Results 81 to 90 of about 12,065 (211)
Nephrin Promotes Cell-Cell Adhesion through Homophilic Interactions [PDF]
The American Journal of Pathology, 2003 Nephrin is a type-1 transmembrane protein and a key component of the podocyte slit diaphragm, the ultimate glomerular plasma filter. Genetic and acquired diseases affecting expression or function of nephrin lead to severe proteinuria and distortion or absence of the slit diaphragm.
Jamshid, Khoshnoodi +6 more
openaire +2 more sources
Acta Physiologica, Volume 242, Issue 3, March 2026.ABSTRACT Aim The glomerulus is a specialized microvascular unit that filters plasma through the coordinated function of podocytes and parietal epithelial cells (PECs). From this perspective, the glomerulus functions like a living hydrogeological filtration system.
Maria Elena Melica +3 more
wiley +1 more source
Renal Implications of Psoriasis: Urinary Podocyte Markers and Disease Progression
Dermatology Practical & ConceptualIntroduction: Psoriasis may lead to glomerular inflammatory damage and disruption of the podocyte barrier, allowing podocyte degradation products to leak into the urine.
Sule Gencoglu +2 more
doaj +1 more source
PLoS ONE, 2009 Glomerular visceral epithelial cells (podocytes) contain interdigitated processes that form specialized intercellular junctions, termed slit diaphragms, which provide a selective filtration barrier in the renal glomerulus.
Tomonori Hirose +9 more
doaj +1 more source
Diverse Levels of Sequence Selectivity and Catalytic Efficiency of Protein-Tyrosine Phosphatases [PDF]
, 2014 The sequence selectivity of 14 classical protein-tyrosine phosphatases (PTPs) (PTPRA, PTPRB, PTPRC, PTPRD, PTPRO, PTP1B, SHP-1, SHP-2, HePTP, PTP-PEST, TCPTP, PTPH1, PTPD1, and PTPD2) was systematically profiled by screening their catalytic domains ...
Bell, Charles E. +7 more
core +1 more source
Nephrin Deficiency Activates NF-κB and Promotes Glomerular Injury [PDF]
Journal of the American Society of Nephrology, 2009 Increasing evidence implicates activation of NF-kappaB in a variety of glomerular diseases, but the mechanisms involved are unknown. Here, upregulation of NF-kappaB in the podocytes of transgenic mice resulted in glomerulosclerosis and proteinuria.
Hussain, S +8 more
openaire +4 more sources
Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle +6 more
wiley +1 more source
Expression of human nephrin mRNA in diabetic nephropathy [PDF]
Nephrology Dialysis Transplantation, 2004 Diabetic nephropathy (DN) is associated with functional changes in the filtration barrier, and microalbuminuria is a strong predictor of the development of overt DN. Nephrin is a novel podocyte-specific protein which localizes at the slit diaphragm.
Masao, Toyoda +7 more
openaire +2 more sources
Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS
Advanced Science, Volume 13, Issue 10, 18 February 2026.This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu +14 more
wiley +1 more source
Genetic testing for nephrotic syndrome and FSGS in the era of next-generation sequencing [PDF]
, 2014 The haploid human genome is composed of three billion base pairs, about one percent of which consists of exonic regions, the coding sequence for functional proteins, also now known as the “exome”.
Barua, Moumita +2 more
core +1 more source