Results 91 to 100 of about 210,121 (261)

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia

American Journal of Physiology-Heart and Circulatory Physiology, 2011
Hyperglycemia in diabetes mellitus promotes oxidative stress in endothelial cells, which contributes to development of cardiovascular diseases. Nuclear factor erythroid 2-related factor-2 (Nrf2) is a transcription factor activated by oxidative stress that regulates expression of numerous reactive oxygen species (ROS) detoxifying and antioxidant genes.
Z. Ungvari, L. Bailey Downs, T. Gautam, G. Jimenez, G. Losonczy, C. Zhang, P. Ballabh, RECCHIA, FABIO ANASTASIO, D. C. Wilkerson, W. C. Sonntag, K. Pearson, R. de Cabo, A. Csiszar   +12 more
openaire   +4 more sources

NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2011
Objective— To test the hypothesis that NF-E2–related factor 2 (Nrf2) expression plays an antiatherogenic role by its vascular antioxidant and anti-inflammatory properties. Methods and Results— Nrf2 is an important transcription factor that regulates the expression of ...
Berenice, Barajas, Nam, Che, Fen, Yin, Amir, Rowshanrad, Luz D, Orozco, Ke Wei, Gong, Xuping, Wang, Lawrence W, Castellani, Karen, Reue, Aldons J, Lusis, Jesus A, Araujo   +10 more
openaire   +2 more sources

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

Developmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source

PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites. [PDF]

, 2012
Genome-wide association studies identified a PTGER4 expression-modulating region on chromosome 5p13.1 as Crohn's disease (CD) susceptibility region. The study aim was to test this association in a large cohort of patients with inflammatory bowel disease (
Darina Czamara, Richard H. Duerr (107855), M. Ilyas Kamboh (107850), Jean-Paul Achkar (107846), Andre Franke (77511), Giulia Pasciuto, Julia Seiderer (107820), Tobias Balschun, Giulia Pasciuto (107827), Seiderer, Julia, Pasciuto, Giulia, Glas, Jürgen, Duerr, Richard H., Bertram Müller-Myhsok, Tobias Balschun (77515), Richard H Duerr, Jürgen Glas (107816), Jean-Paul Achkar, Müller-Myhsok, Bertram, Christiane Wolf (107839), Bertram Müller-Myhsok (33498), Martin Wetzke, Torsten Olszak (107835), Brand, Stephan, Stephan Brand, Andre Franke, Franke, Andre, Czamara, Darina, Martin Wetzke (107833), Achkar, Jean-Paul, Julia Diegelmann (107830), Jürgen Glas, Christiane Wolf, Wetzke, Martin, Diegelmann, Julia, Wolf, Christiane, Balschun, Tobias, Darina Czamara (107824), Stephan Brand (107861), Julia Diegelmann, Torsten Olszak, Julia Seiderer, M Ilyas Kamboh, Kamboh, M. Ilyas, Olszak, Torsten   +44 more
core   +1 more source

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

Cellular and Molecular Gastroenterology and Hepatology, 2018
Nonalcoholic steatohepatitis (NASH) is associated with oxidative stress. We surmised that pharmacologic activation of NF-E2 p45-related factor 2 (Nrf2) using the acetylenic tricyclic bis(cyano enone) TBE-31 would suppress NASH because Nrf2 is a ...
Ritu S. Sharma, David J. Harrison, Dorothy Kisielewski, Diane M. Cassidy, Alison D. McNeilly, Jennifer R. Gallagher, Shaun V. Walsh, Tadashi Honda, Rory J. McCrimmon, Albena T. Dinkova-Kostova, Michael L.J. Ashford, John F. Dillon, John D. Hayes   +12 more
doaj   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Modulation of granulocyte-endothelium interactions by antileukoproteinase : inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium [PDF]

, 2006
Antileukoproteinase (ALP) is a physiological inhibitor of granulocytic serine proteases that has been shown to have anti-inflammatory properties in addition to its antiproteolytic activity.
Rikard Holmdahl, Kutty Nandakumar, Vollmar, Brigitte,, Sehnert, Bettina,, Harald Burkhardt, Rupert Hallmann, Hallmann, Rupert,, Anja Kühl, Reinhard Voll, Ibrahim, Saleh, Nandakumar, Kutty Selva,, Holmdahl, Rikard, Voll, Reinhard,, Burkhardt, Harald,, Gierer, Philip,, Bettina Sehnert, Burkhardt, Harald, Hallmann, Rupert, Saleh Ibrahim, Nandakumar, Kutty Selva, Vollmar, Brigitte, Ibrahim, Saleh,, Kühl, Anja,, Kuehl, Anja, Sehnert, Bettina, Philip Gierer, Gierer, Philip, Kühl, Anja, Lund University., Voll, Reinhard, Holmdahl, Rikard,, Brigitte Vollmar   +31 more
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source