Results 21 to 30 of about 100,759 (296)
Focused ultrasound-mediated intranasal brain drug delivery technique (FUSIN)
MethodsX, 2021 The blood-brain barrier (BBB) is the major obstacle for brain drug delivery and limits the treatment options for central nervous system diseases. To circumvent the BBB, we introduce focused ultrasound-mediated intranasal brain drug delivery (FUSIN ...
Dezhuang Ye, Hong Chen
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Nasal Drug Delivery Systems: An Overview [PDF]
, 2015 Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R. +3 more
core +1 more source
Pharmaceutics, 2020 Direct nose-to-brain delivery has been raised as a non-invasive powerful strategy to deliver drugs to the brain bypassing the blood-brain barrier (BBB). This study aimed at preparing and characterizing an innovative composite formulation, associating the
Thomas Adnet +10 more
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A selective role for neuronal activity regulated pentraxin in the processing of sensory-specific incentive value [PDF]
, 2007 Neuronal activity regulated pentraxin (Narp) is a secreted neuronal product which clusters AMPA receptors and regulates excitatory synaptogenesis. Although Narp is selectively enriched in brain, its role in behavior is not known.
Baraban, Jay M +6 more
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Nose-To-Brain Delivery of PLGA-Diazepam Nanoparticles [PDF]
AAPS PharmSciTech, 2015 The objective of the present investigation was to optimize diazepam (Dzp)-loaded poly(lactic-co-glycolic acid) nanoparticles (NP) to achieve delivery in the brain through intranasal administration. Dzp nanoparticles (DNP) were formulated by nanoprecipitation and optimized using Box-Behnken design. The influence of various independent process variables (
Deepak, Sharma +6 more
openaire +2 more sources
Nose-to-brain delivery of antiviral drugs: A way to overcome their active efflux? [PDF]
, 2018 Although several viruses can easily infect the central nervous system (CNS), antiviral drugs often show dramatic difficulties in penetrating the brain from the bloodstream since they are substrates of active efflux transporters (AETs). These transporters,
Dalpiaz, Alessandro, Pavan, Barbara
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Evaluation of Recent Intranasal Drug Delivery Systems to the Central Nervous System
Pharmaceutics, 2022 Neurological diseases continue to increase in prevalence worldwide. Combined with the lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a significant and growing burden on healthcare systems and societies.
Tyler P. Crowe, Walter H. Hsu
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Selective disruption of stimulus-reward learning in glutamate receptor gria 1 knockout mice. [PDF]
, 2003 Glutamatergic neurotransmission via AMPA receptors has been an important focus of studies investigating neuronal plasticity. AMPA receptor glutamate receptor 1 (GluR1) subunits play a critical role in long-term potentiation (LTP).
Mead, Andy N, Stephens, David N
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Nose-to-brain delivery of tacrine
Journal of Pharmacy and Pharmacology, 2007 Abstract In the treatment of Alzheimer's disease tacrine, a cholinesterase inhibitor, is not the drug of choice due to its low oral bioavailability, extensive hepatic first-pass effect, rapid clearance from the systemic circulation, pronounced hepatotoxicity, and the availability of drugs better than tacrine in the same pharmacological ...
Viral V, Jogani +4 more
openaire +2 more sources
Acta Pharmaceutica Sinica B, 2021 The management of the central nervous system (CNS) disorders is challenging, due to the need of drugs to cross the blood‒brain barrier (BBB) and reach the brain. Among the various strategies that have been studied to circumvent this challenge, the use of
Cláudia Pina Costa +3 more
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