Results 11 to 20 of about 4,454 (194)
Structure aided design of a Neu5Gc specific lectin
Scientific Reports, 2017 Subtilase cytotoxin (SubAB) of Escherichia coli is an AB5 class bacterial toxin. The pentameric B subunit (SubB) binds the cellular carbohydrate receptor, α2–3-linked N-glycolylneuraminic acid (Neu5Gc).
Christopher J. Day +8 more
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Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans. [PDF]
PLoS ONE, 2017 Our group previously investigated the levels of anti-Gal and anti-nonGal IgM and IgG in a cohort of 75 healthy humans of various backgrounds, and found some significant differences related to factors such as age, gender, ABO blood group, diet ...
Bingsi Gao +11 more
doaj +4 more sources
N-Glycolylneuraminic Acid (Neu5Gc) Null Large Animals by Targeting the CMP-Neu5Gc Hydroxylase (CMAH) [PDF]
Frontiers in Immunology, 2019 The two major sialic acids described in mammalian cells are the N-glycolylneuraminic acid (Neu5Gc) and the N-acetylneuraminic acid (Neu5Ac). Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group ...
Andrea Perota +2 more
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The Possible Role of Anti-Neu5Gc as an Obstacle in Xenotransplantation [PDF]
Frontiers in Immunology, 2020 Seventy to ninety percentage of preformed xenoreactive antibodies in human serum bind to the galactose-α(1,3)-galactose Gal epitope, and the creation of Gal knockout (KO) pigs has eliminated hyperacute rejection as a barrier to xenotransplantation.
Alfred Joseph Tector +3 more
doaj +5 more sources
Chimeric antigen receptor T cells targeting the GM3(Neu5Gc) ganglioside
Frontiers in ImmunologyChimeric antigen receptor (CAR) T cell technology has ushered in a new era of immunotherapy, enabling the targeting of a broad range of surface antigens, surpassing the limitations of traditional T cell epitopes.
Julia Heinzelbecker +9 more
doaj +3 more sources
Antibody-Targeted Artificial T Cell and Natural Killer Cell Derived Vesicles for Cancer Immunotherapy. [PDF]
J Extracell VesiclesABSTRACT T cell and NK92 cell‐derived extracellular vesicles or artificial cell‐derived vesicles (ACDVs) exhibit anti‐cancer effects through inherited cytotoxic proteins like perforin and granzyme or transmembrane receptors like FasL and TRAIL. The anti‐cancer potential of artificial T and NK vesicles has been improved by attaching targeting moieties ...
Parlekar B +7 more
europepmc +2 more sources
Effect of Pulsed Electric Field Treatment on N-Hydroxyacetylneuraminic Acid Content and Eating Quality of Pork [PDF]
Shipin Kexue, 2023 This study investigated how to reduce the content of N-hydroxyacetylneuraminic acid (Neu5Gc) in pork. By using Neu5Gc standard solution, porcine submandibular gland mucin (PSM) solution, meat pieces and minced meat as experimental subjects, and high ...
LIU Chuxin, LOU Aihua, WU Yanyang, HE Enqi, ZHENG Wanting, HE Rongxin, SHEN Qingwu
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Synthesis of α‐(2→5)Neu5Gc Oligomers. [PDF]
ChemInform, 2003 AbstractA facile synthesis of the sialic acid oligomers α‐(2→5)Neu5Gc (1) is presented. Monosaccharides 2–4 with suitable functionality were used as the building blocks. After selective removal of the paired carboxyl and amine protecting groups, the fully protected oligomers were assembled through consecutive coupling of the building blocks by well ...
Chien-Tai, Ren +7 more
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At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody [PDF]
Scientific Reports, 2016 AbstractTwo non-human glycan epitopes, galactose-α-1,3-galactose (α-gal) and Neu5Gc-α-2-6-galactose (Neu5Gc) have been shown to be antigenic when attached to Fab oligosaccharides of monoclonal antibodies (mAbs) , while α-gal attached to Fc glycans was not.
Yu, C +10 more
openaire +3 more sources
BMC Medicine, 2020 Background High consumption of red and processed meat is commonly associated with increased cancer risk, particularly colorectal cancer. Antibodies against the red meat-derived carbohydrate N-glycolylneuraminic acid (Neu5Gc) exacerbate cancer in “human ...
Salam Bashir +18 more
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