Results 71 to 80 of about 21,899 (194)

Involvement of NLRP3-inflammasome pathway in noise-induced hearing loss

Neural Regeneration Research, 2022
The inflammasome is a multiprotein oligomer in the cell cytoplasm and is part of the innate immune system. It plays a crucial role in the pathological process of noise-induced hearing loss (NIHL).
Na Sai, Yuan-Yuan Yang, Long Ma, Da Liu, Qing-Qing Jiang, Wei-Wei Guo, Wei-Ju Han   +6 more
doaj   +1 more source

Recent Advances in Microbiota-Associated Metabolites in Heart Failure

Biomedicines, 2023
Heart failure is a risk factor for adverse events such as sudden cardiac arrest, liver and kidney failure and death. The gut microbiota and its metabolites are directly linked to the pathogenesis of heart failure.
Sepiso K. Masenga, Joreen P. Povia, Propheria C. Lwiindi, Annet Kirabo   +3 more
doaj   +1 more source

CD90+ Stromal Cells are Non-Professional Innate Immune Effectors of the Human Colonic Mucosa [PDF]

, 2013
Immune responses at the intestinal mucosa must allow for host protection whilst simultaneously avoiding inappropriate inflammation. Although much work has focused on the innate immune functionality of hematopoietic immune cells, non-hematopoietic cell ...
Alice eMayer, Alison eSimmons, Alison eSimmons, Benjamin M J Owens, David eWalcott, Mei-Yi eSun, Michael eDudek, Philip eAllan, Tessa A M Steevels   +8 more
core   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Molecular mechanisms of AMPK/YAP/NLRP3 signaling pathway affecting the occurrence and development of ankylosing spondylitis

Journal of Orthopaedic Surgery and Research, 2023
Background Investigate the AMPK (protein kinase AMP-activated catalytic subunit alpha 1)/YAP (Yes1 associated transcriptional regulator)/NLRP3 (NLR family pyrin domain containing 3) signaling pathway's role in ankylosing spondylitis (AS) development ...
Ruiyang Fu, Xiaoqing Guo, Zhongqiang Pan, Yaling Wang, Jing Xu, Lei Zhang, Jinxia Li   +6 more
doaj   +1 more source

A molecular model of the full-length human NOD-like receptor family CARD domain containing 5 (NLRC5) protein [PDF]

, 2013
BACKGROUND: Pattern recognition receptors of the immune system have key roles in the regulation of pathways after the recognition of microbial- and danger-associated molecular patterns in vertebrates.
Bagossi, Péter, Benkő, Szilvia, Mótyán, János, Tőzsér, József   +3 more
core   +1 more source

Involvement of the miR‐128‐3p/KDM3A/NLRP3 Axis in High Glucose‐Induced Inflammatory Injury in Retinal Endothelial Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study explores the regulatory mechanism of the miR‐128‐3p in diabetic retinopathy (DR)‐associated inflammatory injury. A cellular model of DR was established by inducing immortalized human retinal endothelial cells (IM‐HRECs) with high‐glucose (HG).
Wei‐Ming Wen, Jian‐Bo Feng, Yin‐Sheng Cai, Nan Lin, Fei Lv, Zhu‐Sheng Guo   +5 more
wiley   +1 more source

Suppression of ZBP1-mediated NLRP3 inflammasome by the tegument protein VP22 facilitates pseudorabies virus infection

mBio
The interaction between Z-DNA binding protein 1 (ZBP1) and the NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been uncovered in several viral infections.
Zicheng Ma, Depeng Liu, Wandi Cao, Lei Guo, Kesen Liu, Juan Bai, Xingyi Li, Ping Jiang, Xing Liu   +8 more
doaj   +1 more source

Sacubitril/Valsartan Ameliorates Inflammation and Oxidative Stress in Hypertensive Heart Disease by Upregulating CAMKK2 Protein and Modulating the AMPK/AKT/GSK‐3β Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sacubitril/valsartan (Sac/Val) has emerged as an effective compound with myocardium‐protective functions in experimental and clinical trials for heart failure. This study investigated the function of Sac/Val in hypertensive heart disease (HHD) and explored the underlying mechanism.
Yan‐Jun Yang, Jiu‐Sheng Li
wiley   +1 more source

PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner [PDF]

, 2017
A variant within the gene locus encoding PTPN22 (protein tyrosine phosphatase, non-receptor type 22) emerged as an important risk factor for auto-inflammatory disorders, including rheumatoid arthritis, systemic lupus erythematosus and type 1 diabetes ...
Chan, Andrew C, Dai, Xuezhi, Gottier, Claudia, Lang, Silvia, Rawlings, David J, Rogler, Gerhard, Scharl, Michael, Spalinger, Marianne R   +7 more
core   +2 more sources