Neuroprotective and Antioxidant Properties of CholesteroNitrone ChN2 and QuinolylNitrone QN23 in an Experimental Model of Cerebral Ischemia: Involvement of Necrotic and Apoptotic Cell Death [PDF]
Antioxidants, 2023 Ischemic stroke is the leading cause of disability and the second leading cause of death worldwide. However, current therapeutic strategies are scarce and of limited efficacy.
Beatriz Chamorro +6 more
doaj +2 more sources
Total Synthesis of Isodaphlongamine H by Iridium‐Catalyzed Reductive [3 + 2] Cycloaddition of N‐Hydroxylactam [PDF]
Angewandte Chemie, Volume 137, Issue 29, July 14, 2025.The total synthesis of isodaphlongamine H was accomplished by a lactam strategy. This strategy started with alkylation and N‐oxidation of a readily available chiral lactam. For the key functionalization of the amide carbonyl, an iridium‐catalyzed reductive [3 + 2] cycloaddition of the N‐hydroxylactam afforded the tricyclic isoxazolidine, which was ...
Sora Iwamoto +15 more
wiley +3 more sources
α-Phenyl-N-tert-Butylnitrone and Analogous α-Aryl-N-alkylnitrones as Neuroprotective Antioxidant Agents for Stroke [PDF]
AntioxidantsThe recent advances in research on the use of the antioxidant and neuroprotective agent α-phenyl-N-tert-butylnitrone (PBN) for the therapy of stroke have been reviewed. The protective effect of PBN in the transient occlusion of the middle cerebral artery
José Marco-Contelles
doaj +2 more sources
Synthesis of Sterically Shielded Nitroxides Using the Reaction of Nitrones with Alkynylmagnesium Bromides [PDF]
Molecules, 2022 Sterically shielded nitroxides, which demonstrate high resistance to bioreduction, are the spin labels of choice for structural studies inside living cells using pulsed EPR and functional MRI and EPRI in vivo.
Sergey A. Dobrynin +8 more
doaj +2 more sources
Polyfunctionalized α-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment [PDF]
Antioxidants, 2022 Nowadays, most stroke patients are treated exclusively with recombinant tissue plasminogen activator, a drug with serious side effects and limited therapeutic window. For this reason, and because of the known effects of oxidative stress on stroke, a more
Daniel Diez-Iriepa +8 more
doaj +2 more sources
In Vitro Modulation of Autophagy by New Antioxidant Nitrones as a Potential Therapeutic Approach for the Treatment of Ischemic Stroke [PDF]
AntioxidantsStroke is a leading cause of death worldwide, yet current therapeutic strategies remain limited. Among the neuropathological events underlying this disease are multiple cell death signaling cascades, including autophagy.
Sara Izquierdo-Bermejo +6 more
doaj +2 more sources
A new role of N-arylbenzoquinoneimine N-oxides in the von Richter reaction [PDF]
Journal of the Serbian Chemical Society, 2006 The title nitrones react with cyanide ions to give benzoic acids and N-aryl-4-hydroxy-2-cyanophenylamines via two different pathways.
Karami Bahador +3 more
doaj +3 more sources
Science Journal of University of Zakho, 2023 Synthetic approached towards the synthesis of some novel nitrones derivatives have been started with reduction of nitrobenzene derivatives as starting material bearing electron withdrawing and electron donating groups to corresponding ...
Jihad Haji Mohammed +1 more
doaj +1 more source
Science Journal of University of Zakho, 2022 Synthetic approached towards the synthesis of some novel nitrones derivatives have been started with reduction of nitrobenzene derivatives as starting material bearing electron withdrawing and electron donating groups to corresponding phenylhydroxylamine
Jihad Haji Mohammed +1 more
doaj +1 more source
Molecules, 2022 Pyrrolidine nitroxides with four bulky alkyl substituents adjacent to N–O group are known for their high resistance to bioreduction. The 3,4-unsubstituted 2-tert-butyl-2-ethylpyrrolidine-1-oxyls were prepared from the corresponding 2-tert-butyl-1 ...
Andrey I. Taratayko +4 more
doaj +1 more source