Results 11 to 20 of about 100,759 (296)
Nanoemulsions for “Nose-to-Brain” Drug Delivery [PDF]
Pharmaceutics, 2019 The blood⁻brain barrier (BBB) plays a fundamental role in protecting the brain from toxic substances and therefore also controls and restricts the entry of therapeutic agents. The nasal administration of drugs using the nose-to-brain pathway allows
Maria Cristina Bonferoni +6 more
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Microemulsion-Based Media in Nose-to-Brain Drug Delivery [PDF]
Pharmaceutics, 2021 Nose-to-brain drug delivery has recently attracted enormous attention as an alternative to other delivery routes, including the most popular oral one.
Anna Froelich +4 more
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EncyclopediaNose-to-brain drug delivery is an innovative approach that leverages the unique anatomical pathways connecting the nasal cavity to the brain, including the olfactory and trigeminal nerve routes.
Linh Thi-Thao Nguyen, Van-An Duong
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Pharmaceutics, 2022 Nose-to-brain drug delivery has been of great interest for the treatment of many central nervous system (CNS) diseases and psychiatric disorders over past decades.
Thi-Thao-Linh Nguyen, Han-Joo Maeng
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Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting
Pharmaceutics, 2018 In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating applications, directly targeting the central nervous system, bypassing the blood brain barrier.
Fabio Sonvico +7 more
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Chitosan-Based Nanocarriers for Nose to Brain Delivery [PDF]
Applied Sciences, 2019 In the treatment of brain diseases, most potent drugs that have been developed exhibit poor therapeutic outcomes resulting from the inability of a therapeutic amount of the drug to reach the brain.
Blessing Atim Aderibigbe, Tobeka Naki
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Nose-to-brain drug delivery: from bench to bedside
Translational NeurodegenerationThere is increasing interest in nose-to-brain delivery as an innovative drug delivery strategy for neurodegenerative disorders such as Parkinson’s or Alzheimer’s disease.
Isabell Drath +2 more
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Engineered commensals for targeted nose-to-brain drug delivery
CellShen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic molecules. When engineered to secrete appetite-regulating hormones, intranasal delivery of L. plantarum alleviates obesity-related symptoms in a mouse model.
Haosheng Shen +13 more
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Formulation Strategies to Improve Nose-to-Brain Delivery of Donepezil [PDF]
Pharmaceutics, 2019 Donepezil (DPZ) is widely used in the treatment of Alzheimer’s disease in tablet form for oral administration. The pharmacological efficacy of this drug can be enhanced by the use of intranasal administration because this route makes bypassing the ...
Lupe Carolina Espinoza +6 more
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The Journal of Pharmacology and Experimental Therapeutics, 2019 The global prevalence of neurologic disorders is rising, and yet we are still unable to deliver most drug molecules, in therapeutic quantities, to the brain. The blood brain barrier consists of a tight layer of endothelial cells surrounded by astrocyte foot processes, and these anatomic features constitute a significant barrier to drug transport from ...
Uchegbu, I +4 more
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