Results 161 to 170 of about 381,426 (191)

Regulation of NKG2D Ligand Gene Expression

Human Immunology, 2006
The activating immunoreceptor NKG2D has seven known host ligands encoded by the MHC class I chain-related MIC and ULBP/RAET genes. Why there is such diversity of NKG2D ligands is not known but one hypothesis is that they are differentially expressed in different tissues in response to different stresses. To explore this, we compared expression patterns
Mark R Wills, John Trowsdale, James A Traherne   +2 more
exaly   +3 more sources

Immunogenetics of the NKG2D ligand gene family

Immunogenetics, 2012
NKG2D ligands (NKG2DLs) are a group of major histocompatibility complex (MHC) class I-like molecules, the expression of which is induced by cellular stresses such as infection, tumorigenesis, heat shock, tissue damage, and DNA damage. They act as a molecular danger signal alerting the immune system for infected or neoplastic cells.
Masanori, Kasahara, Shigeru, Yoshida
openaire   +2 more sources

ULBP4 is a novel ligand for human NKG2D

Biochemical and Biophysical Research Communications, 2003
The ULBPs are a family of MHC class I-related molecules. We have previously shown that ULBPs 1, 2, and 3 are functional ligands of the NKG2D/DAP10 receptor complex on human natural killer (NK) cells. Here, we describe a new member of the ULBP family, ULBP4, which contains predicted transmembrane and cytoplasmic domains, unlike the other ULBPs, which ...
N Jan, Chalupny, Claire L, Sutherland, William A, Lawrence, Annie, Rein-Weston, David, Cosman   +4 more
openaire   +2 more sources

The expression of NKG2D ligand is induced in the cutaneous ischemia-reperfusion injury and mitigates pressure ulcer via NKG2D-NKG2D ligand interaction

The Journal of Immunology, 2020
Abstract NKG2D is an activating receptor on NK cells, NKT cells, and several types of T-cells. The ligands for NKG2D are expressed on distressed cells, and NKG2D-NKG2D ligand interaction plays a major role in the surveillance against tumors and viral infection. Several studies have reported the physiological role of NKG2D-positive cells,
Noriyuki Otsuka, Keishi Makita, Utano Tomaru, Masanori Kasahara   +3 more
openaire   +1 more source

Immunobiology of Human NKG2D and Its Ligands

2006
The NKG2D-DAP10 receptor complex activates natural killer (NK) cells and costimulates effector T cell subsets upon engagement of ligands that can be conditionally expressed under physiologically harmful conditions such as microbial infections and malignancies. These characteristics have given rise to the widely embraced concept of immunorecognition of "
S, González, V, Groh, T, Spies
openaire   +2 more sources

Viral inhibitors of NKG2D ligands for tumor surveillance

Expert Opinion on Therapeutic Targets, 2016
Natural Killer cells (NK) are key for the innate immune response against tumors and viral infections. Several viral proteins evade host immune response and target the NK cell receptor NKG2D and its ligands. Areas covered: This review aimed to describe the viruses and their proteins that interfere with the NKG2D receptor and their ligands, and how these
Alma, Chávez-Blanco, Rommel, Chacón-Salinas, Guadalupe, Dominguez-Gomez, Aurora, Gonzalez-Fierro, Enrique, Perez-Cardenas, Lucia, Taja-Chayeb, Catalina, Trejo-Becerril, Alfonso, Duenas-Gonzalez   +7 more
openaire   +2 more sources

Arming cytotoxic lymphocytes for cancer immunotherapy by means of the NKG2D/NKG2D-ligand system

Expert Opinion on Biological Therapy, 2020
The activating NKG2D receptor plays a central role in the immune recognition and elimination of abnormal self-cells by cytotoxic lymphocytes. NKG2D binding to cell stress-inducible ligands (NKG2DL) up-regulated on cancer cells facilitates their immunorecognition. Yet tumor cells utilize various escape mechanisms to avert NKG2D-based immunosurveillance.
Mariya Lazarova, Winfried S. Wels, Alexander Steinle   +2 more
openaire   +2 more sources

Importance of NKG2D-NKG2D ligands interaction for cytolytic activity of natural killer cell

Cellular Immunology, 2012
In this study, we investigate the relationship between natural killer (NK) cell susceptibility and the surface markers of cancer cells. Through phenotypic analysis, we found evidence that more susceptible cancer cell lines (K562 and Jurkat) express more NKG2D ligands.
Deok Sung, Bae, Yu Kyeong, Hwang, Jae Kwon, Lee   +2 more
openaire   +2 more sources

Roles of the NKG2D immunoreceptor and its ligands

Nature Reviews Immunology, 2003
According to present concepts, innate immunity is regulated by receptors that determine danger levels by responding to molecules that are associated with infection or cellular distress. NKG2D is, perhaps, the best characterized receptor that is associated with responses to cellular distress, defined as transformation, infection or cell stress.
openaire   +2 more sources

How NKG2D Ligands Trigger Autoimmunity?

Human Immunology, 2006
The function of NK and CD8 T cells in the elimination of infected, transformed, or stressed cells occurs together with tolerance to self, a property that is essential to prevent autoimmunity. Inappropriate expression of NK receptor ligands, leading to activation of autoreactive effector cells, might therefore trigger or exacerbate autoimmunity.
openaire   +2 more sources