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Current Biology, 2003 What are they? Nuclear pore complexes (NPCs) are often referred to as the ‘gatekeepers of the nucleus’, being responsible for regulating the molecular traffic – from ions to ribosomes – between the nucleoplasm and the cytoplasm. A typical vertebrate nucleus has about 5,000 NPCs scattered over its surface.What do they look like? A picture is worth twice
Wozniak, Richard W, Lusk, C.Patrick
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Cargo transport through the nuclear pore complex at a glance
Journal of Cell Science, 2021 Bidirectional transport of macromolecules across the nuclear envelope is a hallmark of eukaryotic cells, in which the genetic material is compartmentalized inside the nucleus.
G. Paci, Joana Caria, E. Lemke
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Acta Neuropathologica Communications, 2021 Nuclear pore complex injury has recently emerged as an early and significant contributor to familial and sporadic ALS disease pathogenesis. However, the molecular events leading to this pathological phenomenon characterized by the reduction of specific ...
Alyssa N. Coyne, Jeffrey D. Rothstein
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Characterization of nuclear pore complex targeting domains in Pom152 in Saccharomyces cerevisiae
Biology Open, 2021 Pom152 is a transmembrane protein within the nuclear pore complex (NPC) of fungi that is important for NPC assembly and structure. Pom152 is comprised of a short amino-terminal region that remains on the cytosolic side of the nuclear envelope (NE) and ...
Jacqueline T. Brown +3 more
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Pore timing: the evolutionary origins of the nucleus and nuclear pore complex [PDF]
F1000Research, 2019 The name “eukaryote” is derived from Greek, meaning “true kernel”, and describes the domain of organisms whose cells have a nucleus. The nucleus is thus the defining feature of eukaryotes and distinguishes them from prokaryotes (Archaea and Bacteria ...
Mark C. Field, Michael P. Rout
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The Nuclear Pore Complex as a Transcription Regulator.
Cold Spring Harbor Perspectives in Biology, 2021 The nuclear pore complex (NPC) is a highly conserved channel in the nuclear envelope that mediates mRNA export to the cytosol and bidirectional protein transport.
M. Sumner, Jason H. Brickner
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Types of nuclear localization signals and mechanisms of protein import into the nucleus
Cell Communication and Signaling, 2021 Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus.
Juane Lu +6 more
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Baculovirus Nuclear Import: Open, Nuclear Pore Complex (NPC) Sesame
Viruses, 2013 Baculoviruses are one of the largest viruses that replicate in the nucleus of their host cells. During infection, the rod-shape, 250-nm long nucleocapsid delivers its genome into the nucleus.
Wei Wu, Shelly Au, Nelly Panté
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Energetics of Transport through the Nuclear Pore Complex. [PDF]
PLoS ONE, 2016 Molecular transport across the nuclear envelope in eukaryotic cells is solely controlled by the nuclear pore complex (NPC). The NPC provides two types of nucleocytoplasmic transport: passive diffusion of small molecules and active chaperon-mediated ...
Ali Ghavami +2 more
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Nature Communications, 2020 In yeast, collapsed forks shift to the nuclear periphery to associate with two distinct perinuclear anchorage sites such as the nuclear pore complex. Here, the authors reveal the mechanisms engaged at nuclear pore complex facilitating fork integrity and ...
Karol Kramarz +7 more
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