Results 31 to 40 of about 12,090 (225)

Regulation of cell protrusions by small GTPases during fusion of the neural folds

eLife, 2016
Epithelial fusion is a crucial process in embryonic development, and its failure underlies several clinically important birth defects. For example, failure of neural fold fusion during neurulation leads to open neural tube defects including spina bifida.
Ana Rolo, Dawn Savery, Sarah Escuin, Sandra C de Castro, Hannah EJ Armer, Peter MG Munro, Matteo A Molè, Nicholas DE Greene, Andrew J Copp   +8 more
doaj   +1 more source

Single-cell atlas of early chick development reveals gradual segregation of neural crest lineage from the neural plate border during neurulation

eLife, 2022
The epiblast of vertebrate embryos is comprised of neural and non-neural ectoderm, with the border territory at their intersection harboring neural crest and cranial placode progenitors.
Ruth M Williams, Martyna Lukoseviciute, Tatjana Sauka-Spengler, Marianne E Bronner   +3 more
doaj   +1 more source

Gene regulatory networks that control the specification of neural-crest cells in the lamprey [PDF]

, 2009
The lamprey is the only basal vertebrate in which large-scale gene perturbation analyses are feasible at present. Studies on this unique animal model promise to contribute both to the understanding of the basic neural-crest gene regulatory network ...
Bronner-Fraser, Marianne, Nikitina, Natalya V.   +1 more
core   +1 more source

Maintenance of pluripotency-like signature in the entire ectoderm leads to neural crest stem cell potential

Nature Communications, 2023
The ability of the pluripotent epiblast to contribute progeny to all three germ layers is thought to be lost after gastrulation. The later-forming neural crest (NC) rises from ectoderm and it remains poorly understood how its exceptionally high stem-cell
Ceren Pajanoja, Jenny Hsin, Bradley Olinger, Andrew Schiffmacher, Rita Yazejian, Shaun Abrams, Arvydas Dapkunas, Zarin Zainul, Andrew D. Doyle, Daniel Martin, Laura Kerosuo   +10 more
doaj   +1 more source

Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice. [PDF]

, 2015
Glycine decarboxylase (GLDC) acts in the glycine cleavage system to decarboxylate glycine and transfer a one-carbon unit into folate one-carbon metabolism. GLDC mutations cause a rare recessive disease non-ketotic hyperglycinemia (NKH).
Brosnan, JT, Brosnan, ME, Copp, AJ, Greene, ND, Heales, S, Hutchin, T, Leung, KY, Pai, YJ, Prunty, H, Savery, D   +9 more
core   +1 more source

Molecular and morphogenetic features of neurulation

Zaporožskij Medicinskij Žurnal
Neurulation occurs by two different mechanisms, called primary and secondary neurulation. In humans, primary neurulation occurs along most of the rostrocaudal axis of the embryo, while secondary neurulation occurs caudally, only in the lower sacral and ...
N. M. Nevmerzhytska, O. M. Grabovyi, L. M. Yaremenko, I. V. Dzevulska, A. M. Synytska, H. I. Kozak   +5 more
doaj   +1 more source

The distribution of Dishevelled in convergently extending mesoderm [PDF]

, 2013
Convergent extension (CE) is a conserved morphogenetic movement that drives axial lengthening of the primary body axis and depends on the planar cell polarity (PCP) pathway.
Bretschneider, Till, Green, Jeremy B.A., Panousopoulou, Eleni, Tyson, Richard A. (Richard Anthony)   +3 more
core   +1 more source

A Model for Investigating Developmental Eye Repair in Xenopus Laevis [PDF]

, 2018
Vertebrate eye development is complex and requires early interactions between neuroectoderm and surface ectoderm during embryogenesis. In the African clawed frog, Xenopus laevis, individual eye tissues such as the retina and lens can undergo regeneration.
Kha, Cindy X., Lauper, Julia, Son, Philip H., Tseng, Kelly Ai-Sun   +3 more
core   +2 more sources

Zic2 regulates the kinetics of neurulation [PDF]

Proceedings of the National Academy of Sciences, 2000
Mutation in human ZIC2, a zinc finger protein homologous to Drosophila odd-paired, causes holoprosencephaly (HPE), which is a common, severe malformation of the brain in humans. However, the pathogenesis is largely unknown. Here we show that reduced expression (knockdown) of mouse Zic2 causes
T, Nagai, J, Aruga, O, Minowa, T, Sugimoto, Y, Ohno, T, Noda, K, Mikoshiba   +6 more
openaire   +2 more sources

Cadherin preserves cohesion across involuting tissues during C. elegans neurulation

eLife, 2020
The internalization of the central nervous system, termed neurulation in vertebrates, is a critical step in embryogenesis. Open questions remain regarding how force propels coordinated tissue movement during the process, and little is known as to how ...
Kristopher M Barnes, Li Fan, Mark W Moyle, Christopher A Brittin, Yichi Xu, Daniel A Colón-Ramos, Anthony Santella, Zhirong Bao   +7 more
doaj   +1 more source