Results 41 to 50 of about 12,090 (225)

Neogenin and RGMa control neural tube closure and neuroepithelial morphology by regulating cell polarity [PDF]

, 2008
In humans, neural tube closure defects occur in 1: 1000 pregnancies. The design of new strategies for the prevention of such common defects would benefit from an improved understanding of the molecular events underlying neurulation. Neural fold elevation
Bradford, DanaKai, Cooper, Helen M., De Vries, Melissa, Kee, Nigel, Key, Brian, Wilson, Nicole   +5 more
core   +1 more source

NEONATAL DYSFUNCTIONS RESPONSIBLE (EVENTUALLY) FOR DEFINITIVE NEUROLOGICAL HANDICAPS [PDF]

Romanian Journal of Pediatrics, 2009
Beside several malformations, especially cerebral (neurulation disorders, agenesia of the corpus callosum, neuronal migration disorders, etc.), the main neonatal causes of neurological sequelar handicaps are: hipoxya, intracerebral hemorrhage, nuclear ...
Andrei Zamfirescu
doaj   +1 more source

Molecular Characterization of the Gastrula in the Turtle Emys orbicularis: An Evolutionary Perspective on Gastrulation [PDF]

, 2008
Due to the presence of a blastopore as in amphibians, the turtle has been suggested to exemplify a transition form from an amphibian- to an avian-type gastrulation pattern.
A Perea-Gomez, A Simeone, AJ Levine, Arnaud Menuet, Aurélie Gombault, C Viebahn, CD Stern, CD Stern, CL Peichel, CL Yntema, Claude Pieau, D Acampora, D Arendt, Daphne Soares, Delphine Nicolle, DG Wilkinson, E Gilland, EM del Pino, G Guyot, H Ibrahim, H Meinhardt, H Meinhardt, IM Moya, J Pasteels, JA Gauthier, JC Smith, JD Barnes, Jean-Louis Plouhinec, JH Fritzenwanker, JL Plouhinec, L Bally-Cuif, M Chandrasekharan Nayar, M Coolen, M Dorizzi, M Pannese, M Rhinn, M Rhinn, M Taira, M Taira, Marion Coolen, Mitsukuri, MW Nachman, O Voiculescu, PW Holland, R Keller, R Vignali, S Schulte-Merker, SC Chapman, Sylvie Mazan, T Sauka-Spengler, Tatjana Sauka-Spengler, V Knezevic, W Shawlot, Y Kraus   +53 more
core   +11 more sources

Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell–cell junctions during neural tube formation

Developmental Dynamics, EarlyView.
Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Derrick Thomas, Brittany M. Hufft‐Martinez, Zarna Lalwani, Vi Pham, Mary Elmeniawi, An J. Tran, Jianming Xu, Irfan Saadi, Walid D. Fakhouri   +8 more
wiley   +1 more source

Distinct modes of floor plate induction in the chick embryo [PDF]

, 2003
To begin to reconcile models of floor plate formation in the vertebrate neural tube, we have performed experiments aimed at understanding the development of the early floor plate in the chick embryo. Using real-time analyses of cell behaviour, we provide
Fraser, Scott, Kulesa, Paul, Patten, Iain, Placzek, Maryisa, Shen, Michael M.   +4 more
core   +1 more source

Imaging spectrum of spinal dysraphism: A diagnostic challenge

South African Journal of Radiology, 2023
Spinal dysraphism (SD) is a collective term for congenital malformations of the spine and spinal cord. It includes a wide range of congenital anomalies resulting from aberrations in the stages of gastrulation, primary neurulation and secondary ...
Mohit K. Shrivastva, Mousam Panigrahi
doaj   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Neural tube defects: recent advances, unsolved questions, and controversies [PDF]

, 2013
Neural tube defects are severe congenital malformations affecting around one in every 1000 pregnancies. An innovation in clinical management has come from the finding that closure of open spina bifida lesions in utero can diminish neurological ...
Copp, AJ, Greene, NDE, Stanier, P
core   +1 more source

Standardization of egg activation and fertilization in sterlet (Acipenser ruthenus)

Aquaculture Reports, 2020
This study was conducted to determine the minimum number of spermatozoa and optimal volume of activation water for effective fertilization of sterlet Acipenser ruthenus eggs.
Otomar Linhart, Yu Cheng, Miaomiao Xin, Marek Rodina, Vladimíra Tučková, William L. Shelton, Vojtěch Kašpar   +6 more
doaj   +1 more source

Uncovering the Genetic Landscape of Spinal Dysraphism: A Retrospective Analysis of 150 Fetal Cases

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Spinal dysraphism (SD) results from incomplete neural tube closure and encompasses a heterogeneous group of congenital anomalies with genetic and environmental etiologies. Although genetic contributions are recognized, causative variants remain insufficiently defined, and the clinical implications of extended genetic testing on ...
I. Bedei, A. Feresin, R. Zemet, D. Berner, D. Polidori, K. Fröbius, A. Skakkebæk, R. Axt‐Fliedner, M. Shoukier, C. Keil   +9 more
wiley   +1 more source