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NKG2D ligands: key targets of the immune response
Trends in Immunology, 2008NKG2D is an activating receptor expressed by NK and T cells. NKG2D ligands show a restricted expression in normal tissues, but they are frequently overexpressed in cancer and infected cells. The binding of NKG2D to its ligands activates NK and T cells and promotes cytotoxic lysis of the cells expressing these molecules.
Segundo, González +4 more
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NKG2D ligands as therapeutic targets.
Cancer immunity, 2014The Natural Killer Group 2D (NKG2D) receptor plays an important role in protecting the host from infections and cancer. By recognizing ligands induced on infected or tumor cells, NKG2D modulates lymphocyte activation and promotes immunity to eliminate ligand-expressing cells. Because these ligands are not widely expressed on healthy adult tissue, NKG2D
Paul, Spear +3 more
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DOWNREGULATION OF NKG2D LIGANDS BY CMV
2007The human cytomegalovirus (HCMV) is a ubiquitous pathogen causing morbidity risk in immune suppressed and immunodeficient patients.
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