Results 181 to 190 of about 3,656 (193)

NSUN2-mediated RNA methylation: Molecular mechanisms and clinical relevance in cancer

Cellular Signalling
Cancer remains a leading cause of morbidity and mortality worldwide, necessitating the ongoing investigation of molecular targets for improved diagnosis, prognosis, and therapy. Among these targets, RNA modifications, particularly N5-methylcytosine (m5C) in RNA, have emerged as critical regulators of gene expression and cellular functions. NOP2/Sun RNA
Penghui, Li, Di, Huang
openaire   +2 more sources

NSun2 regulates aneurysm formation by promoting autotaxin expression and T cell recruitment

Cellular and Molecular Life Sciences, 2020
Abdominal aortic aneurysm (AAA) is characterized by inflammatory cell infiltration and aggravated by hyperhomocysteinemia (HHcy). It is unknown whether the homocysteine (Hcy)-activated RNA methyltransferase NOP2/Sun domain family member 2 (NSun2) is associated with AAA.
Yutong Miao, Yang Zhao, Lulu Han, Xiaolong Ma, Jiacheng Deng, Juan Yang, Silin Lü, Fangyu Shao, Wei Kong, Wengong Wang, Qingbo Xu, Xian Wang, Juan Feng   +12 more
openaire   +3 more sources

NSUN2 is critical for mouse oocyte meiosis and early embryonic development

Reproduction
In brief The mechanism by which the NSUN2 mutation causes female infertility is still unclear. This study reveals the role and potential mechanism of NSUN2 in mouse oocyte maturation and early embryonic development, and provides a resource for elucidating female infertility with NSUN2 mutations.
Tengteng Xu, Min Gao, Ling Zhang, Tianqi Cao, Yanling Qiu, Simiao Liu, Wenlian Wu, Yitong Zhou, Haiying Liu, Rui Zhang, Xiaohong Ruan, Junjiu Huang   +11 more
openaire   +2 more sources

LncRNA HOST2 promotes NSUN2-mediated breast cancer progression via interaction with ELAVL1

Cellular Signalling
Breast cancer (BC) is the most prevalent malignant tumor in women worldwide with high morbidity and mortality. NSUN2, a crucial RNA methyltransferase, plays a pivotal role in regulating the proliferation and metastasis of tumor cells. Our study demonstrated that NSUN2 is upregulated in BC tissues and cell lines, and its high expression is associated ...
Xuehui, Wang, Diya, Liu, Kaiyao, Hua, Lin, Fang   +3 more
openaire   +2 more sources

NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance

Cell Metabolism, 2023
Che-Chia Hsu, Hui-Kuan Lin, TINGJIN CHEN
exaly  

Chemical Proteomic Discovery of Isotype‐Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2

Angewandte Chemie - International Edition, 2023
Yongfeng Tao, Jan G Felber, Zhongyu Zou
exaly  

5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader

Cell Research, 2017
Ying Yang, Baofa Sun, Yu-Sheng Chen
exaly  

NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1

Circulation Research, 2016
Juan Feng, Qingbo Xu, Wengong Wang
exaly  

NSun2 promotes cell migration through methylating autotaxin mRNA

Journal of Biological Chemistry, 2020
Xin Xu, Junjie Zhang
exaly  

The tRNA methyltransferase NSun2 stabilizes p16INK4 mRNA by methylating the 3′-untranslated region of p16

Nature Communications, 2012
Jie Yi, Myriam Gorospe, Wengong Wang
exaly