Results 41 to 50 of about 3,321 (184)

Detection of Neu5Gc Tumour Antigens

, 2023
Aberrant glycosylation is a common feature of all human cancer cells and plays roles in tumour progression by modulating tumour proliferation, invasion and metastasis.
Wang, Jing
core   +1 more source

Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism [PDF]

BioMed Research International, 2014
Background. N-Glycolylneuraminic acid (Neu5Gc) is a sialic acid synthesized by animals, but not by humans or birds. However, it can be incorporated in human cells and can trigger immune response. In the present study, we detected anti-Neu5Gc antibodies in samples of the general population and of patients suffering from hypothyroidism/Hashimoto’s ...
Phaedra Eleftheriou, Stavros Kynigopoulos, Alexandra Giovou, Alexandra Mazmanidi, John Yovos, Petros Skepastianos, Eleni Vagdatli, Christos Petrou, Dafni Papara, Maria Efterpiou   +9 more
openaire   +2 more sources

Differential Recognition of Diet-Derived Neu5Gc-Neoantigens on Glycan Microarrays by Carbohydrate-Specific Pooled Human IgG and IgA Antibodies [PDF]

, 2019
Sialic acids (Sias) cover vertebrate cell surface glycans. N-Acetylneuraminic acid (Neu5Ac) and its hydroxylated form N-glycolylneuraminic acid (Neu5Gc) are common Sia in mammals.
Chen, Xi, Christoph Schneider, Vered Padler-Karavani (375363), Hai Yu, Vered Padler-Karavani, Schneider, Christoph, Xi Chen, Stephan von Gunten, Xi Chen (35903), Leviatan Ben-Arye, Shani, Yu, Hai, Salam Bashir, Shani Leviatan Ben-Arye, Bashir, Salam, Hai Yu (366836), Stephan von Gunten (340797), Shani Leviatan Ben-Arye (6440699), Ben-Arye, Shani Leviatan, Christoph Schneider (413360), Salam Bashir (6631076), von Gunten, Stephan, Padler-Karavani, Vered   +21 more
core   +3 more sources

Absorption and Transport Mechanism of Red Meat-Derived N-glycolylneuraminic Acid and Its Damage to Intestinal Barrier Function through the NF-κB Signaling Pathway

Toxins, 2023
N-glycolylneuraminic acid (Neu5Gc) is a specific factor in red meat that induces intestinal disease. Our aim was to investigate the effect of Neu5Gc on the intestinal barrier as well as its mechanism of endocytosis and exocytosis. Ten specific inhibitors
Enqi He, Wei Quan, Jie Luo, Chuxin Liu, Wanting Zheng, Qingwu Shen   +5 more
doaj   +1 more source

An Overview of the Importance and Value of Porcine Species in Sialic Acid Research

Biology, 2022
Humans frequently interact with pigs, whose meat is also one of the primary sources of animal protein. They are one of the main species at the center of sialic acid (Sia) research.
Oluwamayowa Joshua Ogun, Georg Thaller, Doreen Becker   +2 more
doaj   +1 more source

Reply to Mackenzie: A comparison of Neu5Gc and α-gal xenoantigens [PDF]

Proceedings of the National Academy of Sciences, 2015
We appreciate the thoughtful comments of K. J. Mackenzie (1) regarding our findings, concerning how a red meat-derived glycan can promote inflammation and cancer progression (2). At first glance, there do indeed appear to be very close similarities between the nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc) antigen we are describing and the ...
Oliver M T, Pearce, Annie N, Samraj, Heinz, Läubli, Nissi M, Varki, Ajit, Varki   +4 more
openaire   +2 more sources

Dietary Neu5Ac Intervention Protects Against Atherosclerosis Associated with Human-Like Neu5Gc loss [PDF]

, 2021
OBJECTIVE: Species-specific pseudogenization of the CMAH gene during human evolution eliminated common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) biosynthesis from its precursor, N-acetylneuraminic acid (Neu5Ac).
Gordts, Philip LSM, Zengler, Karsten, Kawanishi, Kunio, Coker, Joanna K, Grunddal, Kaare V., Varki, Ajit, Hsiao, Jason, Gordts, Philip L.S.M., Grunddal, Kaare V, Varki, Nissi, Dhar, Chirag   +10 more
core   +1 more source

Glycosylated Biotherapeutics: Immunological Effects of N-Glycolylneuraminic Acid

Frontiers in Immunology, 2020
The emerging field of biotherapeutics provides successful treatments for various diseases, yet immunogenicity and limited efficacy remain major concerns for many products.
Sharon Yehuda, Vered Padler-Karavani
doaj   +1 more source

N-Glycolylneuraminic Acid in Animal Models for Human Influenza A Virus

Viruses, 2021
The first step in influenza virus infection is the binding of hemagglutinin to sialic acid-containing glycans present on the cell surface. Over 50 different sialic acid modifications are known, of which N-acetylneuraminic acid (Neu5Ac) and N ...
Cindy M. Spruit, Nikoloz Nemanichvili, Masatoshi Okamatsu, Hiromu Takematsu, Geert-Jan Boons, Robert P. de Vries   +5 more
doaj   +1 more source

Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk.

PLoS ONE, 2018
BackgroundN-glycolylneuraminic acid (Neu5Gc) is a non-human red-meat-derived sialic acid immunogenic to humans. Neu5Gc can be metabolically incorporated into glycan chains on human endothelial and epithelial surfaces. This represents the first example of
Annie N Samraj, Kimberly A Bertrand, Robert Luben, Zahra Khedri, Hai Yu, Dzung Nguyen, Christopher J Gregg, Sandra L Diaz, Sherilyn Sawyer, Xi Chen, Heather Eliassen, Vered Padler-Karavani, Kana Wu, Kay-Tee Khaw, Walter Willett, Ajit Varki   +15 more
doaj   +1 more source