Results 141 to 150 of about 151,448 (273)

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Hamiltonian Theory of the FQHE: Conserving Approximation for Incompressible Fractions

, 2001
A microscopic Hamiltonian theory of the FQHE developed by Shankar and the present author based on the fermionic Chern-Simons approach has recently been quite successful in calculating gaps and finite tempertature properties in Fractional Quantum Hall ...
A. Lopez, A. Lopez, A. Lopez, A. Stern, A.H. MacDonald, A.S. Goldhaber, B.I. Halperin, B.I. Halperin, B.I. Halperin, C. Kallin, C.L. Kane, D. Bohm, D. Tsui, D. Yoshioka, D.-H. Lee, D.H. Lee, F.C. Zhang, F.D.M. Haldane, F.D.M. Haldane, F.F. Fang, G. Baym, G. Murthy, G. Murthy, G. Murthy, G. Murthy, G. Murthy, G. Rickayzen, Ganpathy Murthy, H.C.A. Oji, I.K. Marmorkos, J.K. Jain, J.K. Jain, J.K. Jain, J.K. Jain, J.M. Caillol, J.M. Leinaas, J.P. Longo, K.W. Chiu, L.P. Kadanoff, M. Baus, N. d’Ambrumenil, N. Horing, N. Read, N. Read, N. Read, N. Read, P. Hawrylak, P.M. Platzman, R. Morf, R. Price, R. Shankar, R. Shankar, R. Shankar, R.B. Laughlin, R.K. Kamilla, R.K. Kamilla, S. He, S.-C. Zhang, S.-C. Zhang, S.H. Simon, S.H. Simon, S.L. Sondhi, S.M. Girvin, S.M. Girvin, S.M. Grivin, T. Ando, T. Chakraborty, T. Theis, V. Kalmeyer, V. Pasquier, W. Kohn, W.P. Su, X.G. Wu, Yu.A. Bychkov   +73 more
core   +1 more source

CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis

Cell Proliferation, EarlyView.
CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng, Dihao Tao, Wenzhe Wang, Huiyu Wang, Hanzhe Wang, Yufan Liang, Jia Guo, Wenhao Liu, Yiming Wang, Jianhua Yang, Xiaoning He, Ce Shan, Bei Li   +12 more
wiley   +1 more source

Effect of aging on healing of mandibular tooth extraction socket in a rat model

European Journal of Oral Sciences, EarlyView.
Abstract This study evaluated the effect of aging on bone regeneration in mandibular extraction sockets. Male Sprague–Dawley rats were divided into three age groups: 2‐month‐old (2 M, n = 6), 10‐month‐old (10 M, n = 6), and 18‐month‐old (18 M, n = 5). Two weeks post‐extraction, comprehensive analyses were performed using micro‐computed tomography (µ‐CT)
Kyung Su Shin, Han Wool Kwak, Jong‐Seong Chae, Si‐On Choi, Suah Han, Hwa Young Yu, Dae Ho Leem, Hyun Seok   +7 more
wiley   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Decoding stress resilience in soybean: Regulatory networks and precision breeding under climate change

Journal of Integrative Plant Biology, EarlyView.
This review covers recent progress in the understanding of stress‐responsive regulatory networks in soybean and highlights emerging genomic and breeding strategies. Integrating molecular insights and precision breeding will help to accelerate the development of climate‐resilient soybean cultivars.
Ali Shahzad, Monan Sun, Shuangkang Pei, Xiaoyu Liu, Yinhe Zhang, Keheng Xu, Hongtao Gao, Yonggang Zhou, Haiyan Li   +8 more
wiley   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

AURKA Suppresses Ferroptosis via the KEAP1/NRF2/HO‑1 Axis in EGFR-Mutant Lung Adenocarcinoma

Frontiers in Bioscience-Landmark
Background: Adenocarcinoma of Lung (LUAD) remains a leading cause of cancer-related deaths across the globe, and patients harboring epidermal growth factor receptor (EGFR) mutations frequently develop resistance to targeted therapies ...
Yufeng Huang, Gengqiu Liu, Zhu Liang, Junhang Zhang   +3 more
doaj   +1 more source

NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes. [PDF]

Glia, 2020
Oksanen M, Hyötyläinen I, Trontti K, Rolova T, Wojciechowski S, Koskuvi M, Viitanen M, Levonen AL, Hovatta I, Roybon L, Lehtonen Š, Kanninen KM, Hämäläinen RH, Koistinaho J.   +13 more
europepmc   +1 more source