Results 141 to 150 of about 2,216,606 (233)

Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology

Neurobiology of Disease
Alterations in transactivating response region DNA-binding protein 43 (TDP-43) are prevalent in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurological disorders.
Constance Zhou, Evelyn J. Hardin, Till S. Zimmer, Stephanie Jackvony, Daniel Barnett, Noopur Khobrekar, Elisa Giacomelli, Lorenz Studer, Adam L. Orr, Anna G. Orr   +9 more
doaj   +1 more source

A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control.

PLoS Genetics, 2017
How cells control the overall size and growth of membrane-bound organelles is an important unanswered question of cell biology. Fission yeast cells maintain a nuclear size proportional to cellular size, resulting in a constant ratio between nuclear and ...
Kazunori Kume, Helena Cantwell, Frank R Neumann, Andrew W Jones, Ambrosius P Snijders, Paul Nurse   +5 more
doaj   +1 more source

ARHI (DIRAS 3), an Imprinted Tumor Suppressor Gene, Binds to Importins, and Blocks Nuclear Translocation of Stat3 [PDF]

, 2008
ARHI (DIRAS3) is an imprinted tumor suppressor gene whose expression is lost in the majority of breast and ovarian cancers. Unlike its homologs Ras and Rap, ARHI functions as a tumor suppressor.
In Soon Chang, Ke Zhang, Robert Bast, Jr., Robert Luo, Shaoyi Huang, Tao Tao, Warren Liao, Wenbo Lin, Xiaomin Chen, Yiling Lu, Yinhua Yu, Zhen Lu   +11 more
core   +1 more source

MASTL Promotes Hepatocellular Carcinoma Progression and Paclitaxel Resistance Through Mitotic Catastrophe

Cancer Science, Volume 117, Issue 2, Page 377-392, February 2026.
MASTL drives hepatocellular carcinoma (HCC) progression and paclitaxel resistance by triggering mitotic catastrophe. Depletion of MASTL induces DNA damage and promotes mitotic catastrophe, leading to cell death in HCC. MASTL‐mediated mitotic catastrophe depends on PP2A‐B55α activity, suggesting a novel therapeutic target for overcoming chemotherapy ...
Ke Wang, Ziwei Fu, Chuan Xiong, Jing Zhang, Qiang Luo   +4 more
wiley   +1 more source

Alterations in the nucleocytoplasmic transport in apoptosis: Caspases lead the way

Cell Proliferation, 2018
Apoptosis is a mode of regulated cell death that is indispensable for the morphogenesis, development and homeostasis of multicellular organisms. Caspases are cysteine‐dependent aspartate‐specific proteases, which function as initiators and executors of ...
G. Kopeina, Evgeniia A. Prokhorova, I. Lavrik, B. Zhivotovsky   +3 more
semanticscholar   +1 more source

Structural Basis of Targeting the Exportin CRM1 in Cancer

Cells, 2015
Recent studies have demonstrated the interference of nucleocytoplasmic trafficking with the establishment and maintenance of various cancers. Nucleocytoplasmic transport is highly regulated and coordinated, involving different nuclear transport factors ...
Achim Dickmanns, Thomas Monecke, Ralf Ficner   +2 more
doaj   +1 more source

CDK12 Inactivation Attenuates Prostate Cancer Progression by Inhibiting BNIP3‐Mediated Mitophagy

Cell Proliferation, Volume 59, Issue 2, February 2026.
In response to enzalutamide, damaged mitochondria are targeted for mitophagic degradation through the binding of BNIP3 to LC3, forming autophagosomes that are subsequently transported to lysosomes for degradation. These self‐protective mechanisms promote mitochondrial renewal, reduce oxidative stress and finally contribute to cancer cell survival ...
Mengjun Huang, Hanqi Lei, Tongyu Tong, Hailin Zou, Binyuan Yan, Fei Cao, Yiting Wang, Qiliang Teng, Bin Xu, Juan Luo, Yupeng Guan, Shaohong Lai, Peng Li, Jun Pang   +13 more
wiley   +1 more source

The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus

The FEBS Journal, Volume 293, Issue 3, Page 894-917, February 2026.
The plant hormone ethylene regulates plant growth, ripening, senescence, and stress responses. The hormonal signal transmission, from receptors at the ER membrane to the transcriptional regulators in the nucleus, is still not completely understood.
Fabian Wynen, Jan Eric Maika, Raphael Josef Eberle, Nina Jahnke, Marcel Wiermer, Laura Hartmann, Rüdiger Simon, Georg Groth   +7 more
wiley   +1 more source

EgRBP42 from oil palm enhances adaptation to stress in Arabidopsis through regulation of nucleocytoplasmic transport of stress-responsive mRNAs.

Plant, Cell and Environment, 2019
Abiotic stress reduces plant growth and crop productivity. However, the mechanism underlying posttranscriptional regulations of stress response remains elusive.
W. Yeap, P. Namasivayam, Tony Eng Keong Ooi, D. Appleton, H. Kulaveerasingam, C. Ho   +5 more
semanticscholar   +1 more source

Nuclear Envelope Permeability Barrier as a Fast‐Response Intracellular Mechanostat

Advanced Science, 2019
The nuclear envelope is an undisputed component of the intracellular mechanotransduction cascades which collect, process, and respond to mechanical stimuli from the environment.
Victor Shahin, Ivan U. Kouzel, Gonzalo Rosso, Ivan Liashkovich   +3 more
doaj   +1 more source