Results 11 to 20 of about 7,064 (199)

Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos [PDF]

Disease Models & Mechanisms, 2018
Human mutations in the planar cell polarity component VANGL2 are associated with the neural tube defect spina bifida. Homozygous Vangl2 mutation in mice prevents initiation of neural tube closure, precluding analysis of its subsequent roles in ...
Gabriel L. Galea, Oleksandr Nychyk, Matteo A. Mole, Dale Moulding, Dawn Savery, Evanthia Nikolopoulou, Deborah J. Henderson, Nicholas D. E. Greene, Andrew J. Copp   +8 more
doaj   +7 more sources

Planar polarization of endogenous ADIP during Xenopus neurulation. [PDF]

Biol Open
This dataset contains raw fluorescence microscopy images and corresponding image quantification files supporting the study “Planar polarization of endogenous ADIP during Xenopus neurulation,” published in Biology Open. Raw data consist of original images
Santhi Velayudhan S, Itoh K, Chu CW, Alfandari D, Sokol SY.   +4 more
europepmc   +2 more sources

Vangl2–environment interaction causes severe neural tube defects, without abnormal neuroepithelial convergent extension

Disease Models & Mechanisms, 2022
Planar cell polarity (PCP) signalling is vital for initiation of mouse neurulation, with diminished convergent extension (CE) cell movements leading to craniorachischisis, a severe neural tube defect (NTD).
Oleksandr Nychyk, Gabriel L. Galea, Matteo Molè, Dawn Savery, Nicholas D. E. Greene, Philip Stanier, Andrew J. Copp   +6 more
doaj   +1 more source

Exome Sequencing in Prenatally Diagnosed Isolated Neural Tube Defects: A Subtype-Specific Analysis. [PDF]

Prenat Diagn
ABSTRACT Objective To explore potential genetic contributors across different subtypes of isolated neural tube defects (NTDs) ‐ acrania–exencephaly–anencephaly sequence (AEAS), spinal dysraphism, and encephalocele ‐ using exome sequencing (ES) in a prenatal cohort, with the goal of gaining insight into the molecular diversity underlying these distinct ...
Botvinik A, Glasner VO, Reches A, Miremberg H, Haratz KK, Brill T, Malki L, Rozenzwaig M, Yaron Y, Levy M.   +9 more
europepmc   +2 more sources

Overview of Secondary Neurulation [PDF]

Journal of Korean Neurosurgical Society, 2021
Secondary neurulation is a morphological process described since the second half of the 19th century; it accounts for the formation of the caudal spinal cord in mammals including humans. A similar process takes place in birds. This form of neurulation is caused by the growth of the tail bud region, the most caudal axial region of the embryo ...
openaire   +2 more sources

Case series of cranial and spinal dysraphism

National Journal of Clinical Anatomy, 2022
Neural tube defects (NTDs) are the second most common cause of congenital anomaly worldwide (cardiac anomalies is the first). The 3rd and 4th week of gestation is the critical period for neural tube development. Multiple genetic and environmental factors
Gayathri Pandurangam, D Nagajyothi, Seethamsetty Saritha, Asra Anjum   +3 more
doaj   +1 more source

Morphological phenotyping after mouse whole embryo culture

Frontiers in Cell and Developmental Biology, 2023
Morphological phenotyping of the mouse embryo is described at neurulation stages, primarily as a guide to evaluating the outcome of whole embryo cultures between embryonic days 8.5 and 9.5.
Andrew J. Copp, Maryam Clark, Nicholas D. E. Greene   +2 more
doaj   +1 more source

Neural Differentiation of Induced Pluripotent Stem Cells for a Xenogeneic Material-Free 3D Neurological Disease Model Neurulation from Pluripotent Cells Using a Human Hydrogel

Current Issues in Molecular Biology, 2023
Alzheimer’s Disease (AD) is characterized by synapse and neuronal loss and the accumulation of neurofibrillary tangles and Amyloid β plaques. Despite significant research efforts to understand the late stages of the disease, its etiology remains largely ...
Luis Sebastian Alexis Valerio, Frederick Robert Carrick, Lina Bedoya, Sandeep Sreerama, Kiminobu Sugaya   +4 more
doaj   +1 more source

Role of YAP in early ectodermal specification and a Huntington's Disease model of human neurulation

eLife, 2022
The Hippo pathway, a highly conserved signaling cascade that functions as an integrator of molecular signals and biophysical states, ultimately impinges upon the transcription coactivator Yes-associated protein 1 (YAP). Hippo-YAP signaling has been shown
Francesco M Piccolo, Nathaniel R Kastan, Tomomi Haremaki, Qingyun Tian, Tiago L Laundos, Riccardo De Santis, Andrew J Beaudoin, Thomas S Carroll, Ji-Dung Luo, Ksenia Gnedeva, Fred Etoc, AJ Hudspeth, Ali H Brivanlou   +12 more
doaj   +1 more source

Hallmarks of primary neurulation are conserved in the zebrafish forebrain

Communications Biology, 2021
Jonathan Werner, Maraki Negesse et al. visualize zebrafish neurulation during development to determine whether hallmarks of neural tube formation in other vertebrates also apply to zebrafish.
Jonathan M. Werner, Maraki Y. Negesse, Dominique L. Brooks, Allyson R. Caldwell, Jafira M. Johnson, Rachel M. Brewster   +5 more
doaj   +1 more source