Results 11 to 20 of about 2,530 (163)
Chimeric antigen receptor T cells targeting the GM3(Neu5Gc) ganglioside
Frontiers in ImmunologyChimeric antigen receptor (CAR) T cell technology has ushered in a new era of immunotherapy, enabling the targeting of a broad range of surface antigens, surpassing the limitations of traditional T cell epitopes.
Marte Fauskanger +2 more
exaly +5 more sources
Structure aided design of a Neu5Gc specific lectin
Scientific Reports, 2017 Subtilase cytotoxin (SubAB) of Escherichia coli is an AB5 class bacterial toxin. The pentameric B subunit (SubB) binds the cellular carbohydrate receptor, α2–3-linked N-glycolylneuraminic acid (Neu5Gc).
Christopher J. Day +8 more
doaj +6 more sources
Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans. [PDF]
PLoS ONE, 2017 Our group previously investigated the levels of anti-Gal and anti-nonGal IgM and IgG in a cohort of 75 healthy humans of various backgrounds, and found some significant differences related to factors such as age, gender, ABO blood group, diet ...
Bingsi Gao +11 more
doaj +4 more sources
MoleculesN-glycolylneuraminic acid (Neu5Gc), a sialic acid predominantly found in the non-neurohumoral fluids of hind-mouthed animals, is incapable of synthesizing Neu5Gc due to a deletion in the CMAH exon of the gene encoding human CMP-Neu5Gc hydroxylase.
Yansong Li, Pan Hu, Li Yansong
exaly +3 more sources
Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution [PDF]
Inflammation and RegenerationDuring human evolution, some genes were lost or silenced from the genome of hominins. These missing genes might be the key to the evolution of humans’ unique cognitive skills. An inactivation mutation in CMP-N-acetylneuraminic acid hydroxylase (CMAH) was
Yuxin Liu, Jinhong Li, Qicai Liu
doaj +2 more sources
Variability of Sialic Acids in Beef Breeds and Nutritional Implications in Red Meat [PDF]
MoleculesThis study examines the variability of sialic acids, specifically N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), in beef from seven cattle breeds (Holstein Friesian, Red Pied, Maremmana, Chianina, Charolais, Limousin, and ...
Michela Contò +3 more
doaj +2 more sources
The Poor Performance of Neu5Gc for Endometrial Receptivity in Embryo Transfer
Journal of Bio-X ResearchNeu5Gc is a common sialic acid in mammals, but humans cannot synthesize it independently. When Neu5Gc in the diet enters the body, the body produces antibodies against Neu5Gc, which in turn promotes the immune response and chronic inflammation and may be
Yunfeng Lin, Qicai Liu
doaj +2 more sources
Detection of N-glycolyl-neuraminic acid-containing glycolipids in human skin
Frontiers in Immunology, 2023 Humans lack the enzyme that produces the sialic acid N-glycolyl neuraminic acid (Neu5Gc), but several lines of evidence have shown that Neu5Gc can be taken up by mammalian food sources and replace the common human sialic acid N-acetyl neuraminic acid ...
Michela Manni +10 more
doaj +1 more source
Preferential Accumulation of 14C-N-Glycolylneuraminic Acid over 14C-N-Acetylneuraminic Acid in the Rat Brain after Tail Vein Injection. [PDF]
PLoS ONE, 2015 The two main molecular species of sialic acid existing in nature are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). Neu5Ac is abundant in mammalian brains and plays crucial roles in many neural functions.
Risa Taguchi +6 more
doaj +1 more source
N-glycolylneuraminic acid as a carbohydrate cancer biomarker
Translational Oncology, 2023 One of the forms of aberrant glycosylation in human tumors is the expression of N-glycolylneuraminic acid (Neu5Gc). The only known enzyme to biosynthesize Neu5Gc in mammals, cytidine-5′-monophosphate-N-acetylneuraminic acid (CMAH), appears to be ...
Jing Wang +3 more
doaj +1 more source