Results 1 to 10 of about 7,575 (155)

Memantine, Simvastatin, and Epicatechin Inhibit 7-Ketocholesterol-induced Apoptosis in Retinal Pigment Epithelial Cells But Not Neurosensory Retinal Cells In Vitro [PDF]

Journal of Ophthalmic & Vision Research, 2020
Purpose: 7-ketocholesterol (7kCh), a natural byproduct of oxidation in lipoprotein deposits is implicated in the pathogenesis of diabetic retinopathy and age-related macular degeneration (AMD).
Aneesh Neekhra, Julia Tran, Parsa R. Esfahani, Kevin Schneider, Khoa Pham, Ashish Sharma, Marilyn Chwa, Saurabh Luthra, Ana L. Gramajo, Saffar Mansoor, Baruch D. Kuppermann, M. Cristina Kenney   +11 more
doaj   +7 more sources

Effect of bevacizumab (Avastin TM ) on mitochondrial function of in vitro retinal pigment epithelial, neurosensory retinal and microvascular endothelial cells

Indian Journal of Ophthalmology, 2013
Purpose: To evaluate the effect of bevacizumab on the mitochondrial function of human retinal pigment epithelial (ARPE-19), rat neurosensory retinal (R28) and human microvascular endothelial (HMVEC) cells in culture.
Saurabh Luthra, Ashish Sharma, Joyce Dong, Aneesh Neekhra, Ana L Gramajo, Gail M Seigel, M Cristina Kenney, Baruch D Kuppermann   +7 more
doaj   +5 more sources

On the Wrong Track: Alterations of Ciliary Transport in Inherited Retinal Dystrophies

Frontiers in Cell and Developmental Biology, 2021
Ciliopathies are a group of heterogeneous inherited disorders associated with dysfunction of the cilium, a ubiquitous microtubule-based organelle involved in a broad range of cellular functions. Most ciliopathies are syndromic, since several organs whose
Laura Sánchez-Bellver, Laura Sánchez-Bellver, Vasileios Toulis, Vasileios Toulis, Gemma Marfany, Gemma Marfany, Gemma Marfany   +6 more
doaj   +1 more source

Differential distribution of steroid hormone signaling networks in the human choroid-retinal pigment epithelial complex

BMC Ophthalmology, 2022
Background The retinal pigment epithelium (RPE), a layer of pigmented cells that lies between the neurosensory retina and the underlying choroid, plays a critical role in maintaining the functional integrity of photoreceptor cells and in mediating ...
Sydney M. Galindez, Andrew Keightley, Peter Koulen   +2 more
doaj   +1 more source

Vision and retina evolution: How to develop a retina

IBRO Neuroscience Reports, 2022
Early in vertebrate evolution, a single homeobox (Hox) cluster in basal chordates was quadrupled to generate the Hox gene clusters present in extant vertebrates.
Bernd Fritzsch, Paul R. Martin
doaj   +1 more source

Resolution of Combined Hamartoma of Retina And Retinal Pigment Epithelium (CHRRPE) with Following Pars Plana Vitrectomy

Delhi Journal of Ophthalmology, 2021
Combined hamartoma of retina and retinal pigment epithelium (CHRRPE) is a benign tumor located at the posterior pole. The pathogenesis of the lesion is unknown however some authors propose that the tumor may arise from undifferentiated ectopic progenitor
Monika Kapoor, Siddharth Madan, Priyanka Sankaran, Preeti Singh, Sarita Beri   +4 more
doaj   +1 more source

Comparison of CRISPR/Cas Endonucleases for in vivo Retinal Gene Editing

Frontiers in Cellular Neuroscience, 2020
CRISPR/Cas has opened the prospect of direct gene correction therapy for some inherited retinal diseases. Previous work has demonstrated the utility of adeno-associated virus (AAV) mediated delivery to retinal cells in vivo; however, with the expanding ...
Fan Li, Fan Li, Kristof Wing, Jiang-Hui Wang, Chi D. Luu, Chi D. Luu, James A. Bender, Jinying Chen, Jinying Chen, Qi Wang, Qinyi Lu, Minh Thuan Nguyen Tran, Kaylene M. Young, Raymond C. B. Wong, Raymond C. B. Wong, Alice Pébay, Alice Pébay, Anthony L. Cook, Sandy S. C. Hung, Sandy S. C. Hung, Guei-Sheung Liu, Guei-Sheung Liu, Alex W. Hewitt, Alex W. Hewitt   +23 more
doaj   +1 more source

Preoperative electrophysiological characterization of patients with primary macula-involving rhegmatogenous retinal detachment [PDF]

, 2018
Purpose: To determine 1) which components of retinal function are impaired after rhegmatogenous retinal detachment, 2) which outer retinal pathways (rod- or cone-driven) are more severely affected, and 3) whether there is concomitant inner retinal ...
Apte, Rajendra, Lin, Jonathan, Sein, Julia, Van Stavern, Gregory   +3 more
core   +3 more sources

Trypan Blue: Effect on Retinal Pigment Epithelial and Neurosensory Retinal Cells

Investigative Opthalmology & Visual Science, 2005
To evaluate the toxicity of trypan blue on retinal cells in vitro.Human retinal pigment epithelial cells (ARPE-19) and rat neurosensory retinal cells (R28) were grown in tissue culture and treated with four different concentrations of trypan blue (0.1%, 0.05%, 0.025%, and 0.0125%), in combination with surgical light exposure (0, 5, or 10 minutes). Cell
Raja, Narayanan, M Cristina, Kenney, Sami, Kamjoo, Thuan-Hau T, Trinh, Gail M, Seigel, Gilberto P, Resende, Baruch D, Kuppermann   +6 more
openaire   +2 more sources

Correlation from undiluted vitreous cytokines of untreated central retinal vein occlusion with spectral domain optical coherence tomography [PDF]

, 2013
Purpose: To correlate inflammatory and proangiogenic key cytokines from undiluted vitreous of treatment-naïve central retinal vein occlusion (CRVO) patients with SD-OCT parameters. Methods: Thirty-five patients (age 71.1 years, 24 phakic, 30 nonischemic)
Cinatl, Jindrich, Koch, Frank H., Kohnen, Thomas, Koss, Michael Janusz, Pfister, Marcel, Rejdak, Robert, Ribeiro, Ramiro M., Rothweiler, Florian, Schubert, Ralf   +8 more
core   +1 more source