Results 51 to 60 of about 18,959 (165)

The Protection Effect of Resveratrol Against Radiation-Induced Inflammatory Bowel Disease via NLRP-3 Inflammasome Repression in Mice

Dose-Response, 2020
With the extensive application of radiotherapy in various cancers, its side effects in tissues adjacent to cancers are garnering much attention. Intestines are sensitive to irradiation due to its rapid proliferation, and irradiation-induced enteric ...
Hao Sun, Hui Cai, Yue Fu, Qin Wang, Kaihua Ji, Liqing Du, Chang Xu, Lifang Tian, Ningning He, Jinhan Wang, Manman Zhang, Yang Liu, Yan Wang, Jia Li, Qiang Liu   +14 more
doaj   +1 more source

Involvement of NLRP3-inflammasome pathway in noise-induced hearing loss

Neural Regeneration Research, 2022
The inflammasome is a multiprotein oligomer in the cell cytoplasm and is part of the innate immune system. It plays a crucial role in the pathological process of noise-induced hearing loss (NIHL).
Na Sai, Yuan-Yuan Yang, Long Ma, Da Liu, Qing-Qing Jiang, Wei-Wei Guo, Wei-Ju Han   +6 more
doaj   +1 more source

Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes

European Journal of Medical Research
Abstract Objective There is a growing body of evidence indicating that pyroptosis, a programmed cell death mechanism, plays a crucial role in the exacerbation of inflammation and fibrosis in the pathogenesis of non-alcoholic fatty liver disease (NAFLD).
FengJuan Chen, YuFeng Xing, ZhiJie Chen, XiaoMan Chen, Jie Li, Si Gong, Fang Luo, QingXian Cai   +7 more
openaire   +3 more sources

Dnase1L3 Regulates Inflammasome-Dependent Cytokine Secretion

Frontiers in Immunology, 2017
Pediatric-onset systemic lupus erythematosus arises in humans and mice lacking the endonuclease Dnase1L3. When Dnase1L3 is absent, DNA from circulating apoptotic bodies is not cleared, leading to anti-DNA antibody production.
Guilan Shi, Kennady N. Abbott, Wenbo Wu, Russell D. Salter, Peter A. Keyel, Peter A. Keyel   +5 more
doaj   +1 more source

Molecular mechanisms of AMPK/YAP/NLRP3 signaling pathway affecting the occurrence and development of ankylosing spondylitis

Journal of Orthopaedic Surgery and Research, 2023
Background Investigate the AMPK (protein kinase AMP-activated catalytic subunit alpha 1)/YAP (Yes1 associated transcriptional regulator)/NLRP3 (NLR family pyrin domain containing 3) signaling pathway's role in ankylosing spondylitis (AS) development ...
Ruiyang Fu, Xiaoqing Guo, Zhongqiang Pan, Yaling Wang, Jing Xu, Lei Zhang, Jinxia Li   +6 more
doaj   +1 more source

Recent Advances in Microbiota-Associated Metabolites in Heart Failure

Biomedicines, 2023
Heart failure is a risk factor for adverse events such as sudden cardiac arrest, liver and kidney failure and death. The gut microbiota and its metabolites are directly linked to the pathogenesis of heart failure.
Sepiso K. Masenga, Joreen P. Povia, Propheria C. Lwiindi, Annet Kirabo   +3 more
doaj   +1 more source

Role of Nlrp6 and Nlrp12 in the maintenance of intestinal homeostasis [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102624/1/eji2871 ...
Couturier‐Maillard A., Couturier‐Maillard A., Inohara N.   +2 more
core   +1 more source

Domain architecture evolution of pattern-recognition receptors [PDF]

, 2010
In animals, the innate immune system is the first line of defense against invading microorganisms, and the pattern-recognition receptors (PRRs) are the key components of this system, detecting microbial invasion and initiating innate immune defenses. Two
A Bateman, A Ishii, A Marchler-Bauer, A Marchler-Bauer, A Stamatakis, AA Canutescu, Adam Godzik, AF McGettrick, AJ Robertson, AK Bjorklund, AL Hughes, AL Hughes, AP West, B Beutler, C Stein, CB Burge, CB Do, Christian M. Zmasek, D Boraschi, E Sodergren, F Leulier, F Martinon, F Ronquist, G Apic, H Oshiumi, H Qin, HA Schmidt, J Felsenstein, J Gough, J Weiner 3rd, JA Darling, JH Fritz, JH Han, JM Sasin, JP Ting, K Forslund, K Katoh, K Pawlowski, KJ Laing, L Patthy, L Sael, LA O'Neill, M Dlugosz, MJ West-Eberhard, MK Basu, N Saitou, NA Baker, NH Putnam, NH Putnam, O Gascuel, O Lespinet, PA Nuin, Q Zhang, Qing Zhang, R Desper, R Medzhitov, RR Copley, SF Altschul, SR Eddy, T Hibino, TA Binkowski, TD Kanneganti, Z Kambris   +62 more
core   +2 more sources

A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish [PDF]

, 2008
Background A large multigene family of NOD-like receptor (NLR) molecules have been described in mammals and implicated in immunity and apoptosis. Little information, however, exists concerning this gene family in non-mammalian taxa.
Hansen, John D, Laing, Kerry J, Purcell, Maureen K, Winton, James R   +3 more
core   +3 more sources

Immunomodulatory natural polysaccharide‐based nanoparticles for the treatment of neurodegenerative diseases

Ibrain, EarlyView.
Polysaccharide‐based nanoparticles offer versatile platforms for drug delivery and immune modulation in neurodegenerative diseases. This review highlights their potential in treating Alzheimer's, Parkinson's, and multiple sclerosis, focusing on targeted delivery and neuroinflammation.
Leto‐Aikaterini Tziveleka, Mariafrancesca Cascione, Paolo Pellegrino, Annalisa Bianco, Stefano Leporatti, Valeria De Matteis   +5 more
wiley   +1 more source