Results 211 to 220 of about 195,340 (251)
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Molecular mechanisms in neurotransmitter release
Current Opinion in Neurobiology, 1991The vesicle hypothesis of neurotransmitter release was first formulated in the 1950s, but only recently have the molecular mechanisms involved in neurotransmitter release begun to be elucidated. This short review summarizes current concepts on neurosecretion and the available information on synaptic vesicle exocytosis.
M. Matteoli, P. De Camilli
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UNC-13 and neurotransmitter release
Nature Neuroscience, 1999Genetic studies in mice, worms and flies indicate that the synaptic protein UNC-13 plays a central role in the regulation of vesicle fusion.
H, Tokumaru, G J, Augustine
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In Vitro Reconstitution of Neurotransmitter Release
Neurochemical Research, 1998The vesicular hypothesis has stimulated fruitful investigations on many secreting systems. In the case of rapid synaptic transmission, however, the hypothesis has been found difficult to reconcile with a number of well established observations. Brief impulses of transmitter molecules (quanta) are emitted from nerve terminals at the arrival of an action
Dunant Y, Israël M
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Molecular mechanisms of neurotransmitter release
Muscle & Nerve, 2001AbstractThe release of neurotransmitter from neurons represents one of the pivotal events in synaptic transmission. Neurotransmitters are released from synaptic vesicles in presynaptic neurons in response to neural activity, diffuse across the synaptic cleft, and bind specific receptors in order to bring about changes in postsynaptic neurons.
E A, Fon, R H, Edwards
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Regulation of the Release of Coexisting Neurotransmitters
Annual Review of Pharmacology and Toxicology, 1988The joy of neurobiologists at the discovery of the coexistence of several neuroactive substances within the same neuron terminals can be compared with the delight of a man who has bought a radio he thought would only receive AM broadcasts, but who then discovers that it also gets all the FM stations.
T, Bartfai +3 more
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1999
Abstract Understanding the mechanisms that underlie brain activity and function remains one of the major frontiers of biology. All the processes of how we co-ordinate our movements, sense our surroundings, react to stimuli and learn and retain information rely on complicated networks of neurons that communicate with each other and their ...
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Abstract Understanding the mechanisms that underlie brain activity and function remains one of the major frontiers of biology. All the processes of how we co-ordinate our movements, sense our surroundings, react to stimuli and learn and retain information rely on complicated networks of neurons that communicate with each other and their ...
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Airway nerves: neurotransmitter release
Current Opinion in Pharmacology, 2002A number of methods exist that allow one to study the pharmacology of neuropeptide release in the airways. Methods include in vitro organ bath techniques to measure neuropeptide release functionally as changes in smooth-muscle tone and direct measurement of neuropeptide release from airway tissue or cultured sensory neurones. The measurement of sensory
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Calcium Sensors of Neurotransmitter Release
2023Calcium (Ca2+) plays a critical role in triggering all three primary modes of neurotransmitter release (synchronous, asynchronous, and spontaneous). Synaptotagmin1, a protein with two C2 domains, is the first isoform of the synaptotagmin family that was identified and demonstrated as the primary Ca2+ sensor for synchronous neurotransmitter release ...
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Release of neurotransmitters in the locus coeruleus
Progress in Neurobiology, 1998In the past 15 years the release of neurotransmitters and their metabolites in the locus coeruleus (LC) has been studied by using three approaches: microdialysis; push-pull superfusion; and voltammetry. These sophisticated techniques, which render it possible to follow the time course and magnitude of neurochemical changes in anaesthetized and ...
N, Singewald, A, Philippu
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2017
The biochemical and physiological processes of neurotransmitter release from an active zone, a specialized region of synaptic membrane, are examined. Synaptic vesicles containing neurotransmitters are docked at the active zone and then primed for release by SNARE complexes that bring them into extreme proximity to the plasma membrane.
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The biochemical and physiological processes of neurotransmitter release from an active zone, a specialized region of synaptic membrane, are examined. Synaptic vesicles containing neurotransmitters are docked at the active zone and then primed for release by SNARE complexes that bring them into extreme proximity to the plasma membrane.
openaire +1 more source