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NKG2D ligands in tumor immunity [PDF]
Oncogene, 2008 The activating receptor NKG2D (natural-killer group 2, member D) and its ligands play an important role in the NK, gammadelta(+) and CD8(+) T-cell-mediated immune response to tumors. Ligands for NKG2D are rarely detectable on the surface of healthy cells and tissues, but are frequently expressed by tumor cell lines and in tumor tissues.
Adelheid Cerwenka, Norman Nausch
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Genetics, genomics, and evolutionary biology of NKG2D ligands
Immunological Reviews, 2015Seiamak Bahram
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An integrated view of the regulation of NKG2D ligands [PDF]
Immunology, 2009 SummaryNKG2D is one of the best characterized activating receptors and is expressed on natural killer cells and on various T‐cell subsets. This receptor recognizes several different ligands that are induced by cellular stresses. In this review, we described the mechanisms controlling the expression of NKG2D ligands, with the emphasis on post ...
Ofer Mandelboim
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The FASEB Journal, 2020
SCFAs are primarily produced in the colon by bacterial fermentation of nondigestible carbohydrates. Besides providing energy, SCFAs can suppress development of colon cancer. The mechanism, however, remains elusive.
R. I. Høgh +8 more
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SCFAs are primarily produced in the colon by bacterial fermentation of nondigestible carbohydrates. Besides providing energy, SCFAs can suppress development of colon cancer. The mechanism, however, remains elusive.
R. I. Høgh +8 more
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The International Journal of Biochemistry & Cell Biology, 2009
NKG2D is an activating immunoreceptor, first recognized on NK cells but subsequently found on gammadelta T cells, CD8(+) alphabeta T cells and macrophages. In NK cells, inhibitory signals are generally dominate over activating signals. However, activating signals mediated through engagement of NKG2D by its ligands on target cells can bypass signals ...
Peyman, Obeidy, Alexandra F, Sharland
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NKG2D is an activating immunoreceptor, first recognized on NK cells but subsequently found on gammadelta T cells, CD8(+) alphabeta T cells and macrophages. In NK cells, inhibitory signals are generally dominate over activating signals. However, activating signals mediated through engagement of NKG2D by its ligands on target cells can bypass signals ...
Peyman, Obeidy, Alexandra F, Sharland
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Roles of the NKG2D immunoreceptor and its ligands
Nature Reviews Immunology, 2003According to present concepts, innate immunity is regulated by receptors that determine danger levels by responding to molecules that are associated with infection or cellular distress. NKG2D is, perhaps, the best characterized receptor that is associated with responses to cellular distress, defined as transformation, infection or cell stress.
David Raulet, Raulet David H
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ULBP4 is a novel ligand for human NKG2D
Biochemical and Biophysical Research Communications, 2003The ULBPs are a family of MHC class I-related molecules. We have previously shown that ULBPs 1, 2, and 3 are functional ligands of the NKG2D/DAP10 receptor complex on human natural killer (NK) cells. Here, we describe a new member of the ULBP family, ULBP4, which contains predicted transmembrane and cytoplasmic domains, unlike the other ULBPs, which ...
N Jan, Chalupny +4 more
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Immunogenetics of the NKG2D ligand gene family
Immunogenetics, 2012NKG2D ligands (NKG2DLs) are a group of major histocompatibility complex (MHC) class I-like molecules, the expression of which is induced by cellular stresses such as infection, tumorigenesis, heat shock, tissue damage, and DNA damage. They act as a molecular danger signal alerting the immune system for infected or neoplastic cells.
Masanori, Kasahara, Shigeru, Yoshida
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Importance of NKG2D-NKG2D ligands interaction for cytolytic activity of natural killer cell
Cellular Immunology, 2012In this study, we investigate the relationship between natural killer (NK) cell susceptibility and the surface markers of cancer cells. Through phenotypic analysis, we found evidence that more susceptible cancer cell lines (K562 and Jurkat) express more NKG2D ligands.
Yu Kyeong Hwang, Jae Kwon Lee
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