Results 11 to 20 of about 3,321 (184)

Structure aided design of a Neu5Gc specific lectin [PDF]

Scientific Reports, 2017
Subtilase cytotoxin (SubAB) of Escherichia coli is an AB5 class bacterial toxin. The pentameric B subunit (SubB) binds the cellular carbohydrate receptor, α2–3-linked N-glycolylneuraminic acid (Neu5Gc).
Christopher J. Day, Adrienne W. Paton, Melanie A. Higgins, Lucy K. Shewell, Freda E.-C. Jen, Benjamin L. Schulz, Brock P. Herdman, James C. Paton, Michael P. Jennings   +8 more
doaj   +7 more sources

Characterization of an Aptamer Targeting Neu5Gc, as an Endogenous Pathogenic Factor Derived from Red Meat

Molecules
N-glycolylneuraminic acid (Neu5Gc), a sialic acid predominantly found in the non-neurohumoral fluids of hind-mouthed animals, is incapable of synthesizing Neu5Gc due to a deletion in the CMAH exon of the gene encoding human CMP-Neu5Gc hydroxylase.
Yansong Li, Pan Hu
exaly   +4 more sources

Characterization of immunogenic Neu5Gc in bioprosthetic heart valves [PDF]

Xenotransplantation, 2018
Background: The two common sialic acids (Sias) in mammals are N-acetylneuraminic acid (Neu5Ac) and its hydroxylated form N-glycolylneuraminic acid (Neu5Gc). Unlike most mammals, humans cannot synthesize Neu5Gc that is considered foreign and recognized by
Cozzi, Emanuele, Chen, Xi, Fellah-Hebia, Imen, Galinanes, Manuel, Moshe Reuven, Eliran, Marshanski, Tal, Máñez Mendiluce, Rafael, Costa Vallés, Cristina, Leviatan Ben-Arye, Shani, Yu, Hai, Roussel, Jean-Christian, Soulillou, Jean-Paul, Breimer, Michael E., Tourneau, Thierry Le, Padler-Karavani, Vered   +14 more
core   +11 more sources

At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody [PDF]

Scientific Reports, 2016
Two non-human glycan epitopes, galactose-Į-1,3-galactose (Į-gal) and Neu5Gc-Į-2-6-galactose (Neu5Gc) have been shown to be antigenic when attached to Fab oligosaccharides of monoclonal antibodies (mAbs) , while Į-gal attached to Fc glycans were not ...
Yu, Chuanfei, Zhu, Lei, Wang, Wenbo, Wang, Lan, Li, M, Wormald, Mark, Rudd, Pauline M., Li, Meng, Rudd, PM, Wang, Junzhi, Liu, Chunyu, Yu, C, Gao, K, Zhu, L, Wang, J, Zhang, F, Wang, L, Wormald, MR, Liu, C, Wenbo, W, Gao, Kai, Zhang, Feng   +21 more
core   +5 more sources

Chimeric antigen receptor T cells targeting the GM3(Neu5Gc) ganglioside

Frontiers in Immunology
Chimeric antigen receptor (CAR) T cell technology has ushered in a new era of immunotherapy, enabling the targeting of a broad range of surface antigens, surpassing the limitations of traditional T cell epitopes.
Ute Krengel, Geir Åge Løset, Ludvig A Munthe   +2 more
exaly   +5 more sources

The Poor Performance of Neu5Gc for Endometrial Receptivity in Embryo Transfer

Journal of Bio-X Research
Neu5Gc is a common sialic acid in mammals, but humans cannot synthesize it independently. When Neu5Gc in the diet enters the body, the body produces antibodies against Neu5Gc, which in turn promotes the immune response and chronic inflammation and may be
Yunfeng Lin, Qicai Liu
doaj   +3 more sources

Potential deleterious role of anti-Neu5Gc antibodies in xenotransplantation

Xenotransplantation, 2014
International audienceHuman beings do not synthesize the glycolyl form of the sialic acid (Neu5Gc) and only express the acetylated form of the sugar, whereas a diet-based intake of Neu5Gc provokes a natural immunization and production of anti-Neu5Gc ...
Evanno, Gwénaëlle, Jean-Paul Soulillou, Jean Harb, Gwénaëlle Evanno, Salama, Apolline, Apolline Salama, Harb, Jean, Soulillou, Jean-Paul   +7 more
core   +5 more sources

A simple method for assessment of human anti-Neu5Gc antibodies applied to Kawasaki disease. [PDF]

PLoS ONE, 2013
N-glycolylneuraminic acid (Neu5Gc) is an immunogenic sugar of dietary origin that metabolically incorporates into diverse native glycoconjugates in humans.
Vered Padler-Karavani, Adriana H Tremoulet, Hai Yu, Xi Chen, Jane C Burns, Ajit Varki   +5 more
doaj   +3 more sources

Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans. [PDF]

PLoS ONE, 2017
Our group previously investigated the levels of anti-Gal and anti-nonGal IgM and IgG in a cohort of 75 healthy humans of various backgrounds, and found some significant differences related to factors such as age, gender, ABO blood group, diet ...
Bingsi Gao, Cassandra Long, Whayoung Lee, Zhongqiang Zhang, Xiaotian Gao, Doug Landsittel, Mohamed Ezzelarab, David Ayares, Yuliang Huang, David K C Cooper, Yi Wang, Hidetaka Hara   +11 more
doaj   +4 more sources

Wild and domestic animals variably display Neu5Ac and Neu5Gc sialic acids [PDF]

Glycobiology, 2022
Sialic acids are used as a receptor by several viruses and variations in the linkage type or C-5 modifications affect the binding properties. A species barrier for multiple viruses is present due to α2,3- or α2,6-linked sialic acids.
Rijks, Jolianne M, Nemanichvili, Nikoloz, Spruit, Cindy M, Gröne, Andrea, de Vries, Robert P, Verheije, Monique H, Berends, Alinda J   +6 more
core   +6 more sources