Results 171 to 180 of about 3,656 (193)

Investigation into the role of the RNA methyltransferase NSun2 in neuroplasticity regulation [PDF]

, 2019
George, Harry
core  

Nsun2 Knockdown Alleviates Asthma Progression by Inhibiting Hnrnpk Expression Through Decreased 5-Methylcytosine. [PDF]

J Inflamm Res
Wu F, Zhao J.
europepmc   +1 more source

Coronaviruses reprogram the tRNA epitranscriptome to favor viral protein expression. [PDF]

Nat Commun
Muscolino E, Puig-Torrents M, Buigues Bisquert J, Correa Mendonca D, Talló-Parra M, Perez-Vilaro G, Caño-Prades O, Meehan GR, Kerr K, Herder V, Chillón M, Castello A, Sanjuan R, Patel AH, Díez J.   +14 more
europepmc   +1 more source

NSUN-Mediated m5C RNA Modification in Stem Cell Regulation. [PDF]

Cells
Moon J, Lee H, Jang Y, Kim SK.
europepmc   +1 more source

Correction to 'mRNA turnover dynamics are affected by cell differentiation and loss of the cytosine methyltransferase Nsun2'. [PDF]

Nucleic Acids Res
europepmc   +1 more source

Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs

Nucleic Acids Research, 2019
ABSTRACTPost-transcriptional modifications in mitochondrial tRNAs (mt-tRNAs) play critical roles in mitochondrial protein synthesis, which produces respiratory chain complexes. In this study, we used mass spectrometric analysis to map 5-methylcytidine (m5C) at positions 48–50 in eight mouse and six human mt-tRNAs.
Shinichi Nakagawa, Fan-Yan Wei, Kazuhito Tomizawa   +2 more
exaly   +3 more sources

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NSUN2 gene rs13181449 C>T polymorphism reduces neuroblastoma risk

Gene, 2023
Neuroblastoma is the most common tumor in infants. RNA m5C modification regulates the survival, differentiation, and migration of cells affecting RNA function. However, the effects of the m5C modification methyltransferase gene NSUN2 polymorphism on neuroblastoma susceptibility have not been reported.
Lei, Lin, Changmi, Deng, Chunlei, Zhou, Xinxin, Zhang, Jinhong, Zhu, Jiabin, Liu, Haiyan, Wu, Jing, He   +7 more
openaire   +2 more sources

NSUN2-Mediated m5C Methylation Impairs Endometrial Receptivity

Laboratory Investigation
Impaired endometrial decidualization is the primary cause of recurrent implantation failure (RIF). RNA methylation modification, especially NSUN family mediated m5C, is crucial for various physiological events, such as maternal-to-zygotic transition, gametogenesis, embryonic development, organismal lifespan, and cell cycle.
Jiafeng Lu, Ming Zhang, Zhenxing Liu, Ling Guo, Peng Huang, Wenjuan Xia, Jincheng Li, Jinghuan Lv, Hoi-Hung Cheung, Chenyue Ding, Hong Li, Boxian Huang   +11 more
openaire   +2 more sources

ETV4/NSUN2 Axis modulates aerobic glycolysis and malignancy in HSCC

Human Molecular Genetics
Abstract This study delves into the molecular intricacies of hypopharyngeal squamous cell carcinoma (HSCC), specifically focusing on the pivotal role played by ETS translocation variant 4 (ETV4) in aerobic glycolysis. The objective is to uncover new targets for early diagnosis and treatment of HSCC.
Xiaoxu Ding, Xueyan Zhang, Panxia Fang, Weiliang Bai   +3 more
openaire   +2 more sources

mRNA methylation by NSUN2 in cell proliferation

WIREs RNA, 2016
Methylation is a prevalent post‐transcriptional modification that occurs in almost all RNA species. NSUN2, a nucleolar RNA methyltransferase, has been shown to methylate mRNAs encoding factors that control cell division and growth arrest, thereby affecting their stability and/or translation.
openaire   +2 more sources