Results 81 to 90 of about 12,068 (208)

Diverse Levels of Sequence Selectivity and Catalytic Efficiency of Protein-Tyrosine Phosphatases [PDF]

, 2014
The sequence selectivity of 14 classical protein-tyrosine phosphatases (PTPs) (PTPRA, PTPRB, PTPRC, PTPRD, PTPRO, PTP1B, SHP-1, SHP-2, HePTP, PTP-PEST, TCPTP, PTPH1, PTPD1, and PTPD2) was systematically profiled by screening their catalytic domains ...
Bell, Charles E., Chen, Xianwen, Knapp, Stefan, Luechapanichkul, Rinrada, Neel, Benjamin G., Pei, Dehua, Selner, Nicholas G., Zhang, Zhong-Yin   +7 more
core   +1 more source

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, Volume 16, Issue 1, Page 25-40, January 2026.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

Nephrin Promotes Cell-Cell Adhesion through Homophilic Interactions [PDF]

The American Journal of Pathology, 2003
Nephrin is a type-1 transmembrane protein and a key component of the podocyte slit diaphragm, the ultimate glomerular plasma filter. Genetic and acquired diseases affecting expression or function of nephrin lead to severe proteinuria and distortion or absence of the slit diaphragm.
Jamshid, Khoshnoodi, Kristmundur, Sigmundsson, Lars-Göran, Ofverstedt, Ulf, Skoglund, Björn, Obrink, Jorma, Wartiovaara, Karl, Tryggvason   +6 more
openaire   +2 more sources

Renal Implications of Psoriasis: Urinary Podocyte Markers and Disease Progression

Dermatology Practical & Conceptual
Introduction: Psoriasis may lead to glomerular inflammatory damage and disruption of the podocyte barrier, allowing podocyte degradation products to leak into the urine.
Sule Gencoglu, Meltem Yardim, Ramazan Fazil Akkoc   +2 more
doaj   +1 more source

Mapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes

Journal of Cellular Physiology, Volume 241, Issue 1, January 2026.
Abstract Preservation of the insulin‐sensitive glomerular podocyte is imperative for normal kidney function. The protein tyrosine phosphatases (PTPs), protein tyrosine phosphatase 1B (PTP1B), T‐cell protein tyrosine phosphatase (TCPTP), and Src homology phosphatase 2 (SHP2) are established regulators of insulin signaling in vivo and implicated in renal
Grace LeBleu, Ming‐Fo Hsu, Yoshihiro Ito, Suh‐Yuen Liang, Kwan‐Liu Ma, Tzu‐Ching Meng, Fawaz G. Haj   +6 more
wiley   +1 more source

Nephrin Deficiency Activates NF-κB and Promotes Glomerular Injury [PDF]

Journal of the American Society of Nephrology, 2009
Increasing evidence implicates activation of NF-kappaB in a variety of glomerular diseases, but the mechanisms involved are unknown. Here, upregulation of NF-kappaB in the podocytes of transgenic mice resulted in glomerulosclerosis and proteinuria.
Hussain, S, Romio, L, Saleem, MA, Mathieson, PW, Serrano, M, Moscat, J, Diaz-Meco, M, Scambler, P, Koziell, A   +8 more
openaire   +4 more sources

Mutational analysis of the PLCE1 gene in steroid-resistant nephrotic syndrome [PDF]

, 2010
International audienceBackground: Mutations in the PLCE1 gene encoding phospholipase C epsilon 1 (PLCε1) have been recently described in patients with early-onset nephrotic syndrome (NS) and diffuse mesangial sclerosis (DMS).
Audrey Pawtowski, Audrey Pawtowski, Chantal Loirat, Constantinos J, Corinne Antignac, Et Al. Mu, Fabien Nevo, Fabien Nevo, Georges Deschênes, Hal Id Inserm, Ilmay Bilge, Kenza Soulami, Lisa M. Guay, Marie-alice Macher, Marie-claire Gubler, Michelle Hall, Olivia Boyer, Olivia Boyer, Olivier Gribouval, Olivier Gribouval, Robert Weiss, Zelal Bircan   +21 more
core   +7 more sources

A Rare NPHS2 Mutation (E130K) in Hereditary Steroid‐Resistant Nephrotic Syndrome: A Case Report

Case Reports in Nephrology, Volume 2026, Issue 1, 2026.
Hereditary steroid‐resistant nephrotic syndrome (HSRNS) due to mutations in the NPHS2 gene (encoding podocin) is a rare genetic condition that typically presents in childhood. We report a case of a 2‐year‐and‐8‐month‐old male, the seventh child of consanguineous parents, who presented with recurrent fever, febrile tonic‐clonic seizures, and periorbital
Ramzi Hmedan Mujahed, Omar Hammam Salloum, Nimatallah Fares Ishreiteh, Hiba Mofdi Hosheyh, Aisha Dahood Abu Hashem, Yara Fadi Shamestti, Malak Ramzy Hroub, Poorani Gurumallesh Prabu   +7 more
wiley   +1 more source

Expression of human nephrin mRNA in diabetic nephropathy [PDF]

Nephrology Dialysis Transplantation, 2004
Diabetic nephropathy (DN) is associated with functional changes in the filtration barrier, and microalbuminuria is a strong predictor of the development of overt DN. Nephrin is a novel podocyte-specific protein which localizes at the slit diaphragm.
Masao, Toyoda, Daisuke, Suzuki, Tomoya, Umezono, Goro, Uehara, Mayumi, Maruyama, Masashi, Honma, Takako, Sakai, Hideto, Sakai   +7 more
openaire   +2 more sources

Genetic testing for nephrotic syndrome and FSGS in the era of next-generation sequencing [PDF]

, 2014
The haploid human genome is composed of three billion base pairs, about one percent of which consists of exonic regions, the coding sequence for functional proteins, also now known as the “exome”.
Barua, Moumita, Brown, Elizabeth J., Pollak, Martin R.   +2 more
core   +1 more source