Results 61 to 70 of about 21,899 (194)

Relationship between sepsis-associated encephalopathy and nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome and progress of traditional Chinese medicine treatment

Chinese Journal of Contemporary Neurology and Neurosurgery
Sepsis-associated encephalopathy (SAE) is a serious complication of sepsis leading to neurological dysfunction. The pathogenesis of sepsis-associated encephalopathy is complex, and studies have proved that it is closely related to neuroinflammation ...
CHEN Yue, LIU Xue-hua
doaj   +1 more source

The Protection Effect of Resveratrol Against Radiation-Induced Inflammatory Bowel Disease via NLRP-3 Inflammasome Repression in Mice

Dose-Response, 2020
With the extensive application of radiotherapy in various cancers, its side effects in tissues adjacent to cancers are garnering much attention. Intestines are sensitive to irradiation due to its rapid proliferation, and irradiation-induced enteric ...
Hao Sun, Hui Cai, Yue Fu, Qin Wang, Kaihua Ji, Liqing Du, Chang Xu, Lifang Tian, Ningning He, Jinhan Wang, Manman Zhang, Yang Liu, Yan Wang, Jia Li, Qiang Liu   +14 more
doaj   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions

Frontiers in Immunology, 2021
Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human disorders. While NETosis is known to be regulated by peptidylarginine deiminase 4
Patrick Münzer, Patrick Münzer, Patrick Münzer, Patrick Münzer, Roberto Negro, Roberto Negro, Shoichi Fukui, Shoichi Fukui, Lucas di Meglio, Lucas di Meglio, Lucas di Meglio, Karen Aymonnier, Karen Aymonnier, Karen Aymonnier, Long Chu, Long Chu, Deya Cherpokova, Deya Cherpokova, Sarah Gutch, Sarah Gutch, Nicoletta Sorvillo, Nicoletta Sorvillo, Lai Shi, Lai Shi, Venkat Giri Magupalli, Venkat Giri Magupalli, Alexander N. R. Weber, Rüdiger E. Scharf, Rüdiger E. Scharf, Rüdiger E. Scharf, Clare M. Waterman, Clare M. Waterman, Hao Wu, Hao Wu, Denisa D. Wagner, Denisa D. Wagner, Denisa D. Wagner, Denisa D. Wagner   +37 more
doaj   +1 more source

Genetic analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol [PDF]

, 2014
The plasma levels of high-density lipoprotein cholesterol (HDL) have an inverse relationship to the risks of atherosclerosis and cardiovascular disease, and have also been associated with longevity.
Borecki, Ingrid B, Christensen, Kaare, Feitosa, Mary F, Kammerer, Candace M, Kraja, Aldi T, Lee, Joseph H, Newman, Anne B, Province, Michael A, Straka, Robert, Wojczynski, Mary K   +9 more
core   +3 more sources

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Dnase1L3 Regulates Inflammasome-Dependent Cytokine Secretion

Frontiers in Immunology, 2017
Pediatric-onset systemic lupus erythematosus arises in humans and mice lacking the endonuclease Dnase1L3. When Dnase1L3 is absent, DNA from circulating apoptotic bodies is not cleared, leading to anti-DNA antibody production.
Guilan Shi, Kennady N. Abbott, Wenbo Wu, Russell D. Salter, Peter A. Keyel, Peter A. Keyel   +5 more
doaj   +1 more source

Dehydroisohispanolone as a Promising NLRP3 Inhibitor Agent: Bioevaluation and Molecular Docking

Pharmaceuticals, 2022
Dehydroisohispanolone (DIH), is a labdane diterpene that has exhibited anti-inflammatory activity via inhibition of NF-κB activation, although its potential effects on inflammasome activation remain unexplored.
Laura González-Cofrade, Irene Cuadrado, Ángel Amesty, Ana Estévez-Braun, Beatriz de las Heras, Sonsoles Hortelano   +5 more
doaj   +1 more source

The cytoskeleton in cell-autonomous immunity: structural determinants of host defence

, 2015
Host cells use antimicrobial proteins, pathogen-restrictive compartmentalization and cell death in their defence against intracellular pathogens. Recent work has revealed that four components of the cytoskeleton — actin, microtubules, intermediate ...
A Ablasser, A Akhter, A Desai, A Fukazawa, A Stolz, AB Jaffe, AF Frade, AJ Thrasher, AL Waite, AM Keestra, AP West, AR Shenoy, Avinash R. Shenoy, B Levine, B-H Kim, BB Mishra, BT Kile, C Stevens, C Watts, CM Haglund, CS Weirich, D Chen, D Ghosal, D Parker, D Sancho, DC Rubinsztein, DJ Philpott, DL Clemens, DM Underhill, E Bi, E Caron, EL Benanti, F Caudron, F Martinon, F Randow, F Randow, F Rees, G Bonizzi, G dos Santos, G Kuhlenbaumer, G Tran Van Nhieu, H Bielig, H Herrmann, H Sridharan, H Xu, HB Yu, HS Goodridge, I Monastyrska, IM Dambuza, J Eitel, J Huang, J Jin, J Li, J Li, J Pizarro-Cerdá, J Saarikangas, J Shi, J von Moltke, J-G Zhang, JA Hagar, JA Swanson, JC Kagan, JCH Tam, JD MacMicking, JJ Bravo-Cordero, JL Dangl, JP Solomon, JR Terman, JS Hyams, JSC Arthur, JW Jones, K Aktories, K Aktories, K Dobbs, K Gotoh, KL Angus, L Blanchoin, L Kong, L Le Bourhis, LA Cameron, LA Knodler, LJF Jones, M Kokes, M Lamkanfi, M Ogawa, M Ogawa, M Pasparakis, M Rosas, M Sasai, M Yoneyama, MA Al-Zeer, MA Gavrilin, MA Gavrilin, MA Gavrilin, MA Sanjuan, MB Torchinsky, MD Welch, MJG Eldridge, ML Kim, MT Cabeen, N Ausmees, N Carayol, N Kayagaki, N Kayagaki, N Mizushima, N Ostler, N Schroeder, N Subramanian, NE Harwood, NT Snider, P Cossart, P Hanc, P Wild, P Xia, PS Manzanillo, R Goldbach-Mansky, R Mackeh, R Muñoz-Planillo, RC Wang, RE Vance, S Ahrens, S Asrat, S Iborra, S Legrand-Poels, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Park, S Savic, S Zelenay, SA Schattgen, SCO Reed, Serge Mostowy, SL Sandiford, SM Man, T Fernandes-Alnemri, T Kawai, T Misawa, T Strowig, T Tamura, TA Kufer, TD Pollard, TLM Thurston, U Golebiewska, V Deretic, VAK Rathinam, VAK Rathinam, W-D Hardt, WA McEwan, WM Schneider, X Cai, Y Aachoui, Y Aachoui, Y Kumar, Y Ma, Y Song, Y Tanaka-Takiguchi, Y Yoshikawa, Y Zhao, Y-W Huang, YT Zheng   +165 more
core   +1 more source

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens [PDF]

, 2012
Members of the intracellular nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family contribute to immune responses through activation of nuclear factor-kappa B (NF-kappa B), type I interferon and inflammasome signalling(1).
C van Ooij, DA Portnoy, E Elinav, E Scallan, EM Creagh, GY Chen, J Henao-Mejia, JM Grenier, John Bertin, John R. Lukens, K Hybiske, K Meixenberger, KS Kobayashi, L Franchi, M Lara-Tejero, MH Zaki, MM Stevenson, Mohamed Lamkanfi, MR Waterfield, NV Serbina, P Broz, Paras K. Anand, Peter Vogel, PK Anand, R. K. Subbarao Malireddi, S Normand, SC Corr, SE Girardin, TD Kanneganti, TD Kanneganti, Thirumala-Devi Kanneganti, V Pétrilli   +31 more
core   +1 more source