Results 21 to 30 of about 5,306 (135)

A gene regulatory network for neural induction

eLife, 2023
During early vertebrate development, signals from a special region of the embryo, the organizer, can redirect the fate of non-neural ectoderm cells to form a complete, patterned nervous system.
Katherine E Trevers, Hui-Chun Lu, Youwen Yang, Alexandre P Thiery, Anna C Strobl, Claire Anderson, Božena Pálinkášová, Nidia MM de Oliveira, Irene M de Almeida, Mohsin AF Khan, Natalia Moncaut, Nicholas M Luscombe, Leslie Dale, Andrea Streit, Claudio D Stern   +14 more
doaj   +1 more source

Secondary neurulation mechanisms likely arose in vertebrates during mesenchymal tailbud extension

Frontiers in Cell and Developmental Biology
IntroductionThe central nervous system (CNS) is an essential organ system common to all vertebrates and is one of the defining features of the Chordata phylum.
Daiki Sugita, Alexis Lauga, Alexis Lauga, Martin Minařík, Martin Minařík, Lucy Barlow, Nicole Campbell, Michaela Vazačová, Martin Pšenička, Roman Franěk, Clare Buckley, Clare Buckley   +11 more
doaj   +1 more source

Molecular and morphogenetic features of neurulation

Zaporožskij Medicinskij Žurnal
Neurulation occurs by two different mechanisms, called primary and secondary neurulation. In humans, primary neurulation occurs along most of the rostrocaudal axis of the embryo, while secondary neurulation occurs caudally, only in the lower sacral and ...
N. M. Nevmerzhytska, O. M. Grabovyi, L. M. Yaremenko, I. V. Dzevulska, A. M. Synytska, H. I. Kozak   +5 more
doaj   +1 more source

Single-cell atlas of early chick development reveals gradual segregation of neural crest lineage from the neural plate border during neurulation

eLife, 2022
The epiblast of vertebrate embryos is comprised of neural and non-neural ectoderm, with the border territory at their intersection harboring neural crest and cranial placode progenitors.
Ruth M Williams, Martyna Lukoseviciute, Tatjana Sauka-Spengler, Marianne E Bronner   +3 more
doaj   +1 more source

The Birth of the Eye Vesicle: When Fate Decision Equals Morphogenesis

Frontiers in Neuroscience, 2018
As the embryonic ectoderm is induced to form the neural plate, cells inside this epithelium acquire restricted identities that will dictate their behavior and progressive differentiation.
Florence A. Giger, Corinne Houart
doaj   +1 more source

Maintenance of pluripotency-like signature in the entire ectoderm leads to neural crest stem cell potential

Nature Communications, 2023
The ability of the pluripotent epiblast to contribute progeny to all three germ layers is thought to be lost after gastrulation. The later-forming neural crest (NC) rises from ectoderm and it remains poorly understood how its exceptionally high stem-cell
Ceren Pajanoja, Jenny Hsin, Bradley Olinger, Andrew Schiffmacher, Rita Yazejian, Shaun Abrams, Arvydas Dapkunas, Zarin Zainul, Andrew D. Doyle, Daniel Martin, Laura Kerosuo   +10 more
doaj   +1 more source

Regulation of cell protrusions by small GTPases during fusion of the neural folds

eLife, 2016
Epithelial fusion is a crucial process in embryonic development, and its failure underlies several clinically important birth defects. For example, failure of neural fold fusion during neurulation leads to open neural tube defects including spina bifida.
Ana Rolo, Dawn Savery, Sarah Escuin, Sandra C de Castro, Hannah EJ Armer, Peter MG Munro, Matteo A Molè, Nicholas DE Greene, Andrew J Copp   +8 more
doaj   +1 more source

Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell–cell junctions during neural tube formation

Developmental Dynamics, EarlyView.
Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Derrick Thomas, Brittany M. Hufft‐Martinez, Zarna Lalwani, Vi Pham, Mary Elmeniawi, An J. Tran, Jianming Xu, Irfan Saadi, Walid D. Fakhouri   +8 more
wiley   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Cadherin preserves cohesion across involuting tissues during C. elegans neurulation

eLife, 2020
The internalization of the central nervous system, termed neurulation in vertebrates, is a critical step in embryogenesis. Open questions remain regarding how force propels coordinated tissue movement during the process, and little is known as to how ...
Kristopher M Barnes, Li Fan, Mark W Moyle, Christopher A Brittin, Yichi Xu, Daniel A Colón-Ramos, Anthony Santella, Zhirong Bao   +7 more
doaj   +1 more source