Results 61 to 70 of about 18,959 (165)

Baicalin Inhibits NOD-Like Receptor Family, Pyrin Containing Domain 3 Inflammasome Activation in Murine Macrophages by Augmenting Protein Kinase A Signaling

Frontiers in Immunology, 2017
The flavonoid baicalin has been reported to possess potent anti-inflammatory activities by suppressing inflammatory signaling pathways. However, whether baicalin can suppress the activation of NOD-like receptor (NLR) family, pyrin containing domain 3 ...
Chen-Guang Li, Liang Yan, Feng-Yi Mai, Zi-Jian Shi, Li-Hui Xu, Yan-Yun Jing, Qing-Bing Zha, Dong-Yun Ouyang, Xian-Hui He   +8 more
doaj   +1 more source

Is the inflammasome a potential therapeutic target in renal disease? [PDF]

, 2014
The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine production in response to infection and tissue injury. Pattern recognition receptors that are either membrane bound or cytoplasmic trigger inflammasome assembly. These
A Chen, A Covic, A Dorfleutner, A Fukami, A Granfeldt, A MacKenzie, A So, A Vilaysane, AA Shigeoka, AH Bani-Hani, AJ Puren, AM Karkar, AM Karkar, AN Economides, AS Yazdi, BA VanderBrink, BJ Pereira, C Dostert, C Hammerberg, CA Dinarello, CA Dinarello, CA Dinarello, CA Dinarello, CJ Chen, CL Edelstein, CL Myers, Clare M Turner, CM Turner, CM Turner, CM Yang, CR Parikh, D Choubey, D Ferrari, D Ferrari, D Nordstrom, D Sola-Villa, DG Perregaux, E Homsi, EA Kurt-Jones, EA Miao, EC Keystone, ED Siew, EM Kofoed, F Bauernfeind, F Knauf, F Turkmen, FG Bauernfeind, Frederick WK Tam, FW Tam, FW Tam, G Dell’Antonio, G Dell’Antonio, G Kaplanski, G Nuki, G Ren, GY Chen, H Harada, H Kohka, H Ranjbaran, H Saiga, H von Bernuth, H Wu, H Yamagishi, H Zhang, HJ Lachmann, HM Hoffman, HU Schorlemmer, HY Lan, I Jalilian, IC Allen, J Lichtnekert, J Wang, JC Morel, JL Levinsohn, JM Bruey, JM Kahlenberg, JR Timoshanko, K Furuichi, K Kersse, K Kinoshita, K Matsumoto, K Rusai, K Takeda, K Wareham, KL Williams, KM Sumpter, LK Parvathenani, M Hacham, M Haq, M Lech, M Mizobuchi, M Shiohara, M Sugiyama, M Takeuchi, M Tomura, MD Wewers, Mervyn Singer, MP Bevilacqua, N Arulkumaran, N Arulkumaran, N Kolliputi, N Ueno, NA Thornberry, NB Bryan, NB Bryan, Nishkantha Arulkumaran, O Gross, O Hertting, O Vonend, R Alten, R Goldbach-Mansky, R Imamura, RG Goncalves, Robert J Unwin, S Cornelis, S Deplano, S Gangemi, S Gauer, SC Whitman, SL Fernando, SL Fink, SR Ali, SR Mulay, SR Taylor, SR Taylor, SS Iyer, T Bergsbaken, T Bergsbaken, T Dao, T Fujita, T Porazko, TL Roberts, U Kavita, V Hurgin, V Pascual, W Wang, X Wang, Y Chung, Y le Meur, Y Liu, Y Zhao, Z Mallat, Z Ye   +142 more
core   +1 more source

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Med Research, EarlyView.
ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li, Yuxuan Wan, Alan Jiao, Ke Jiang, Gaoyuan Cui, Jinxin Tang, Simin Yu, Zhengang Hu, Songfeng Zhao, Zhenjie Yi, Lifu Long, Yang Yang, Xuehao Cui, Chunrun Qu   +13 more
wiley   +1 more source

NEK7-Mediated Activation of NLRP3 Inflammasome Is Coordinated by Potassium Efflux/Syk/JNK Signaling During Staphylococcus aureus Infection

Frontiers in Immunology, 2021
Staphylococcus aureus (S. aureus) is a foodborne pathogen that causes severe diseases, such as endocarditis, sepsis, and bacteremia. As an important component of innate immune system, the NLR family pyrin domain-containing 3 (NLRP3) inflammasome plays a ...
Ruiqing Liu, Yashan Liu, Chang Liu, Aijiao Gao, Lin Wang, Huixin Tang, Qiang Wu, Xia Wang, Derun Tian, Zhi Qi, Yanna Shen, Yanna Shen   +11 more
doaj   +1 more source

Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment

Molecular Nutrition &Food Research, EarlyView.
Effect of Natural Polyphenols on Breast Cancer proliferation and progression. ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and cancer treatments in the past decade; however, the complexity and heterogeneity of certain breast cancer subtypes often lead to ...
Marzia Sichetti, Martina Giuseffi, Eugenia Giglio, Graziella Marino, Marisabel Mecca   +4 more
wiley   +1 more source

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex. [PDF]

, 2014
Pathogen recognition by nucleotide-binding oligomerization domain-like receptor (NLR) results in the formation of a macromolecular protein complex (inflammasome) that drives protective inflammatory responses in the host.
Bryant, Clare E, Cicuta, Pietro, Cox, Susan, Glück, Ivo M, Hopkins, Lee J, Man, Si Ming, Monie, Tom P, Nugent, Eileen, Tourlomousis, Panagiotis, Wright, John A   +9 more
core   +2 more sources

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy

British Journal of Pharmacology, EarlyView.
Abstract Contemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear.
Zihan Qu, Jiajun Dong, Zhong‐Yin Zhang
wiley   +1 more source

The cytoskeleton in cell-autonomous immunity: structural determinants of host defence

, 2015
Host cells use antimicrobial proteins, pathogen-restrictive compartmentalization and cell death in their defence against intracellular pathogens. Recent work has revealed that four components of the cytoskeleton — actin, microtubules, intermediate ...
A Ablasser, A Akhter, A Desai, A Fukazawa, A Stolz, AB Jaffe, AF Frade, AJ Thrasher, AL Waite, AM Keestra, AP West, AR Shenoy, Avinash R. Shenoy, B Levine, B-H Kim, BB Mishra, BT Kile, C Stevens, C Watts, CM Haglund, CS Weirich, D Chen, D Ghosal, D Parker, D Sancho, DC Rubinsztein, DJ Philpott, DL Clemens, DM Underhill, E Bi, E Caron, EL Benanti, F Caudron, F Martinon, F Randow, F Randow, F Rees, G Bonizzi, G dos Santos, G Kuhlenbaumer, G Tran Van Nhieu, H Bielig, H Herrmann, H Sridharan, H Xu, HB Yu, HS Goodridge, I Monastyrska, IM Dambuza, J Eitel, J Huang, J Jin, J Li, J Li, J Pizarro-Cerdá, J Saarikangas, J Shi, J von Moltke, J-G Zhang, JA Hagar, JA Swanson, JC Kagan, JCH Tam, JD MacMicking, JJ Bravo-Cordero, JL Dangl, JP Solomon, JR Terman, JS Hyams, JSC Arthur, JW Jones, K Aktories, K Aktories, K Dobbs, K Gotoh, KL Angus, L Blanchoin, L Kong, L Le Bourhis, LA Cameron, LA Knodler, LJF Jones, M Kokes, M Lamkanfi, M Ogawa, M Ogawa, M Pasparakis, M Rosas, M Sasai, M Yoneyama, MA Al-Zeer, MA Gavrilin, MA Gavrilin, MA Gavrilin, MA Sanjuan, MB Torchinsky, MD Welch, MJG Eldridge, ML Kim, MT Cabeen, N Ausmees, N Carayol, N Kayagaki, N Kayagaki, N Mizushima, N Ostler, N Schroeder, N Subramanian, NE Harwood, NT Snider, P Cossart, P Hanc, P Wild, P Xia, PS Manzanillo, R Goldbach-Mansky, R Mackeh, R Muñoz-Planillo, RC Wang, RE Vance, S Ahrens, S Asrat, S Iborra, S Legrand-Poels, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Park, S Savic, S Zelenay, SA Schattgen, SCO Reed, Serge Mostowy, SL Sandiford, SM Man, T Fernandes-Alnemri, T Kawai, T Misawa, T Strowig, T Tamura, TA Kufer, TD Pollard, TLM Thurston, U Golebiewska, V Deretic, VAK Rathinam, VAK Rathinam, W-D Hardt, WA McEwan, WM Schneider, X Cai, Y Aachoui, Y Aachoui, Y Kumar, Y Ma, Y Song, Y Tanaka-Takiguchi, Y Yoshikawa, Y Zhao, Y-W Huang, YT Zheng   +165 more
core   +1 more source

Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways. [PDF]

, 2015
Caspase-8 is an apical component of cell death pathways. Activated caspase-8 can drive classical caspase-dependent apoptosis and actively inhibits cell death mediated by RIPK3-driven necroptosis.
Bryant, Clare E, Monie, Tom P
core   +2 more sources

Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63‐specific ubiquitination

British Journal of Pharmacology, EarlyView.
▪ Background and Purpose NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product with multiple anti‐inflammatory activities, but a narrow therapeutic window ...
Mo‐Yu Ding, Chengqing Ning, Shao‐Ru Chen, Hao‐Ran Yin, Jing Xu, Ying Wang   +5 more
wiley   +1 more source