Results 61 to 70 of about 3,321 (184)

Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. [PDF]

PLoS Pathogens, 2018
While infectious agents have typical host preferences, the noninvasive enteric bacterium Vibrio cholerae is remarkable for its ability to survive in many environments, yet cause diarrheal disease (cholera) only in humans. One key V.
Frederico Alisson-Silva, Janet Z Liu, Sandra L Diaz, Lingquan Deng, Mélanie G Gareau, Ronald Marchelletta, Xi Chen, Victor Nizet, Nissi Varki, Kim E Barrett, Ajit Varki   +10 more
doaj   +1 more source

Untersuchung von Anti‐Glykan‐Antikörpern und Erforschung ihres medizinischen Potenzials mithilfe synthetischer Glykane

Angewandte Chemie, EarlyView.
Anti‐Glykan‐Antikörper spielen sowohl bei Gesundheit als auch bei Krankheit eine wesentliche Rolle. Der Zugang zu neuartigen Glykanstrukturen ermöglicht Fortschritte bei der Antikörpercharakterisierung für die Entdeckung von Biomarkern, die Antikörperentwicklung und das Impfstoffdesign.
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N-Acetylneuraminic Acid as a Host Adaptation

mBio, 2019
Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative bacterial pathogen that is adapted exclusively to human hosts. NTHi utilizes sialic acid from the host as a carbon source and as a terminal sugar on the outer membrane glycolipid ...
Preston S. K. Ng, Christopher J. Day, John M. Atack, Lauren E. Hartley-Tassell, Linda E. Winter, Tal Marshanski, Vered Padler-Karavani, Ajit Varki, Stephen J. Barenkamp, Michael A. Apicella, Michael P. Jennings   +10 more
doaj   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Xenotransplantation of the Porcine Lung—From Immunological Barriers to Emerging Experimental Strategies

Xenotransplantation, Volume 33, Issue 5, September/October 2026.
ABSTRACT Lung transplantation is the only long‐lasting life‐saving treatment for patients with end‐stage pulmonary disease, but the ever‐growing shortage of suitable donor organs leads to high mortality rates of the afflicted patients. Xenotransplantation, the transplantation of organs across species, has emerged as a promising alternative. This review
Nathalie Roters, Niveditha Varma, Robert Ramm, Heiner Niemann, Patrick Zardo, Arjang Ruhparwar, Tobias Goecke   +6 more
wiley   +1 more source

Maternal and infant gut microbiome

iMeta, Volume 5, Issue 4, August 2026.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source

Presentation Mode of Glycans Affect Recognition of Human Serum anti-Neu5Gc IgG Antibodies [PDF]

, 2019
Recognition of carbohydrates by antibodies can be affected by antigen composition and density. This had been investigated in a variety of controllable multivalent systems using synthetic carbohydrate antigens, yet such effects on anticarbohydrate ...
Reuven, Eliran Moshe, Chen, Xi, Galinanes, Manuel, Cristina Costa, Arye, Shani Leviatan Ben, Hai Yu, Vered Padler-Karavani, Xi Chen, Manuel Galiñanes, Ben Arye, Shani Leviatan, Costa Vallés, Cristina, Eliran Moshe Reuven, Yu, Hai, Salam Bashir, Shani Leviatan Ben Arye, Bashir, Salam, Bottio, Tomaso, Costa, Cristina, Tomaso Bottio, Leviatan Ben Arye, Shani, Padler-Karavani, Vered   +20 more
core   +1 more source

Reduced Complement and Granulocyte Activation by α‐Gal Knockout Porcine Pericardium for Bioprosthetic Heart Valves: A Pilot Hemocompatibility Study

Journal of Biomedical Materials Research Part A, Volume 114, Issue 7, July 2026.
Genetically modified, α‐Gal‐depleted porcine pericardium and wild type tissues are investigated for hemocompatibility and material properties such as mechanobiology and ECM profile to carve out the suitability of the gene‐modified tissue as material for biological heart valve prostheses. ABSTRACT Xenogeneic pericardium is the main source for biological
Claudia Dittfeld, Elisabeth Kemter, Barbara Kessler, Eckhard Wolf, Anett Jannasch, Claudia Sperling, Sems‐Malte Tugtekin, Manfred F. Maitz   +7 more
wiley   +1 more source

Electrochemical Evaluation of Tumor Development via Cellular Interface Supported CRISPR/Cas Trans-Cleavage

Research, 2022
Evaluating tumor development is of great importance for clinic treatment and therapy. It has been known that the amounts of sialic acids on tumor cell membrane surface are closely associated with the degree of cancerization of the cell. So, in this work,
Liangfen Cheng, Fuhan Yang, Longfei Tang, Lelin Qian, Xu Chen, Feng Guan, Juan Zhang, Genxi Li   +7 more
doaj   +1 more source