Results 61 to 70 of about 623,335 (318)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Revealing the pure confinement effect in glass-forming liquids by dynamic mechanical analysis [PDF]
Phys. Rev. B 81, 024202 (2010), 2010 Many molecular glass forming liquids show a shift of the glass transition Tg to lower temperatures when the liquid is confined into mesoporous host matrices. Two contrary explanations for this effect are given in literature: First, confinement induced acceleration of the dynamics of the molecules leads to an effective downshift of Tg increasing with ...
arxiv +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Regulation of diverse nuclear shapes: pathways working independently, together
Communicative & Integrative Biology, 2021 Membrane-bound organelles provide physical and functional compartmentalization of biological processes in eukaryotic cells. The characteristic shape and internal organization of these organelles is determined by a combination of multiple internal and ...
Pallavi Deolal, Krishnaveni Mishra
doaj +1 more source
Statistical mechanics of a polymer chain attached to the interface of a cone-shaped channel [PDF]
, 2017 A polymer chain confined in nano-scale geometry has been used to investigate the underlying mechanism of Nuclear Pore Complex (NPC), where transport of cargoes is directional. It was shown here that depending on the solvent quality (good or poor) across the channel, a polymer chain can be either inside or outside the channel or both.
arxiv +1 more source
Controlling capillary fingering using pore size gradients in disordered media [PDF]
Physical Review Fluids 4, 084303 (2019), 2019 Capillary fingering is a displacement process that can occur when a non-wetting fluid displaces a wetting fluid from a homogeneous disordered porous medium. Here, we investigate how this process is influenced by a pore size gradient. Using microfluidic experiments and computational pore-network models, we show that the non-wetting fluid displacement ...
arxiv +1 more source
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
In situ architecture of the algal nuclear pore complex
Nature Communications, 2018 While the architecture of vertebrate nuclear pore complexes (NPCs) is well understood, the extent of its evolutionary conservation is still unclear.
Shyamal Mosalaganti +10 more
doaj +1 more source
The Role of Nucleoporins in Cardiac Tissue Development and Disease
Frontiers in Bioscience-Landmark, 2023 Nuclear pore complexes (NPCs) are intricate intracellular structures composed of approximately 30 nuclear pore proteins (NUPs) that regulate the transport of materials between the nucleus and cytoplasm in eukaryotic cells.
Xiaocong Chen, Rui Shi, Yu Luo, Liang Xu
doaj +1 more source