Results 91 to 100 of about 4,454 (194)

Sialic acid acquisition in bacteria - one substrate many transporters [PDF]

, 2016
The sialic acids are a family of 9-carbon sugar acids found predominantly on the cell-surface glycans of humans and other animals within the Deuterostomes and are also used in the biology of a wide range of bacteria that often live in association with ...
Thomas, Gavin Hugh
core   +1 more source

Development of a protocol for maintaining viability while shipping organoid-derived retinal tissue. [PDF]

, 2020
Retinal organoid technology enables generation of an inexhaustible supply of three-dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications.
Binette, Francois, Glickman, Randolph D, Nasonkin, Igor O, Petersen-Jones, Simon M, Seiler, Magdalene, Singh, Ratnesh K, Winkler, Paige   +6 more
core   +1 more source

Revolutionizing Heart Valve Therapy: A Translational Framework for Combining Decellularized Scaffolds With Genetic Modification

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 11, November 2025.
ABSTRACT Valvular heart disease (VHD) represents a significant global health challenge, affecting over 2.5% of the population and disproportionately impacting older adults due to age‐related degenerative processes. Current treatment options—mechanical and bioprosthetic valves—both present substantial limitations that impact patient quality of life and ...
Nikolaos P. Tzavellas, Natalia Atzemoglou, Efstathios L. Pavlidis, Alkinoos Nikolis, Georgios S. Markopoulos, Konstantinos I. Tsamis, Dimitrios Peschos, Yannis V. Simos, Lampros Lakkas   +8 more
wiley   +1 more source

Reduced binding of human antibodies to cells from GGTA1/CMAH KO pigs [PDF]

, 2014
Xenotransplantation using genetically modified pig organs could solve the donor organ shortage problem. Two inactivated genes that make humans unique from pigs are GGTA1 and CMAH, the products of which produce the carbohydrate epitopes, aGal and Neu5Gc ...
Burlak, C., Estrada, J., Li, P., Lutz, A. J., Paris, L. L., Sidner, R. A., Tector, A. J., Tector, M.   +7 more
core   +1 more source

Deadly Lifeworlds Meet Palliative Politics: Struggle in Circulation

Antipode, Volume 57, Issue 6, Page 2326-2348, November 2025.
Abstract This paper locates acute and ongoing crises of coloniality and ecology within struggles over circulation that are anchored in infrastructure. If infrastructure organises movement—including its constraint in carceral forms—then it is also a linchpin for materialising distinct regimes of motion (Nail 2020a; Marx in Motion: A New Materialist ...
Deborah Cowen
wiley   +1 more source

A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study presents a comprehensive data mining strategy for in‐depth extraction of overall and altered glycan features from structural and site‐specific glycoproteome data across various biomedical samples. The strategy enables the uncovery of four major altered glycan features associated with thymic involution and reveals their coordinated ...
Zhida Zhang, Yongqi Wu, Ke Hou, Yiwen Zhang, Lin Chen, Muyao Yang, Zhehui Jin, Yongchao Xu, Yingjie Zhang, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
wiley   +1 more source

A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation [PDF]

, 2016
Glycosylation greatly influences the safety and efficacy of many of the highest-selling recombinant therapeutic proteins (rTPs). In order to define optimal cell culture feeding strategies that control rTP glycosylation, it is necessary to know how ...
Jimenez del Val, I, Kontoravdi, C, Polizzi, K   +2 more
core   +1 more source

Molecular characterization of cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) gene and frequency of blood types in stray cats of İzmir, Turkey

BMC Genomics, 2021
Background Cytidine monophospho-n-acetylneuraminic acid hydroxylase (CMAH) gene associated with blood groups in cats encodes CMAH enzyme that converts Neu5Ac to Neu5Gc.
Hüseyin Can, Sedef Erkunt Alak, Ahmet Efe Köseoğlu, Umut Şahar, Berna Bostanbaş, Serdar Baydarlı, Mert Döşkaya, Cemal Ün   +7 more
doaj   +1 more source

Siglec receptors impact mammalian lifespan by modulating oxidative stress. [PDF]

, 2015
Aging is a multifactorial process that includes the lifelong accumulation of molecular damage, leading to age-related frailty, disability and disease, and eventually death. In this study, we report evidence of a significant correlation between the number
Fu, Xiaoming, Gagneux, Pascal, Garcia, Javier O, Garcia-Bingman, Andrea, Glass, Christopher K, Hazen, Stanley L, Heyser, Charles, Lin, Hongqiao, Läubli, Heinz, Pearce, Oliver MT, Romanoski, Casey E, Samraj, Annie N, Schwarz, Flavio, Secrest, Patrick, Varki, Ajit, Varki, Nissi, Wang, Xiaoxia   +16 more
core   +1 more source

Exploring Siglecs: Potential Modulators of Immune Cells in Food Allergy and Therapeutic Applications

Clinical &Experimental Allergy, Volume 55, Issue 10, Page 889-900, October 2025.
Sialic acid‐binding immunoglobulin‐type lectins (Siglecs) are inhibitory receptors present on all immune cells involved in the allergic reaction. Currently, research is mostly focussed on targeting Siglecs on mast cells to possibly treat food allergies.
J. S. H. Schaapherder, K. C. M. Verhoeckx, A. M. Ehlers, E. F. Knol, A. C. Knulst, L. A. P. M. Meulenbroek   +5 more
wiley   +1 more source