Results 81 to 90 of about 3,321 (184)

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, Volume 9, Issue 6, Page 1142-1166, June 2026.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Method establishment for discerned immunogenicity assessment of a recombinant glycoprotein containing nonhuman sialic acid Neu5Gc residues

, 2017
Aim: Recombinant glycoprotein produced in nonhuman mammalian cell lines can be modified with the immunogenic nonhuman sialic N-glycolylneuraminic acid (Neu5Gc).
Heinrich Faust, Marc-Olivier Montjovent, Linglong Zou, Petra Struwe, Afsaneh Abdolzade-Bavil, Patrick M Liu   +5 more
core   +1 more source

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, Volume 3, Issue 2, Page 87-101, June 2026.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu, Ben Huang, Lingyan Wang, Qiang Guo, Cuiping Jiang, Ruicheng Qi, Shuyao Wang, Lin‐Tai Da, Wenjie Peng   +8 more
wiley   +1 more source

Xenogeneic Neu5Gc and self-glycan Neu5Ac epitopes are potential immune targets in MS. [PDF]

, 2020
OBJECTIVE To explore the repertoire of glycan-specific immunoglobulin G (IgG) antibodies in treatment-naive patients with relapsing-remitting multiple sclerosis (RRMS). METHODS A systems-level approach combined with glycan array technologies was
Keller, Christian W, Oechtering, Johanna, Peschke, Benjamin, Bovin, Nicolai, Kuhle, Jens, Cummings, Richard D, Rieben, Robert, von Gunten, Stephan, Boligan, Kayluz F., Kappos, Ludwig, Lünemann, Jan D   +10 more
core   +2 more sources

Mucin Type Drives Composition and Mucin Glycan Degradation of an In Vitro Synthetic Microbial Community

Environmental Microbiology, Volume 28, Issue 5, May 2026.
The human gut outer mucus layer hosts specific microbes. Using a synthetic mucin glycan‐degrading microbial community to mimic this mucosal microbiome, we show that mucin type affects microbial community composition, glycan degradation and metabolite production.
Maryse D. Berkhout, Carol de Ram, Merlijn P. van Gaal, Henk Schols, Clara Belzer, Caroline M. Plugge   +5 more
wiley   +1 more source

Affinity purified Chicken IgY antibody recognizes Neu5Gc with various linkages to underlying glycans.

, 2013
A. Detection of Neu5Gc on synthetic and semi-synthetic molecules. Reactivity of the affinity-purified anti-Neu5Gc antibody was tested in triplicate, by ELISA against synthetic and semi-synthetic Neu5Gc- and Neu5Ac-target pairs, using Neu5Ac-glycans for ...
Nancy Hurtado-Ziola (375365), Els C. M. Brinkman-Van der Linden (375366), Hai Yu (366836), Sandra L. Diaz (375362), Vered Padler-Karavani (375363), Nissi M. Varki (243827), Ajit Varki (375367), Darius Ghaderi (375364), Xi Chen (35903)   +8 more
core   +1 more source

Early Experimental Report of the First 8‐Gene‐Edited Pig‐to‐Rhesus Macaque Cardiac Xenotransplantation in China

Xenotransplantation, Volume 33, Issue 3, May/June 2026.
ABSTRACT Objectives This study aimed to investigate the functional recovery of an 8‐gene‐edited pig heart after orthotopic xenotransplantation, the characteristics of the recipient's immune responses, and the efficacy of postoperative complication management to provide comprehensive experimental evidence for the clinical translation of xenogeneic ...
Xianzhi Wang, Xijie Wu, Ziqiang Dai, Licheng Yan, Jie Yan, Dongsheng He, Shangxuan Li, Zhipeng Ren, Gen Zhang, Guanzheng Cui, Xin Li, Xianhua Li, Yulong Guan, Guangyu Pan, Ik Jin Yun, Wensheng Zhou, Dengke Pan, Dianyuan Li   +17 more
wiley   +1 more source

Human Natural Antibodies to Mammalian Carbohydrate Antigens as Unsung Heroes Protecting against Past, Present, and Future Viral Infections

Antibodies, 2020
Human natural antibodies to mammalian carbohydrate antigens (MCA) bind to carbohydrate-antigens synthesized in other mammalian species and protect against zoonotic virus infections.
Uri Galili
doaj   +1 more source

Enhancing Lipidomics With High‐Resolution Ion Mobility‐Mass Spectrometry

PROTEOMICS, Volume 26, Issue 4, Page 7-22, April 2026.
ABSTRACT Lipids, indispensable yet structurally intricate biomolecules, serve as critical regulators of cellular function and disease progression. Conventional lipidomics, constrained by limited resolution for isomeric and low‐abundance species, has been transformed by ion mobility‐mass spectrometry (IM‐MS).
Gaoyuan Lu, Shuling Xu, Penghsuan Huang, Lingjun Li   +3 more
wiley   +1 more source