Anti-Neu5Gc Antibody Kit Protocol - Flow Cytometry v2
, 2017 Anti-Neu5Gc may be used for staining cells prior to analysis by Flow Cytometry. This kit contains all the essential components needed to identify Neu5Gc on the surface of cells by flow cytometry.
Kelsey Miller
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Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay [PDF]
Journal of Visualized Experiments, 2017 Cells are covered with a cloak of carbohydrate chains (glycans) that is commonly altered in cancer and that includes variations in sialic acid (Sia) expression. These are acidic sugars that have a 9-carbon backbone and that cap vertebrate glycans on cell
Chen, Xi +7 more
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Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution
Inflammation and RegenerationDuring human evolution, some genes were lost or silenced from the genome of hominins. These missing genes might be the key to the evolution of humans’ unique cognitive skills. An inactivation mutation in CMP-N-acetylneuraminic acid hydroxylase (CMAH) was
Yuxin Liu, Jinhong Li, Qicai Liu
doaj +3 more sources
Detection of N-glycolyl-neuraminic acid-containing glycolipids in human skin
Frontiers in Immunology, 2023 Humans lack the enzyme that produces the sialic acid N-glycolyl neuraminic acid (Neu5Gc), but several lines of evidence have shown that Neu5Gc can be taken up by mammalian food sources and replace the common human sialic acid N-acetyl neuraminic acid ...
Michela Manni +10 more
doaj +1 more source
N-glycolylneuraminic acid as a carbohydrate cancer biomarker
Translational Oncology, 2023 One of the forms of aberrant glycosylation in human tumors is the expression of N-glycolylneuraminic acid (Neu5Gc). The only known enzyme to biosynthesize Neu5Gc in mammals, cytidine-5′-monophosphate-N-acetylneuraminic acid (CMAH), appears to be ...
Jing Wang +3 more
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Preferential Accumulation of 14C-N-Glycolylneuraminic Acid over 14C-N-Acetylneuraminic Acid in the Rat Brain after Tail Vein Injection. [PDF]
PLoS ONE, 2015 The two main molecular species of sialic acid existing in nature are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). Neu5Ac is abundant in mammalian brains and plays crucial roles in many neural functions.
Risa Taguchi +6 more
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Effect of Pulsed Electric Field Treatment on N-Hydroxyacetylneuraminic Acid Content and Eating Quality of Pork [PDF]
Shipin Kexue, 2023 This study investigated how to reduce the content of N-hydroxyacetylneuraminic acid (Neu5Gc) in pork. By using Neu5Gc standard solution, porcine submandibular gland mucin (PSM) solution, meat pieces and minced meat as experimental subjects, and high ...
LIU Chuxin, LOU Aihua, WU Yanyang, HE Enqi, ZHENG Wanting, HE Rongxin, SHEN Qingwu
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Synthesis of α‐(2→5)Neu5Gc Oligomers. [PDF]
ChemInform, 2003 AbstractA facile synthesis of the sialic acid oligomers α‐(2→5)Neu5Gc (1) is presented. Monosaccharides 2–4 with suitable functionality were used as the building blocks. After selective removal of the paired carboxyl and amine protecting groups, the fully protected oligomers were assembled through consecutive coupling of the building blocks by well ...
Chien-Tai, Ren +7 more
openaire +2 more sources
Erratum: At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody [PDF]
Scientific Reports, 2017 Scientific Reports 6: Article number: 20029; published online: 29 January 2016; updated: 30 June 2017. The original HTML version of this Article listed an incorrect volume number. This has now been corrected in the HTML version; the PDF version was correct at the time of publication.
Yu, Chuanfei +10 more
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Aberrant N-glycolylneuraminic acid in breast MCF-7 cancer cells and cancer stem cells
Frontiers in Molecular Biosciences, 2022 N-Glycolylneuraminic acid (Neu5Gc) is not normally detected in humans because humans lack the hydroxylase enzyme that converts cytidine-5′-monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac) to CMP-Neu5Gc; thus, any Neu5Gc appearing in the human body is ...
Wenqian Yang +4 more
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