Results 121 to 130 of about 131,202 (338)

Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease

Journal of Inflammation Research, 2021
Nan Ji,1,2,* Zhongwen Qi,1,* Yueyao Wang,1 Xiaoya Yang,1 Zhipeng Yan,1 Meng Li,1 Qihui Ge,1 Junping Zhang1 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300183, People’s Republic of China; 2National ...
Ji N, Qi Z, Wang Y, Yang X, Yan Z, Li M, Ge Q, Zhang J   +7 more
doaj  

Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Advanced Science, EarlyView.
This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song, Xiangxu Wang, Luqing Ha, Lamei Hu, Shuyuan Mei, Yue Liang, Yujie Zhao, Xingyin Yang, Qingyu Zhang, Yuanzhang Zhou, Jianhua Ding, Yan Liu, Qigang Zhou, Feng Han, Gang Hu, Ming Lu   +15 more
wiley   +1 more source

Association of a NLRP3 rs10754558 Polymorphism with the Development of Chronic Helicobacter pylori Infection in South Indian Tamils

Journal of Pure and Applied Microbiology
The increased prevalence of Helicobacter pylori infection and inadequate genetic research on the same, demands a genetic study among Tamil population of South India to unravel the association of NLRP3 (NLR family pyrin domain containing 3) variants with ...
Abirami Rajendran, Vignesh Nagarajan, Premkumar Karunakaran, Shameli Jeevamani, Megala Jayaraman   +4 more
doaj   +1 more source

Inflammasome as an Effective Platform for Fibrosis Therapy

Journal of Inflammation Research, 2021
Ting-Ting Chen,* Feng Xiao,* Nan Li, Shan Shan, Meng Qi, Zi-Ying Wang, Sheng-Nan Zhang, Wei Wei, Wu-Yi Sun Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui
Chen TT, Xiao F, Li N, Shan S, Qi M, Wang ZY, Zhang SN, Wei W, Sun WY   +8 more
doaj  

Targeting Hyperglycemic Bone Pre‐Metastatic Niche for Breast Cancer Bone Metastasis Therapy

Advanced Science, EarlyView.
This study reveals that breast cancer creates a hyperglycemic pre‐metastatic niche in bone prior to colonization and amplifies glucose metabolism post‐metastasis. To target this mechanism, a biomimetic enzyme‐engineered nanoplatform that disrupts tumor glycolytic pathways, proposing a therapeutic strategy to inhibit breast cancer bone metastasis by ...
Jianxin Ye, Peng Hu, Rui Zhang, Lei Zhou, Zonghua Luo, Yanan Chen, Shengzhe Ruan, Mengyi Zhu, Huaze Ding, Yike Qian, Yan Xing, Tong Meng, Changping Wang, Dianwen Song   +13 more
wiley   +1 more source

Role of Pyroptosis in Diabetes and Its Therapeutic Implications

Journal of Inflammation Research, 2021
Abdullah Al Mamun,1 Yanqing Wu,2 Fatema Nasrin,3,4 Afroza Akter,5 Masuma Afrin Taniya,6 Fahad Munir,7 Chang Jia,8 Jian Xiao1 1Department of Hand Surgery and Peripheral Neurosurgery, The First Affiliated Hospital and School of Pharmaceutical Sciences ...
Al Mamun A, Wu Y, Nasrin F, Akter A, Taniya MA, Munir F, Jia C, Xiao J   +7 more
doaj  

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Mangiferin Mitigates Lipopolysaccharide-Induced Lung Injury by Inhibiting NLRP3 Inflammasome Activation

Journal of Inflammation Research, 2021
Ning Li,* Rui Xiong,* Ruyuan He, Bohao Liu, Bo Wang, Qing Geng Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bo Wang ...
Li N, Xiong R, He R, Liu B, Wang B, Geng Q   +5 more
doaj  

UTX Responds to Nanotopography to Suppress Macrophage Inflammatory Response by Remodeling H3K27me3 Modification

Advanced Science, EarlyView.
Compared with those on the pTi surface, macrophages on the TNTs surface present reduced myosin II contractility, which facilitates the nuclear translocation of the UTX. This reduction decreases the enrichment of the repressive H3K27me3 histone modification at the Abca1 gene locus, which promotes the transcription and protein expression of ABCA1 ...
Hengji Jia, He Zhang, Dingqiang Mo, Bo Xie, Hongdou Qiao, Tao Chen, Haoyue Song, Xinxin Xu, Sheng Yang   +8 more
wiley   +1 more source

cGAS/STING/NLRP3 Signaling Pathway-Mediated Pyroptosis in Hypertrophic Cardiomyopathy Radiotherapy

Frontiers in Bioscience-Landmark
Background: Radiotherapy is a commonly employed treatment modality for cancer; however, its radiobiological effects in hypertrophic cardiomyopathy (HCM) remain unclear.
Huiyang Li, Xin Wang, Xinping Luo, Haiming Shi, Jian Li   +4 more
doaj   +1 more source