onset of diabetic nephropathy [PDF]
, 2009 Diabetic nephropathy (DN) is a major cause of end-stage renal failure worldwide. Oxidative stress has been reported to be a major culprit of the disease and increased oxidized low density lipoprotein (oxLDL) immune complexes were found in patients with ...
Abdel-Aziz, Abdel-Aziz H. +11 more
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Phosphorylation of nephrin induces phase separated domains that move through actomyosin contraction [PDF]
, 2019 © The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Kim, S., Kalappurakkal, J. M., Mayor, S., & Rosen, M. K.
Kalappurakkal, Joseph Mathew +3 more
core +1 more source
A new outlook towards kidney injuries [PDF]
, 2012 Acute and chronic progression of injury to the kidney leads to the failure of the renal system and has become an increasingly important cause of morbidity and mortality.
Abhijeet Satwekar, Mahesh Satwekar
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Cell Reports, 2012 Robo2 is the cell surface receptor for the repulsive guidance cue Slit and is involved in axon guidance and neuronal migration. Nephrin is a podocyte slit-diaphragm protein that functions in the kidney glomerular filtration barrier.
Xueping Fan +14 more
doaj +1 more source
Notch activates Wnt-4 signalling to control medio-lateral patterning of the pronephros [PDF]
, 2009 Previous studies have highlighted a role for the Notch signalling pathway during pronephrogenesis in the amphibian Xenopus laevis, and in nephron development in the mammalian metanephros, yet a mechanism for this function remains elusive.
Jones, E. A., Naylor, Richard William
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Journal of the American Society of Nephrology, 2012 It is difficult to conceive how podocytes establish slit diaphragms without nephrin, but a recent paper1 suggests that an entire class of vertebrates have podocytes that are able to do just that. Why did this discovery take so long, and why should it be surprising or exciting?
openaire +2 more sources
Factors Affecting Circulating mRNA for Nephrin [PDF]
Clinical Chemistry, 2005 Kidney disease affects more than 20 million individuals in the United States alone. Although the causes of kidney failure are diverse, the glomerular filtration barrier is often the target of injury. Identification of the type of disease is important for targeting therapy.
Emanuela, Orlandi +3 more
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Elevated Levels of Urinary Podocyte-Derived Microparticles in Nephrotic Syndrome
Indonesian Biomedical Journal, 2023 BACKGROUND: Nephrotic syndrome (NS) is the most common glomerular disease in childhood. The proposed hypothesis for the pathogenesis of this disease has changed over time, from immune dysregulation theory and systemic circulating factors theory, to the ...
Eka Laksmi Hidayati +6 more
doaj +1 more source
Whole carcass diets: a role for fibre in gastrointestinal health of cheetahs? [PDF]
, 2011 This study was undertaken to test the hypothesis that altered podocyte slit protein nephrin distribution is associated with disturbed polarity protein expressions in podocytes from preeclampsia (PE).
Depauw, Sarah +6 more
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Interaction with Podocin Facilitates Nephrin Signaling [PDF]
Journal of Biological Chemistry, 2001 Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid-resistant proteinuria. In addition, mice lacking CD2-associated protein (CD2AP) develop a nephrotic syndrome that resembles NPHS mutations suggesting that all three proteins are essential for the integrity of glomerular podocytes ...
Huber, Tobias B. +4 more
openaire +3 more sources