Results 51 to 60 of about 628,729 (310)
Frontiers in Immunology, 2018 BackgroundNatural killer (NK) cells are known to mount a response against foreign target cells, where the absence of the dominant inhibitory killer Ig-like receptor (KIR)–human leukocyte antigen (HLA) interaction immensely lowers the threshold for NK ...
Jef Hens +6 more
doaj +1 more source
Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]
, 2017 Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana +5 more
core +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Natural Killer Cell-Mediated Cellular Therapy of Hematological Malignancies
Clinical Hematology International, 2019 Our understanding on the mechanisms of graft versus tumor/leukemia (GvT/GvL) and graft versus host (GvH) effects has tremendously evolved within the past decades.
Ugur Sahin, Meral Beksac
doaj +1 more source
Development and implementation of natural killer cell simultaneous ADCC and direct killing assay
Heliyon, 2023 Assays to quantify natural killer (NK) cell killing efficacy have traditionally focused on assessing either direct killing or antibody dependent cell-mediated cytotoxicity (ADCC) independently.
Maia M.C. Bennett-Boehm +14 more
doaj +1 more source
The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF [PDF]
, 2019 The ubiquitin-editing enzyme A20 is a well-known regulator of immune cell function and homeostasis. In addition, A20 protects cells from death in an ill-defined manner.
Boon, Louis +17 more
core +6 more sources
Paired NK cell receptors controlling NK cytotoxicity
FEBS Letters, 2010 Human natural killer (NK) cells possess an arsenal of receptors programmed to regulate the NK cell functions, once encountering a target cell. In general, the activating receptors mediate cytotoxicity when engaged by their tumor specific, stress induced, virally encoded, or rarely, self ligands.
Stanietsky, Noa, Mandelboim, Ofer
openaire +2 more sources
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Tumor-primed natural killer cells: waiting for the green light
Frontiers in Immunology, 2013 The functional impairment of natural killer (NK) cells has been frequently reported in cancer studies. As one of the central components of host anti-tumor immunity, NK cells exert cellular cytotoxicity against tumor cells, and secrete a cytokine milieu ...
May eSabry, Mark W. Lowdell
doaj +1 more source
Single-Cell Sequencing Reveals the Novel Role of Ezh2 in NK Cell Maturation and Function
Frontiers in Immunology, 2021 Natural killer (NK) cells are lymphocytes primarily involved in innate immunity and exhibit important functional properties in antimicrobial and antitumoral responses.
Minghang Yu +6 more
doaj +1 more source