Results 111 to 120 of about 210,121 (261)

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Crystal structure of UBA2ufd-Ubc9: insights into E1-E2 interactions in sumo pathways [PDF]

, 2010
Canonical ubiquitin-like proteins (UBLs) such as ubiquitin, Sumo, NEDD8, and ISG15 are ligated to targets by E1-E2-E3 multienzyme cascades. The Sumo cascade, conserved among all eukaryotes, regulates numerous biological processes including protein ...
Miller, D.J., Asad M Taherbhoy, Schulman, B.A., Darcie J Miller, Steven N Seyedin, Huang Danny T., Wang, J., Kobe, B., Steven N. Seyedin, Seyedin Steven N., David W. Miller, Miller David W., Darcie J. Miller, Hunt Harold W., Miller, D.W., Taherbhoy, A.M., Danny T. Huang, Brenda A. Schulman, Miller Darcie J., Danny T Huang, Wang Jing, Harold W. Hunt, Harold W Hunt, Asad M. Taherbhoy, Schulman Brenda A., Jing Wang, Huang, D.T., Taherbhoy Asad M., David W Miller, Hunt, H.W., Seyedin, S.N., Brenda A Schulman   +31 more
core   +1 more source

Toxic Effects of Bisphenol A and Its Analogs on Ovarian Structure and Function: A Narrative Review of Ovary‐Focused Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is a widely used industrial chemical found in polycarbonate plastics and epoxy resins and is recognized for its endocrine‐disrupting properties. Human exposure is common due to its presence in food packaging and everyday products. As BPA use has been restricted, structurally similar compounds such as BPS, BPB, BPAF, and BADGE
Nurbanu Zengin, Marwa Tawfıq Ahmed Alsalım, Muhammed Canik, Sevda Bağdatlı, Nazan Deniz Yön   +4 more
wiley   +1 more source

Role of SUMO-1 modification in transcriptional activation [PDF]

, 2012
In unstimulated cells, the transcription factor NF-κB is held in the cytoplasm in an inactive state by IκB inhibitor proteins. Activation of NF--KB is mediated by signal induced degradation of IκBα via the ubiquitin proteasome-dependent pathway ...
Pinto Desterro, Maria Joana
core  

Adenovirus-Mediated Over-Expression of Nrf2 Within Mesenchymal Stem Cells (MSCs) Protected Rats Against Acute Kidney Injury

Advanced Pharmaceutical Bulletin, 2015
Purpose: Recent developments in the field of cell therapy have led to a renewed interest in treatment of acute kidney injury (AKI). However, the early death of transplanted mesenchymal stem cells (MSCs) in stressful microenvironment of a recipient ...
Mohammad Mohammadzadeh-Vardin, Mehryar Habibi Roudkenar, Ali Jahanian-Najafabadi   +2 more
doaj   +1 more source

Technology‐Driven Transformation of Compensation Systems: Mapping the Causal Structure of Digital Reward Systems

Strategic Change, EarlyView.
ABSTRACT Traditional reward systems, which are largely salary‐centered and structurally rigid, are no longer sufficient in an era defined by digital transformation. Building on this premise, this study examines how emerging technologies reshape integrated compensation systems by uncovering their causal, mediating, and outcome‐oriented roles.
Seyed Hossein Razavi Hajiagha, Hannan Amoozad Mahdiraji, Farzaneh Soltani, Gu Pang, Georgia Sakka, Salar Keshavarz Hedayati   +5 more
wiley   +1 more source

Monitoring Keap1-Nrf2 interactions in single live cells [PDF]

, 2014
The transcription factor NF-E2 p45-related factor 2 (Nrf2) and its negative regulator Kelch-like ECH associated protein 1 (Keap1) control the expression of nearly 500 genes with diverse cytoprotective functions.
Dinkova-Kostova, Albena, T, Baird, Liam, Llères, David, Swift, Sam, Dinkova-Kostova, Albena T.; id_orcid, Dinkova-Kostova, Albena T.   +5 more
core   +1 more source

Withdrawal: Sulforaphane attenuates muscle inflammation in dystrophin-deficient mdx mice via NF-E2-related factor 2 (Nrf2)-mediated inhibition of NF-κB signaling pathway. [PDF]

J Biol Chem, 2023
Sun CC, Li SJ, Yang CL, Xue RL, Xi YY, Wang L, Zhao QL, Li DJ.   +7 more
europepmc   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

p45 NF-E2 regulates syncytiotrophoblast differentiation by post-translational GCM1 modifications in human intrauterine growth restriction [PDF]

, 2017
Placental insufficiency jeopardizes prenatal development, potentially leading to intrauterine growth restriction (IUGR) and stillbirth. Surviving fetuses are at an increased risk for chronic diseases later in life.
Fahlbusch, Fabian, Lochmann, Franziska, Al-Dabet, Moh'd Mohanad, Ihsan Gadi, Ruebner, Matthias, Anat Aharon, Juliane Hoffmann, Huebner, Hanna, Fabian B Fahlbusch, Moh'd Mohanad Al-Dabet, Benjamin Brenner, Franziska Lochmann, Aharon, Anat, Gadi, Ihsan, Matthias Ruebner, Paulina Markmeyer, Michael Löttge, Shrey Kohli, Hoffmann, Juliane, Löttge, Michael, Ana C Zenclussen, Berend Isermann, Khurrum Shahzad, Brenner, Benjamin, Isermann, Berend, Kohli, Shrey, Zenclussen, Ana C., Jayakumar Manoharan, Hanna Huebner, Markmeyer, Paulina, Manoharan, Jayakumar, Shahzad, Khurrum   +31 more
core   +1 more source