Results 51 to 60 of about 12,068 (208)

Characterization of novel glomerular proteins : role in physiology and disease [PDF]

, 2014
Glomerular damage accounts for the majority of chronic kidney disease cases, the prevalence of which is dramatically escalating worldwide, mainly due to increase in diabetes and associated nephropathy.
Andersson, Ann-Charlotte
core   +1 more source

Anion Exchanger 1 Interacts with Nephrin in Podocytes [PDF]

Journal of the American Society of Nephrology, 2010
The central role of the multifunctional protein nephrin within the macromolecular complex forming the glomerular slit diaphragm is well established, but the mechanisms linking the slit diaphragm to the cytoskeleton and to the signaling pathways involved in maintaining the integrity of the glomerular filter remain incompletely understood.
Wu, F, Saleem, M.A, Kampik, N.B, Satchwell, T.J, Williamson, R.C, Blattner, S.M, Ni, L, Toth, T, White, G, Young, M.T, Parker, M.D, Alper, S.L, Wagner, C.A, Toye, A.M   +13 more
openaire   +4 more sources

Urinary nephrin is earlier, more sensitive and specific marker of diabetic nephropathy than microalbuminuria [PDF]

Journal of Medical Biochemistry, 2020
Background: Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Progressive damage and decline in the number of podocytes often occur in the early stages of DN.
Kostovska Irena, Tosheska-Trajkovska Katerina, Topuzovska Sonja, Cekovska Svetlana, Spasovski Goce, Kostovski Ognen, Labudovic Danica   +6 more
doaj  

The effects of dual PPARα/γ agonism compared with ACE inhibition in the BTBRob/ob mouse model of diabetes and diabetic nephropathy [PDF]

, 2017
The leptin-deficient BTBRob/ob mouse develops progressive albuminuria and morphological lesions similar to human diabetic nephropathy (DN), although whether glomerular hyperfiltration, a recognized feature of early DN that may contribute to renal injury,
Böttcher, G, Ericsson, A, Hyberg, G, Johansson, C, Jönsson-Rylander, A-C, Lal, M, Sabirsh, A, Strömstedt, M, Tapani, S, Tonelius, P, Unwin, R, William-Olsson, L   +11 more
core   +1 more source

Notch Promotes Dynamin-Dependent Endocytosis of Nephrin [PDF]

Journal of the American Society of Nephrology, 2012
Notch signaling in podocytes causes proteinuria and glomerulosclerosis in humans and rodents, but the underlying mechanism remains unknown. Here, we analyzed morphologic, molecular, and cellular events before the onset of proteinuria in newborn transgenic mice that express activated Notch in podocytes.
Aoife M, Waters, Megan Yi Jun, Wu, Yi-Wei, Huang, Guang Ying, Liu, Doug, Holmyard, Tuncer, Onay, Nina, Jones, Sean E, Egan, Lisa A, Robinson, Tino D, Piscione   +9 more
openaire   +2 more sources

Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes

eLife, 2022
The kidneys generate about 180 l of primary urine per day by filtration of plasma. An essential part of the filtration barrier is the slit diaphragm, a multiprotein complex containing nephrin as major component.
Konrad Lang, Julian Milosavljevic, Helena Heinkele, Mengmeng Chen, Lea Gerstner, Dominik Spitz, Severine Kayser, Martin Helmstädter, Gerd Walz, Michael Köttgen, Andrew Spracklen, John Poulton, Tobias Hermle   +12 more
doaj   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Nephrin Signaling Results in Integrin β1 Activation [PDF]

Journal of the American Society of Nephrology, 2019
Significance Statement The slit diaphragm protein Nephrin, which is essential for an intact glomerular filter, signals from the podocyte slit diaphragm to the Actin cytoskeleton and induces lamellipodia formation. The authors present evidence that Nephrin activation results in activation of Integrin β1 in a cultured human ...
Christopher Philipp, Dlugos, Cara, Picciotto, Carolin, Lepa, Malte, Krakow, Antje, Stöber, Mee-Ling, Eddy, Thomas, Weide, Astrid, Jeibmann, Michael, P Krahn, Veerle, Van Marck, Jürgen, Klingauf, Andrea, Ricker, Roland, Wedlich-Söldner, Hermann, Pavenstädt, Christian, Klämbt, Britta, George   +15 more
openaire   +2 more sources

Replicated evidence for aminoacylase 3 and nephrin gene variations to predict antihypertensive drug responses [PDF]

, 2017
Peer ...
Donner, Kati M., Fyhrquist, Frej, Hiltunen, Timo P., Kontula, Kimmo K., Mohney, Rob, Rimpelä, Jenni M., Sarin, Antti-Pekka, Stirdivant, Steven, Tuiskula, Annukka M.   +8 more
core   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source