Results 51 to 60 of about 12,065 (211)

Urinary nephrin is earlier, more sensitive and specific marker of diabetic nephropathy than microalbuminuria [PDF]

Journal of Medical Biochemistry, 2020
Background: Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Progressive damage and decline in the number of podocytes often occur in the early stages of DN.
Kostovska Irena, Tosheska-Trajkovska Katerina, Topuzovska Sonja, Cekovska Svetlana, Spasovski Goce, Kostovski Ognen, Labudovic Danica   +6 more
doaj  

The effects of dual PPARα/γ agonism compared with ACE inhibition in the BTBRob/ob mouse model of diabetes and diabetic nephropathy [PDF]

, 2017
The leptin-deficient BTBRob/ob mouse develops progressive albuminuria and morphological lesions similar to human diabetic nephropathy (DN), although whether glomerular hyperfiltration, a recognized feature of early DN that may contribute to renal injury,
Böttcher, G, Ericsson, A, Hyberg, G, Johansson, C, Jönsson-Rylander, A-C, Lal, M, Sabirsh, A, Strömstedt, M, Tapani, S, Tonelius, P, Unwin, R, William-Olsson, L   +11 more
core   +1 more source

Notch Promotes Dynamin-Dependent Endocytosis of Nephrin [PDF]

Journal of the American Society of Nephrology, 2012
Notch signaling in podocytes causes proteinuria and glomerulosclerosis in humans and rodents, but the underlying mechanism remains unknown. Here, we analyzed morphologic, molecular, and cellular events before the onset of proteinuria in newborn transgenic mice that express activated Notch in podocytes.
Aoife M, Waters, Megan Yi Jun, Wu, Yi-Wei, Huang, Guang Ying, Liu, Doug, Holmyard, Tuncer, Onay, Nina, Jones, Sean E, Egan, Lisa A, Robinson, Tino D, Piscione   +9 more
openaire   +2 more sources

Nephrin Signaling Results in Integrin β1 Activation [PDF]

Journal of the American Society of Nephrology, 2019
Significance Statement The slit diaphragm protein Nephrin, which is essential for an intact glomerular filter, signals from the podocyte slit diaphragm to the Actin cytoskeleton and induces lamellipodia formation. The authors present evidence that Nephrin activation results in activation of Integrin β1 in a cultured human ...
Christopher Philipp, Dlugos, Cara, Picciotto, Carolin, Lepa, Malte, Krakow, Antje, Stöber, Mee-Ling, Eddy, Thomas, Weide, Astrid, Jeibmann, Michael, P Krahn, Veerle, Van Marck, Jürgen, Klingauf, Andrea, Ricker, Roland, Wedlich-Söldner, Hermann, Pavenstädt, Christian, Klämbt, Britta, George   +15 more
openaire   +2 more sources

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes

eLife, 2022
The kidneys generate about 180 l of primary urine per day by filtration of plasma. An essential part of the filtration barrier is the slit diaphragm, a multiprotein complex containing nephrin as major component.
Konrad Lang, Julian Milosavljevic, Helena Heinkele, Mengmeng Chen, Lea Gerstner, Dominik Spitz, Severine Kayser, Martin Helmstädter, Gerd Walz, Michael Köttgen, Andrew Spracklen, John Poulton, Tobias Hermle   +12 more
doaj   +1 more source

Replicated evidence for aminoacylase 3 and nephrin gene variations to predict antihypertensive drug responses [PDF]

, 2017
Peer ...
Donner, Kati M., Fyhrquist, Frej, Hiltunen, Timo P., Kontula, Kimmo K., Mohney, Rob, Rimpelä, Jenni M., Sarin, Antti-Pekka, Stirdivant, Steven, Tuiskula, Annukka M.   +8 more
core   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Nephrin sends us signals [PDF]

Kidney International, 2003
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openaire   +3 more sources

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source