Results 111 to 120 of about 151,448 (273)

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

open access: yesiNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little   +12 more
wiley   +1 more source

Quark mass thresholds in QCD thermodynamics

open access: yes, 2006
We discuss radiative corrections to how quark mass thresholds are crossed, as a function of the temperature, in basic thermodynamic observables such as the pressure, the energy and entropy densities, and the heat capacity of high temperature QCD.
B. Beinlich   +8 more
core   +1 more source

Low- and high-dose hydrogen peroxide regulation of transcription factor NF-E2-related factor 2.

open access: yesChinese medical journal, 2010
Reactive oxygen species (ROS) may play both physiological and pathophysiological roles. Transcription factor NF-E2-related factor 2 (Nrf2) regulates antioxidant response element (ARE)-mediated genes expression and coordinates induction of chemoprotective proteins in response to physical and chemical stresses.
Jiao-lin, Ning, Li-wen, Mo, Xi-nan, Lai
openaire   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

open access: yesiNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu   +5 more
wiley   +1 more source

Adenovirus-Mediated Over-Expression of Nrf2 Within Mesenchymal Stem Cells (MSCs) Protected Rats Against Acute Kidney Injury

open access: yesAdvanced Pharmaceutical Bulletin, 2015
Purpose: Recent developments in the field of cell therapy have led to a renewed interest in treatment of acute kidney injury (AKI). However, the early death of transplanted mesenchymal stem cells (MSCs) in stressful microenvironment of a recipient ...
Mohammad Mohammadzadeh-Vardin   +2 more
doaj   +1 more source

NF‐E2‐related factor 2 regulates the stress response to UVA‐1‐oxidized phospholipids in skin cells

open access: yesThe FASEB Journal, 2009
ABSTRACT Long‐wavelength ultraviolet (UVA‐1) radiation causes oxidative stress that modifies cellular molecules. To defend themselves against noxious oxidation products, skin cells produce detoxifying enzymes and antioxidants.
Florian, Gruber   +12 more
openaire   +3 more sources

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

open access: yesInterdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu   +6 more
wiley   +1 more source

Vortex-Strings in N=2 SQCD and Bulk-String Decoupling

open access: yes, 2017
We study vortex-strings in four-dimensional N=2 supersymmetric SU(Nc)xU(1) gauge theories with Nf hypermultiplets in the fundamental representation of SU(Nc) and general U(1) charges.
Gerchkovitz, Efrat, Karasik, Avner
core   +1 more source

Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen   +2 more
wiley   +1 more source

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