Cancer Science, EarlyView.Schematic illustration of the mechanisms by which the natural quassinoid brusatol induces apoptosis in myeloid leukemias and enhances venetoclax efficacy via p53‐dependent apoptosis and mitochondrial dysfunction. ABSTRACT While venetoclax‐based combinations have shown promising results in acute myeloid leukemia (AML), the remission duration is ...
Shin‐ichiro Kawaguchi +11 more
wiley +1 more source
AURKA Suppresses Ferroptosis via the KEAP1/NRF2/HO‑1 Axis in EGFR-Mutant Lung Adenocarcinoma
Frontiers in Bioscience-LandmarkBackground: Adenocarcinoma of Lung (LUAD) remains a leading cause of cancer-related deaths across the globe, and patients harboring epidermal growth factor receptor (EGFR) mutations frequently develop resistance to targeted therapies ...
Yufeng Huang +3 more
doaj +1 more source
CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis
Cell Proliferation, EarlyView.CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng +12 more
wiley +1 more source
NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes. [PDF]
Glia, 2020 Oksanen M +13 more
europepmc +1 more source
Cell Proliferation, EarlyView.Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao +7 more
wiley +1 more source
An investigation into the mechanisms by which bim gene expression is regulated in sympathetic neurons [PDF]
, 2010 Neuronal apoptosis plays a critical role in development and disease. Developing sympathetic neurons require nerve growth factor (NGF) for their survival and die by apoptosis in its absence.
Hughes, R.
core
Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease
Cell Proliferation, EarlyView.Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik +10 more
wiley +1 more source
Biogenesis of TNF‐α‐insights into proteostasis and inflammation
The FEBS Journal, EarlyView.TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar +3 more
wiley +1 more source
The role of transcription factor NF-E2 in mediating erythrocytosis and thrombocytosis of myeloproliferative diseases [PDF]
, 2011 Die myeloproliferativen Erkrankungen (MPD) Polyzythämia Vera (PV), Essentielle Thrombozythämie (ET) und Primäre Myelofibrose (PMF) sind durch eine deregulierte klonale Expansion reifer Blutzellen gekennzeichnet.
Bürge, Martina
core
Erratum: Sirtuin 1 Promotes Hyperoxide-Induced Lung Epithelial Cell Death Independent of NF-E2-Related Factor 2 Activation. [PDF]
Am J Respir Cell Mol Biol, 2021 europepmc +1 more source