Results 81 to 90 of about 21,761 (205)

Suppression of ZBP1-mediated NLRP3 inflammasome by the tegument protein VP22 facilitates pseudorabies virus infection

mBio
The interaction between Z-DNA binding protein 1 (ZBP1) and the NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been uncovered in several viral infections.
Zicheng Ma, Depeng Liu, Wandi Cao, Lei Guo, Kesen Liu, Juan Bai, Xingyi Li, Ping Jiang, Xing Liu   +8 more
doaj   +1 more source

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector? [PDF]

, 2015
Significance: Inflammasomes are multiprotein complexes localized within the cytoplasm of the cell that are responsible for the maturation of proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18, and the activation of a highly inflammatory ...
Abais, Justine M., Boini, Krishna M., Li, Pin-Lan, Xia, Min, Zhang, Yang   +4 more
core   +2 more sources

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Baicalin Inhibits NOD-Like Receptor Family, Pyrin Containing Domain 3 Inflammasome Activation in Murine Macrophages by Augmenting Protein Kinase A Signaling

Frontiers in Immunology, 2017
The flavonoid baicalin has been reported to possess potent anti-inflammatory activities by suppressing inflammatory signaling pathways. However, whether baicalin can suppress the activation of NOD-like receptor (NLR) family, pyrin containing domain 3 ...
Chen-Guang Li, Liang Yan, Feng-Yi Mai, Zi-Jian Shi, Li-Hui Xu, Yan-Yun Jing, Qing-Bing Zha, Dong-Yun Ouyang, Xian-Hui He   +8 more
doaj   +1 more source

PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner [PDF]

, 2017
A variant within the gene locus encoding PTPN22 (protein tyrosine phosphatase, non-receptor type 22) emerged as an important risk factor for auto-inflammatory disorders, including rheumatoid arthritis, systemic lupus erythematosus and type 1 diabetes ...
Chan, Andrew C, Dai, Xuezhi, Gottier, Claudia, Lang, Silvia, Rawlings, David J, Rogler, Gerhard, Scharl, Michael, Spalinger, Marianne R   +7 more
core   +2 more sources

Involvement of the miR‐128‐3p/KDM3A/NLRP3 Axis in High Glucose‐Induced Inflammatory Injury in Retinal Endothelial Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study explores the regulatory mechanism of the miR‐128‐3p in diabetic retinopathy (DR)‐associated inflammatory injury. A cellular model of DR was established by inducing immortalized human retinal endothelial cells (IM‐HRECs) with high‐glucose (HG).
Wei‐Ming Wen, Jian‐Bo Feng, Yin‐Sheng Cai, Nan Lin, Fei Lv, Zhu‐Sheng Guo   +5 more
wiley   +1 more source

The Inflammatory Response to Enterotoxigenic E. coli and Probiotic E. faecium in a Coculture Model of Porcine Intestinal Epithelial and Dendritic Cells [PDF]

, 2018
The gut epithelium constitutes an interface between the intestinal contents and the underlying gut-associated lymphoid tissue (GALT) including dendritic cells (DC).
Aschenbach, Jörg R., Ebner, Friederike, Lodemann, Ulrike, Loss, Henriette, Tedin, Karsten   +4 more
core   +1 more source

Sacubitril/Valsartan Ameliorates Inflammation and Oxidative Stress in Hypertensive Heart Disease by Upregulating CAMKK2 Protein and Modulating the AMPK/AKT/GSK‐3β Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sacubitril/valsartan (Sac/Val) has emerged as an effective compound with myocardium‐protective functions in experimental and clinical trials for heart failure. This study investigated the function of Sac/Val in hypertensive heart disease (HHD) and explored the underlying mechanism.
Yan‐Jun Yang, Jiu‐Sheng Li
wiley   +1 more source

Pattern recognition receptors in antifungal immunity [PDF]

, 2014
We thank the Wellcome Trust for funding this study.Peer reviewedPublisher ...
Brown, Gordon D, Hardison, Sarah E, Plato, Anthony   +2 more
core   +2 more sources

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source