Results 81 to 90 of about 18,959 (165)

The multifaceted roles of ketones in physiology

Experimental Physiology, EarlyView.
Abstract The production of ketones, referred to as ketogenesis, plays an essential role in maintaining energy homeostasis during prolonged fasting/starvation, which primarily stems from its ability to serve as a fuel source to support neuronal ATP production, thereby limiting muscle wasting. Over the years, the field has come to appreciate that ketones
Seyed Amirhossein Tabatabaei Dakhili, Kunyan Yang, Magnus J. Stenlund, John R. Ussher   +3 more
wiley   +1 more source

Expression of urotensin II is positively correlated with pyroptosis-related molecules in patients with severe preeclampsia

Clinical and Experimental Hypertension, 2021
Purpose: We studied the expression of urotensin II (UII) and its relationships with markers of pyroptosis in preeclampsia. Methods: 48 pregnant subjects were recruited consisting of 28 severe preeclampsia pregnancies (SPE) and 20 healthy pregnancies.
Ya-Jing Pan, Meng-Ze Zhang, Lin-Hui He, Jin Feng, Ai-Hua Zhang   +4 more
doaj   +1 more source

Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms

Journal of Pineal Research, Volume 77, Issue 4, July 2025.
ABSTRACT Melatonin is a versatile neurohormone with diverse molecular functions, including sleep regulation, inflammation reduction, antioxidant activity, immune modulation, and anticancer properties. In bone metabolism, it promotes osteoblast formation, inhibits osteoclast activity, and synchronizes skeletal tissue rhythms to support bone health.
Ko‐Hsiu Lu, Yi‐Hsien Hsieh, Renn‐Chia Lin, Meng‐Ying Tsai, Shun‐Fa Yang   +4 more
wiley   +1 more source

Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease

Biomedical Journal, 2023
Inflammation plays an important role in the pathophysiology of cardiometabolic diseases. Sterile inflammation, a non-infectious and damage-associated molecular pattern (DAMP)-induced innate response, is now well-established to be closely associated with ...
Sungji Cho, Fan Ying, Gary Sweeney
doaj  

Physiology and Pathology of Autoinflammation: NOD like Receptors in Autoinflammation and Autoimmunity [PDF]

, 2017
Immune regulation is an essential feature of immune responses. The failure of such regulation results in allergic reactions and debilitating autoimmune diseases that can be fatal.
Ciraci, Ceren
core   +2 more sources

Ferulic acid: extraction, estimation, bioactivity and applications for human health and food

Journal of the Science of Food and Agriculture, Volume 105, Issue 8, Page 4168-4177, June 2025.
Abstract Ferulic acid ((E)‐3‐(4‐hydroxy‐3‐methoxy‐phenyl) prop‐2‐enoic acid) is a derivative of caffeic acid found in most plants. This abundant phenolic compound exhibits significant antioxidant capacity and a broad spectrum of therapeutic effects, including anti‐inflammatory, antimicrobial, anticancer, antidiabetic, cardiovascular and neuroprotective
Mukul Kumar, Deepika Kaushik, Shubham Shubham, Ashwani Kumar, Vishal Kumar, Emel Oz, Charles Brennan, Maomao Zeng, Charalampos Proestos, Kenan Çadırcı, Muharrem Bayrak, Tahra Elobeid, Sercan Karav, Fatih Oz   +13 more
wiley   +1 more source

SOAT1 Activates NLRP3 Inflammasome to Promote Cancer‐Related Lymphangiogenesis and Metastasis via IL‐1β/IL‐1R‐1 Axis in Oral Squamous Cell Carcinoma

Molecular Carcinogenesis, Volume 64, Issue 6, Page 1039-1056, June 2025.
ABSTRACT Oral squamous cell carcinoma (OSCC) is a prevalent type of cancer in the head and neck region, significantly impacting patient survival rates and quality of life. Lymph node (LN) metastasis is a lead contributor to the poor prognosis associated with OSCC.
Chengzhi Zhao, Yuhao Wang, Zhishen Jiang, Shengzhao Guo, Liru Hu, Jian Pan, Fan Dan   +6 more
wiley   +1 more source

USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis

Frontiers in Immunology
Duodenogastric reflux (DGR) has been linked to the onset of gastric cancer (GC), although the precise mechanism is yet obscure. Herein, we aimed to investigate how refluxed bile acids (BAs) and macrophages are involved in gastric carcinogenesis.
Chenye Zhao, Mingchao Mu, Xiaopeng Li, Zepeng Dong, Jiahao Wang, Chengzhi Yao, Jianbao Zheng, Xuejun Sun, Junhui Yu   +8 more
doaj   +1 more source

Recent evolution of the NF-κB and inflammasome regulating protein POP2 in primates [PDF]

, 2011
Background Pyrin-only protein 2 (POP2) is a small human protein comprised solely of a pyrin domain that inhibits NF-κB p65/RelA and blocks the formation of functional IL-1β processing inflammasomes.
A Dorfleutner, A Dorfleutner, C Stehlik, CM Wang, DE Cressman, DG Higgins, DM Church, EM Creagh, EW Humke, F Bedoya, F Macaluso, G Chen, GH Westerveld, HE Barksby, HG Parker, J Qian, J Rintahaka, JA Harton, JH Fritz, JM Bruey, Jonathan A Harton, JP Ting, JP Ting, K Tamura, K Tamura, LD Church, M Goodman, M Horikawa, M Lamkanfi, Maninjay K Atianand, O Podlaha, RC Edgar, S Jha, S Kumar, S Murdoch, S Ponsuksili, S Stojanov, SH Lee, T Kawai, T Kinoshita, Travis Fuchs, ZB Tong   +41 more
core   +3 more sources

Additional file 2 of Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes

Additional file 2. The sequences of siRNAs and the map of the pcDNA3.1 vector.
Chen, FengJuan, Xing, YuFeng, Chen, ZhiJie, Chen, XiaoMan, Li, Jie, Gong, Si, Luo, Fang, Cai, QingXian   +7 more
openaire   +1 more source