Results 21 to 30 of about 4,454 (194)
Erratum: At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody [PDF]
Scientific Reports, 2017 Scientific Reports 6: Article number: 20029; published online: 29 January 2016; updated: 30 June 2017. The original HTML version of this Article listed an incorrect volume number. This has now been corrected in the HTML version; the PDF version was correct at the time of publication.
Yu, Chuanfei +10 more
openaire +2 more sources
Aberrant N-glycolylneuraminic acid in breast MCF-7 cancer cells and cancer stem cells
Frontiers in Molecular Biosciences, 2022 N-Glycolylneuraminic acid (Neu5Gc) is not normally detected in humans because humans lack the hydroxylase enzyme that converts cytidine-5′-monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac) to CMP-Neu5Gc; thus, any Neu5Gc appearing in the human body is ...
Wenqian Yang +4 more
doaj +1 more source
Characterization of immunogenic Neu5Gc in bioprosthetic heart valves [PDF]
Xenotransplantation, 2016 AbstractBackgroundThe two common sialic acids (Sias) in mammals are N‐acetylneuraminic acid (Neu5Ac) and its hydroxylated form N‐glycolylneuraminic acid (Neu5Gc). Unlike most mammals, humans cannot synthesize Neu5Gc that is considered foreign and recognized by circulating antibodies.
Reuven, Eliran +14 more
openaire +7 more sources
A simple method for assessment of human anti-Neu5Gc antibodies applied to Kawasaki disease. [PDF]
PLoS ONE, 2013 N-glycolylneuraminic acid (Neu5Gc) is an immunogenic sugar of dietary origin that metabolically incorporates into diverse native glycoconjugates in humans.
Vered Padler-Karavani +5 more
doaj +1 more source
Overdose intake of Neu5Gc triggers colorectal inflammation and alters liver metabolism
Food and Agricultural Immunology, 2023 A positive correlation between massive red meat consumption with colorectal cancer had been reported. Given the complexity of meat components, we focused on investigating the role of Neu5Gc in human healthy.
Teng Yuan +11 more
doaj +1 more source
Serum Neu5Gc biomarkers are elevated in primary cutaneous melanoma
Biochemical and Biophysical Research Communications, 2023 Cutaneous melanoma is one of the most aggressive and deadly types of skin cancer and rates of disease are continuing to increase worldwide. Currently, no serum biomarkers exist for the early detection of cutaneous melanoma. Normal human cells cannot make the sialic acid sugar, Neu5Gc, yet human tumor cells express Neu5Gc and Neu5Gc-containing ...
Lucy K. Shewell +6 more
openaire +3 more sources
The First Clinical Renal Xenotransplantation Study (EXPAND): Evaluating Safety, Function, and Zoonotic Risks. [PDF]
Health Care SciHealth Care Science, Volume 4, Issue 6, Page 377-380, December 2025.
Nashan B.
europepmc +2 more sources
Toxins, 2023 N-glycolylneuraminic acid (Neu5Gc) is a specific factor in red meat that induces intestinal disease. Our aim was to investigate the effect of Neu5Gc on the intestinal barrier as well as its mechanism of endocytosis and exocytosis. Ten specific inhibitors
Enqi He +5 more
doaj +1 more source
The use of transgenic animals for xenotransplantation: An update. [PDF]
Animal Model Exp MedOne way to produce genetically modified pigs is to use somatic cell nuclear transfer (SCNT). This procedure involves removing the metaphase plate from a mature oocyte using micromanipulation and then transferring the modified nucleus from the donor somatic cell to the oocyte.
Motławska J +3 more
europepmc +2 more sources
Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism [PDF]
BioMed Research International, 2014 Background. N-Glycolylneuraminic acid (Neu5Gc) is a sialic acid synthesized by animals, but not by humans or birds. However, it can be incorporated in human cells and can trigger immune response. In the present study, we detected anti-Neu5Gc antibodies in samples of the general population and of patients suffering from hypothyroidism/Hashimoto’s ...
Phaedra Eleftheriou +9 more
openaire +2 more sources