Results 51 to 60 of about 3,321 (184)

Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products.

PLoS ONE, 2009
BackgroundHumans are genetically defective in synthesizing the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc), but can metabolically incorporate it from dietary sources (particularly red meat and milk) into glycoproteins and glycolipids ...
Sandra L Diaz, Vered Padler-Karavani, Darius Ghaderi, Nancy Hurtado-Ziola, Hai Yu, Xi Chen, Els C M Brinkman-Van der Linden, Ajit Varki, Nissi M Varki   +8 more
doaj   +1 more source

Antitumor effects of the GM3(Neu5Gc) ganglioside-specific humanized antibody 14F7hT against Cmah-transfected cancer cells. [PDF]

, 2019
The GM3(Neu5Gc) ganglioside represents a tumor-specific antigen that is considered a promising target for cancer immunotherapy. We previously demonstrated that the humanized antibody 14F7hT, specific for this ganglioside, exhibited significant antitumor ...
Simon, Hans-Uwe, López-Requena, Alejandro, Mesa, Circe, Frias Boligan, Kayluz, Labrada, Mayrel, Relova-Hernández, Ernesto, Clavell, Marilyn, Dorvignit, Denise, von Gunten, Stephan, López, Armando   +9 more
core   +2 more sources

Comparison of sialic acid content in bovine and buffalo milk and meat

Revista Científica, 2023
Animal-origin food, such as meat and milk, are important sources of sialic acids (SIAs) with relevant implications for human health. Two significant SIAs in mammals are N-acetyl-neuraminic acid (Neu5Ac) and N- glycolylneuraminic acid (Neu-5Gc).
Michela Contò, Simona Rinaldi, Sebastiana Failla   +2 more
doaj   +1 more source

The Structural Complexity and Animal Tissue Distribution of N-Glycolylneuraminic Acid (Neu5Gc)-Terminated Glycans. Implications for Their Immunogenicity in Clinical Xenografting

Frontiers in Molecular Biosciences, 2019
N-Glycolylneuraminic acid (Neu5Gc)-terminated glycans are present in all animal cells/tissues that are already used in the clinic such as bioprosthetic heart valves (BHV) as well as in those that potentially will be xenografted in the future to overcome ...
Michael E. Breimer, Jan Holgersson
doaj   +1 more source

N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease

BMC Cancer, 2022
Background Normal human tissues do not express glycans terminating with the sialic acid N-glycolylneuraminic acid (Neu5Gc), yet Neu5Gc-containing glycans have been consistently found in human tumor tissues, cells and secretions and have been proposed as ...
Lucy K. Shewell, Christopher J. Day, Jamie R. Kutasovic, Jodie L. Abrahams, Jing Wang, Jessica Poole, Colleen Niland, Kaltin Ferguson, Jodi M. Saunus, Sunil R. Lakhani, Mark von Itzstein, James C. Paton, Adrienne W. Paton, Michael P. Jennings   +13 more
doaj   +1 more source

Molecular Structural Analysis of Porcine CMAH–Native Ligand Complex and High Throughput Virtual Screening to Identify Novel Inhibitors

Pathogens, 2023
Porcine meat is the most consumed red meat worldwide. Pigs are also vital tools in biological and medical research. However, xenoreactivity between porcine’s N-glycolylneuraminic acid (Neu5Gc) and human anti-Neu5Gc antibodies poses a significant ...
Oluwamayowa Joshua Ogun, Georg Thaller, Doreen Becker   +2 more
doaj   +1 more source

Involvement of a Non-Human Sialic Acid in Human Cancer

Frontiers in Oncology, 2014
Sialic acids are common monosaccharides that are widely expressed as outer terminal units on all vertebrate cell surfaces, and play fundamental roles in cell-cell and cell-microenvironment interactions.
Annie eSamraj, Heinz eLäubli, Nissi eVarki, Ajit eVarki   +3 more
doaj   +1 more source

Challenging the Role of Diet-Induced Anti-Neu5Gc Antibodies in Human Pathologies [PDF]

Frontiers in Immunology, 2020
No abstract ...
Soulillou, Jean-Paul, Cozzi, Emanuele, Bach, Jean-Marie   +2 more
openaire   +5 more sources

Carbohydrates great and small, from dietary fiber to sialic acids: How glycans influence the gut microbiome and affect human health

Gut Microbes, 2021
Gut microbiome composition depends heavily upon diet and has strong ties to human health. Dietary carbohydrates shape the gut microbiome by providing a potent nutrient source for particular microbes.
Joanna K Coker, Oriane Moyne, Dmitry A. Rodionov, Karsten Zengler   +3 more
doaj   +1 more source

N-glycolyl chondroitin synthesis using metabolically engineered E. coli

AMB Express, 2020
N-glycolyl chondroitin (Gc-CN) is a metabolite of N -glycolylneuraminic acid (Neu5Gc), a sialic acid that is commonly found in mammals, but not humans. Humans can incorporate exogenous Neu5Gc into their tissues from eating red meat.
Adeola E. Awofiranye, Sultan N. Baytas, Ke Xia, Abinaya Badri, Wenqin He, Ajit Varki, Mattheos Koffas, Robert J. Linhardt   +7 more
doaj   +1 more source