Results 71 to 80 of about 18,959 (165)

Suppression of ZBP1-mediated NLRP3 inflammasome by the tegument protein VP22 facilitates pseudorabies virus infection

mBio
The interaction between Z-DNA binding protein 1 (ZBP1) and the NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been uncovered in several viral infections.
Zicheng Ma, Depeng Liu, Wandi Cao, Lei Guo, Kesen Liu, Juan Bai, Xingyi Li, Ping Jiang, Xing Liu   +8 more
doaj   +1 more source

NLRP3 inflammasome activation in neutrophils directs early inflammatory response in murine peritonitis

Scientific Reports, 2022
NLR family pyrin domain containing 3 (NLRP3) inflammasome mediates caspase-1-dependent processing of inflammatory cytokines such as IL-1β, an essential endothelial activator, and contributes to the pathology of inflammatory diseases. To evaluate the role
Saeko Fukui, Shoichi Fukui, Stijn Van Bruggen, Lai Shi, Casey E. Sheehy, Long Chu, Denisa D. Wagner   +6 more
doaj   +1 more source

NOD-like receptors and inflammation [PDF]

, 2008
The nucleotide-binding and oligomerization domain, leucine-rich repeat (also known as NOD-like receptors, both abbreviated to NLR) family of intracellular pathogen recognition receptors are increasingly being recognized to play a pivotal role in the ...
Mathews, Rebeccah J, McDermott, Michael F, Sprakes, Michael B   +2 more
core   +3 more sources

Two Novel Protein‐Truncating Variants in NLRP2 and Their Functional Impacts on the Subcortical Maternal Complex

Clinical Genetics, EarlyView.
Two deleterious protein‐truncating NLRP2 variants were identified in a patient with female infertility, four early miscarriages, and one failed attempt of intracytoplasmic sperm injection. The variants mediate mRNA decay and alter NLRP2 structure and interactions with other members of the SCMC.
Zeynep Yalcin, Zheng Gao, Ibrahim M. Abdelrazek, Eric Bareke, Jacek Majewski, Ebtesam Abdalla, Seang‐Lin Tan, Lei Li, Rima Slim   +8 more
wiley   +1 more source

KYNA Ameliorates Hepatic Ischemia–Reperfusion Injury by Activating the Hippo Signalling Pathway via FTO‐Dependent m6A Demethylation of LATS1

Cell Proliferation, EarlyView.
Our study elucidates the cellular and molecular mechanisms underlying KYNA's protective effects against HIRI. It emphasises that KYNA modulates the methylation status of the Hippo signalling pathway through the activation of AHR, thereby mitigating damage by promoting LATS1 degradation and facilitating the nuclear translocation of YAP. ABSTRACT Hepatic
Wenjie Zheng, Xiaowen Wang, Haoqi Chen, Kaiming He, Xijing Yan, Yuan Zhang, Yang Yang, Peng Zhang, Wenfeng Zhu, Shuguang Zhu, Hua Li   +10 more
wiley   +1 more source

Inflammasome biology, molecular pathology and therapeutic implications [PDF]

, 2018
Inflammasomes are intracellular multiprotein signaling complexes, mainly present in myeloid cells. They commonly assemble around a cytoplasmic receptor of the nucleotide-binding leucine-rich repeat containing receptor (NLR) family, although other ...
Amselem, Serge, Assrawi, Eman, Awad, Fawaz, Georgin-Lavialle, Sophie, Giurgea, Irina, Grateau, Gilles, Jumeau, Claire, Karabina, Sonia-Athina, Louvrier, Camille   +8 more
core   +2 more sources

Macrophages and autophagy: partners in crime

The FEBS Journal, EarlyView.
Autophagy is a key regulator of macrophage function, influencing critical processes like polarization, cytokine secretion, and phagocytosis. Its impact on macrophage behavior varies across different tissues and disease contexts, where it can either promote protective responses or contribute to detrimental outcomes, depending on the physiological or ...
Alessandra Vitaliti, Alessio Reggio, Alessandro Palma   +2 more
wiley   +1 more source

Francisella Recognition by Inflammasomes: Differences between Mice and Men [PDF]

, 2011
Pathogen recognition by intracellular sensors involves the assembly of a caspase-1 activation machine termed the inflammasome. Intracellular pathogens like Francisella that gain access to the cytosolic detection systems are useful tools to uncover the ...
Gavrilin, Mikhail A., Wewers, Mark D.
core   +3 more sources

The Landscape of SPP1+ Macrophages Across Tissues and Diseases: A Comprehensive Review

Immunology, EarlyView.
SPP1+ macrophages represent a conserved, disease‐associated population present across cancerous and non‐cancerous conditions, involved in immunosuppression, fibrosis, lipid metabolism, phagocytosis, and other cellular processes. This review highlights their shared molecular programmes across tissues, their interactions with stromal and immune cells ...
Alessandro Palma
wiley   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source