Results 121 to 130 of about 151,448 (273)

Early Dapagliflozin and Melatonin Treatment Ameliorated LV Fibrosis via Suppressing TGF‐β1/Smads and Activating Nrf2‐ARE Signaling in MI Rodent

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study tested whether combined dapagliflozin (DAPA) and melatonin (Mel) therapy was superior to merely one for ameliorating the left ventricular (LV) fibrosis/remodeling and improving LV ejection fraction (LVEF) in rats after acute myocardial infarction (AMI). In vitro study demonstrated that DAPA treatment significantly suppressed the TGF‐
Jiunn‐Jye Sheu   +6 more
wiley   +1 more source

Ginsenoside Rb1 Attenuates Intestinal Ischemia Reperfusion Induced Renal Injury by Activating Nrf2/ARE Pathway

open access: yesMolecules, 2012
Intestinal ischemia reperfusion (IIR) is a serious clinical condition associated with simultaneous multiple organ dysfunction. The aim of this study was to investigate the effects of ginsenoside Rb1 on IIR induced renal injury in mice.
Zhong-Yuan Xia   +3 more
doaj   +1 more source

Topologically Twisted SUSY Gauge Theory, Gauge-Bethe Correspondence and Quantum Cohomology

open access: yes, 2019
We calculate partition function and correlation functions in A-twisted 2d $\mathcal{N}=(2,2)$ theories and topologically twisted 3d $\mathcal{N}=2$ theories containing adjoint chiral multiplet with particular choices of $R$-charges and the magnetic ...
Chung, Hee-Joong, Yoshida, Yutaka
core   +1 more source

3-Bromo-4,5-dihydroxybenzaldehyde Enhances the Level of Reduced Glutathione via the Nrf2-Mediated Pathway in Human Keratinocytes

open access: yesMarine Drugs, 2017
A natural bromophenol found in seaweeds, 3-bromo-4,5-dihydroxybenzaldehyde (BDB), has been shown to possess antioxidant effects. This study aimed to investigate the mechanism by which BDB protects skin cells subjected to oxidative stress.
Ki Cheon Kim   +8 more
doaj   +1 more source

Discrete theta angle from an O5-plane

open access: yes, 2017
We consider 5d $\mathcal{N}=1$ $Sp(1)$ gauge theory based on a brane configuration with an O5-plane. At the UV fixed point, the theory with no matter enjoys enhanced global symmetry $SU(2)$ or $U(1)$ depending on the discrete theta angle $\theta=0, \pi$ (
Hayashi, Hirotaka   +3 more
core   +1 more source

Recurrent Respiratory Papillomatosis Foundation Position Statement on the Management of Adults With RRP

open access: yesThe Laryngoscope, EarlyView.
ABSTRACT Objective With regulatory approval of HPV‐specific immunotherapy for recurrent respiratory papillomatosis (RRP) and growing experience with systemic bevacizumab, a management algorithm incorporating these medical treatments is warranted. Data Sources and Methods RRP Foundation (RRPF) Key Opinion Leaders offer a proposed management algorithm ...
Simon R. Best   +17 more
wiley   +1 more source

Fucoxanthin Enhances the Level of Reduced Glutathione via the Nrf2-Mediated Pathway in Human Keratinocytes

open access: yesMarine Drugs, 2014
Fucoxanthin, a natural carotenoid, is abundant in seaweed with antioxidant properties. This study investigated the role of fucoxanthin in the induction of antioxidant enzymes involved in the synthesis of reduced glutathione (GSH), synthesized by ...
Jian Zheng   +5 more
doaj   +1 more source

Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia

open access: yesAmerican Journal of Physiology-Heart and Circulatory Physiology, 2011
Hyperglycemia in diabetes mellitus promotes oxidative stress in endothelial cells, which contributes to development of cardiovascular diseases. Nuclear factor erythroid 2-related factor-2 (Nrf2) is a transcription factor activated by oxidative stress that regulates expression of numerous reactive oxygen species (ROS) detoxifying and antioxidant genes.
Z. Ungvari   +12 more
openaire   +4 more sources

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

open access: yesMed Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang   +12 more
wiley   +1 more source

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