Results 161 to 170 of about 1,053,112 (188)

Regulation of NKG2D Ligand Gene Expression

Human Immunology, 2006
The activating immunoreceptor NKG2D has seven known host ligands encoded by the MHC class I chain-related MIC and ULBP/RAET genes. Why there is such diversity of NKG2D ligands is not known but one hypothesis is that they are differentially expressed in different tissues in response to different stresses. To explore this, we compared expression patterns
Robert A, Eagle, James A, Traherne, Omodele, Ashiru, Mark R, Wills, John, Trowsdale   +4 more
openaire   +2 more sources

The expression of NKG2D ligand is induced in the cutaneous ischemia-reperfusion injury and mitigates pressure ulcer via NKG2D-NKG2D ligand interaction

The Journal of Immunology, 2020
Abstract NKG2D is an activating receptor on NK cells, NKT cells, and several types of T-cells. The ligands for NKG2D are expressed on distressed cells, and NKG2D-NKG2D ligand interaction plays a major role in the surveillance against tumors and viral infection. Several studies have reported the physiological role of NKG2D-positive cells,
Noriyuki Otsuka, Keishi Makita, Utano Tomaru, Masanori Kasahara   +3 more
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Immunobiology of Human NKG2D and Its Ligands

2006
The NKG2D-DAP10 receptor complex activates natural killer (NK) cells and costimulates effector T cell subsets upon engagement of ligands that can be conditionally expressed under physiologically harmful conditions such as microbial infections and malignancies. These characteristics have given rise to the widely embraced concept of immunorecognition of "
S, González, V, Groh, T, Spies
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Activation of liver X receptor up‐regulates the expression of the NKG2D ligands MICA and MICB in multiple myeloma through different molecular mechanisms

The FASEB Journal, 2019
NK cells have an important role in immunosurveillance of multiple myeloma (MM) progression, and their activity is enhanced by combination therapies able to regulate the expression of specific activating ligands.
M. Bilotta, Maria Pia Abruzzese, R. Molfetta, Gianluca Scarno, C. Fionda, A. Zingoni, A. Soriani, T. Garofalo, M. Petrucci, M. R. Ricciardi, R. Paolini, A. Santoni, M. Cippitelli   +12 more
semanticscholar   +1 more source

Arming cytotoxic lymphocytes for cancer immunotherapy by means of the NKG2D/NKG2D-ligand system

Expert Opinion on Biological Therapy, 2020
The activating NKG2D receptor plays a central role in the immune recognition and elimination of abnormal self-cells by cytotoxic lymphocytes. NKG2D binding to cell stress-inducible ligands (NKG2DL) up-regulated on cancer cells facilitates their immunorecognition. Yet tumor cells utilize various escape mechanisms to avert NKG2D-based immunosurveillance.
Mariya Lazarova, Winfried S. Wels, Alexander Steinle   +2 more
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How NKG2D Ligands Trigger Autoimmunity?

Human Immunology, 2006
The function of NK and CD8 T cells in the elimination of infected, transformed, or stressed cells occurs together with tolerance to self, a property that is essential to prevent autoimmunity. Inappropriate expression of NK receptor ligands, leading to activation of autoreactive effector cells, might therefore trigger or exacerbate autoimmunity.
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NKG2D ligands: key targets of the immune response

Trends in Immunology, 2008
NKG2D is an activating receptor expressed by NK and T cells. NKG2D ligands show a restricted expression in normal tissues, but they are frequently overexpressed in cancer and infected cells. The binding of NKG2D to its ligands activates NK and T cells and promotes cytotoxic lysis of the cells expressing these molecules.
Segundo, González, Alejandro, López-Soto, Beatriz, Suarez-Alvarez, Antonio, López-Vázquez, Carlos, López-Larrea   +4 more
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Viral inhibitors of NKG2D ligands for tumor surveillance

Expert Opinion on Therapeutic Targets, 2016
Natural Killer cells (NK) are key for the innate immune response against tumors and viral infections. Several viral proteins evade host immune response and target the NK cell receptor NKG2D and its ligands. Areas covered: This review aimed to describe the viruses and their proteins that interfere with the NKG2D receptor and their ligands, and how these
Alma, Chávez-Blanco, Rommel, Chacón-Salinas, Guadalupe, Dominguez-Gomez, Aurora, Gonzalez-Fierro, Enrique, Perez-Cardenas, Lucia, Taja-Chayeb, Catalina, Trejo-Becerril, Alfonso, Duenas-Gonzalez   +7 more
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NKG2D ligands as therapeutic targets.

Cancer immunity, 2014
The Natural Killer Group 2D (NKG2D) receptor plays an important role in protecting the host from infections and cancer. By recognizing ligands induced on infected or tumor cells, NKG2D modulates lymphocyte activation and promotes immunity to eliminate ligand-expressing cells. Because these ligands are not widely expressed on healthy adult tissue, NKG2D
Paul, Spear, Ming-Ru, Wu, Marie-Louise, Sentman, Charles L, Sentman   +3 more
openaire   +1 more source

Alterations of NKG2D/ligands pathway in IBD

2008
Background. The mucosal immune system balances the need of co-existing with commensal flora and food antigens while responding to pathogens. Inflammatory bowel disease (IBD), comprising Crohn disease (CD) and ulcerative colitis (UC), is a chronic inflam- matory condition of the gastrointestinal tract characterized by dysregulated innate and adaptive ...
LA SCALEIA, RAFFAELLA, STOPPACCIARO, ANTONELLA, MORRONE, Stefania, OLIVA, SALVATORE, BEVIVINO G, GIAMPIETRO S, CIVITELLI, FORTUNATA, CUCCHIARA, Salvatore, SANTONI, Angela, PALMIERI, Gabriella   +9 more
openaire   +3 more sources