Results 21 to 30 of about 2,530 (163)

Effect of Pulsed Electric Field Treatment on N-Hydroxyacetylneuraminic Acid Content and Eating Quality of Pork [PDF]

Shipin Kexue, 2023
This study investigated how to reduce the content of N-hydroxyacetylneuraminic acid (Neu5Gc) in pork. By using Neu5Gc standard solution, porcine submandibular gland mucin (PSM) solution, meat pieces and minced meat as experimental subjects, and high ...
LIU Chuxin, LOU Aihua, WU Yanyang, HE Enqi, ZHENG Wanting, HE Rongxin, SHEN Qingwu
doaj   +1 more source

Synthesis of α‐(2→5)Neu5Gc Oligomers. [PDF]

ChemInform, 2003
AbstractA facile synthesis of the sialic acid oligomers α‐(2→5)Neu5Gc (1) is presented. Monosaccharides 2–4 with suitable functionality were used as the building blocks. After selective removal of the paired carboxyl and amine protecting groups, the fully protected oligomers were assembled through consecutive coupling of the building blocks by well ...
Chien-Tai, Ren, Chien-Sheng, Chen, Yi-Ping, Yu, Yow-Fu, Tsai, Ping-Yu, Lin, Yu-Ju, Chen, Wei, Zou, Shih-Hsiung, Wu   +7 more
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At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody [PDF]

Scientific Reports, 2016
AbstractTwo non-human glycan epitopes, galactose-α-1,3-galactose (α-gal) and Neu5Gc-α-2-6-galactose (Neu5Gc) have been shown to be antigenic when attached to Fab oligosaccharides of monoclonal antibodies (mAbs) , while α-gal attached to Fc glycans was not.
Yu, C, Gao, K, Zhu, L, Wang, W, Wang, L, Zhang, F, Liu, C, Li, M, Wormald, M, Rudd, P, Wang, J   +10 more
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Erratum: At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody [PDF]

Scientific Reports, 2017
Scientific Reports 6: Article number: 20029; published online: 29 January 2016; updated: 30 June 2017. The original HTML version of this Article listed an incorrect volume number. This has now been corrected in the HTML version; the PDF version was correct at the time of publication.
Yu, Chuanfei, Gao, Kai, Zhu, Lei, Wang, Wenbo, Wang, Lan, Zhang, Feng, Liu, Chunyu, Li, Meng, Wormald, Mark R., Rudd, Pauline M., Wang, Junzhi   +10 more
openaire   +2 more sources

Association between Neu5Gc carbohydrate and serum antibodies against it provides the molecular link to cancer: French NutriNet-Santé study

BMC Medicine, 2020
Background High consumption of red and processed meat is commonly associated with increased cancer risk, particularly colorectal cancer. Antibodies against the red meat-derived carbohydrate N-glycolylneuraminic acid (Neu5Gc) exacerbate cancer in “human ...
Salam Bashir, Leopold K. Fezeu, Shani Leviatan Ben-Arye, Sharon Yehuda, Eliran Moshe Reuven, Fabien Szabo de Edelenyi, Imen Fellah-Hebia, Thierry Le Tourneau, Berthe Marie Imbert-Marcille, Emmanuel B. Drouet, Mathilde Touvier, Jean-Christian Roussel, Hai Yu, Xi Chen, Serge Hercberg, Emanuele Cozzi, Jean-Paul Soulillou, Pilar Galan, Vered Padler-Karavani   +18 more
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Aberrant N-glycolylneuraminic acid in breast MCF-7 cancer cells and cancer stem cells

Frontiers in Molecular Biosciences, 2022
N-Glycolylneuraminic acid (Neu5Gc) is not normally detected in humans because humans lack the hydroxylase enzyme that converts cytidine-5′-monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac) to CMP-Neu5Gc; thus, any Neu5Gc appearing in the human body is ...
Wenqian Yang, Yuan Jiang, Qulian Guo, Zhixin Tian, Zhigang Cheng   +4 more
doaj   +1 more source

Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism [PDF]

BioMed Research International, 2014
Background. N-Glycolylneuraminic acid (Neu5Gc) is a sialic acid synthesized by animals, but not by humans or birds. However, it can be incorporated in human cells and can trigger immune response. In the present study, we detected anti-Neu5Gc antibodies in samples of the general population and of patients suffering from hypothyroidism/Hashimoto’s ...
Phaedra Eleftheriou, Stavros Kynigopoulos, Alexandra Giovou, Alexandra Mazmanidi, John Yovos, Petros Skepastianos, Eleni Vagdatli, Christos Petrou, Dafni Papara, Maria Efterpiou   +9 more
openaire   +2 more sources

A simple method for assessment of human anti-Neu5Gc antibodies applied to Kawasaki disease. [PDF]

PLoS ONE, 2013
N-glycolylneuraminic acid (Neu5Gc) is an immunogenic sugar of dietary origin that metabolically incorporates into diverse native glycoconjugates in humans.
Vered Padler-Karavani, Adriana H Tremoulet, Hai Yu, Xi Chen, Jane C Burns, Ajit Varki   +5 more
doaj   +1 more source

Absorption and Transport Mechanism of Red Meat-Derived N-glycolylneuraminic Acid and Its Damage to Intestinal Barrier Function through the NF-κB Signaling Pathway

Toxins, 2023
N-glycolylneuraminic acid (Neu5Gc) is a specific factor in red meat that induces intestinal disease. Our aim was to investigate the effect of Neu5Gc on the intestinal barrier as well as its mechanism of endocytosis and exocytosis. Ten specific inhibitors
Enqi He, Wei Quan, Jie Luo, Chuxin Liu, Wanting Zheng, Qingwu Shen   +5 more
doaj   +1 more source

Reply to Mackenzie: A comparison of Neu5Gc and α-gal xenoantigens [PDF]

Proceedings of the National Academy of Sciences, 2015
We appreciate the thoughtful comments of K. J. Mackenzie (1) regarding our findings, concerning how a red meat-derived glycan can promote inflammation and cancer progression (2). At first glance, there do indeed appear to be very close similarities between the nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc) antigen we are describing and the ...
Oliver M T, Pearce, Annie N, Samraj, Heinz, Läubli, Nissi M, Varki, Ajit, Varki   +4 more
openaire   +2 more sources