Recent Advances to Augment NK Cell Cancer Immunotherapy Using Nanoparticles
Pharmaceutics, 2021 Among various immunotherapies, natural killer (NK) cell cancer immunotherapy using adoptive transfer of NK cells takes a unique position by targeting tumor cells that evade the host immune surveillance. As the first-line innate effector cell, it has been
Kwang-Soo Kim +2 more
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Differential Targeting of Stem Cells and Differentiated Glioblastomas by NK Cells. [PDF]
, 2015 We have recently shown that Natural Killer (NK) cells control survival and differentiation of Cancer Stem-like Cells (CSCs) through two distinct phenotypes of cytotoxic and anergic NK cells, respectively. In this report, brain CSCs and their serum and NK
Bui, Vickie T +6 more
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What Defines NK Cell Functional Fate: Phenotype or Metabolism?
Frontiers in Immunology, 2019 NK cells are capable of an array of functions that range widely from their classic anti-tumor and anti-viral cytotoxic effector functions, to their critical regulatory roles in controlling inflammatory immune responses and promoting tissue growth ...
Sophie M. Poznanski, Ali A. Ashkar
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Effector Functions of Natural Killer Cell Subsets in the Control of Hematological Malignancies. [PDF]
, 2015 Treatment of hematological malignant disorders has been improved over the last years, but high relapse rate mainly attributable to the presence of minimal residual disease still persists.
Biassoni +67 more
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Checkpoint TIPE2 Limits the Helper Functions of NK Cells in Supporting Antitumor CD8+ T Cells
Advanced Science, 2023 Natural killer (NK) cells not only are innate effector lymphocytes that directly participate in tumor surveillance but are also essential helpers in the antitumor CD8+ T‐cell response.
Jiacheng Bi +7 more
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Identification of a porcine liver eomes-high-T-bet-low NK cell subset that resembles human liver resident NK cells [PDF]
, 2019 Natural killer (NK) cells are cells of the innate immunity and play an important role in the defense against viral infections and cancer, but also contribute to shaping adaptive immune responses. Long-lived tissue-resident NK cells have been described in
De Pelsmaeker, Steffi +3 more
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Alteration in blood leukocyte profile due to exercise and its implication
Journal of Physical Fitness and Sports Medicine, 2013 Evaluation of peripheral blood leukocytes has been considered a popular window to the immune system and its response. The numeration of leukocytes has long been a practical clinical marker of acute inflammation.
Ryoichi Nagatomi
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Feeder Cells at the Interface of Natural Killer Cell Activation, Expansion and Gene Editing
Frontiers in Immunology, 2022 Genome engineered natural killer (NK) cell therapies are emerging as a promising cancer immunotherapy platform with potential advantages and remaining uncertainties.
Mark Gurney +5 more
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Bortezomib Augments Natural Killer Cell Targeting of Stem-Like Tumor Cells. [PDF]
, 2019 Tumor cells harboring stem-like/cancer stem cell (CSC) properties have been identified and isolated from numerous hematological and solid malignancies.
Ames, Erik +8 more
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Building a Better Defense: Expanding and Improving Natural Killer Cells for Adoptive Cell Therapy
CellsNatural killer (NK) cells have gained attention as a promising adoptive cell therapy platform for their potential to improve cancer treatments. NK cells offer distinct advantages over T-cells, including major histocompatibility complex class I (MHC-I ...
Andreia Maia +7 more
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