Results 91 to 100 of about 2,433 (185)
Alopecia as an Early Clinical Marker for Azathioprine Induced Myelosuppression: A Case Report [PDF]
Azathioprine is a pro-drug and is metabolized by the TPMT enzyme in the body. In South Asians, Azathioprine is known to cause alopecia and bone marrow suppression in patients with TPMT enzyme deficiency.
Babu, Dr. M Suresh, , Professor +3 more
core +2 more sources
Impacto de la mutación homocigota en Nudix hidrolasa 15 sobre la mielosupresión con 6-mercaptopurina en una niña europea con leucemia linfoblástica aguda: A propósito de un caso [PDF]
, 2023 A 6-year-old girl diagnosed with intermediate-risk acute lymphoblastic leukemia (ALL) presented with severe myelotoxicity and multiple infections during phase IB induction treatment with 6-mercaptopurine (6-MP).
García-Fumero, Ricardo +5 more
core +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 89-100, January 2026.This study assessed the use of 35 pharmacogenomic (PGx) medications listed in the Royal College of Pathologists of Australasia (RCPA) guideline, estimated the potential costs of subsidizing PGx testing in Australia, and predicted related prescribing changes.
Bella D. Ianni +3 more
wiley +1 more source
Dermatology and Therapy, 2020 Introduction Azathioprine is a synthetic purine analogue derived from 6-mercaptopurine which acts by disrupting nucleic acid synthesis and interfering with T cell activation. It is effective in dermatology diseases related to the immune system.
Po-Wei Huang +2 more
doaj +1 more source
Association between NUDT15 polymorphisms and thiopurineinduced leukopenia in pediatric acute lymphoblastic leukemia patients: a systematized review [PDF]
聖路加国際大学修士(公衆衛生学 ...
AKASHI, Airi, 赤司, 藍理
core +1 more source
BMC Gastroenterology, 2023 Background Thiopurines continue to play an important role in the treatment of inflammatory bowel disease (IBD). It is well known that thiopurines can cause several adverse reactions.
Shizuka Suzuki +13 more
doaj +1 more source
Identification and expression analysis of peroxisome-targeted defence proteins mediating innate immunity in the model plant Arabidopsis thaliana [PDF]
, 2011 Master's thesis in Biological ChemistryPeroxisomes are single-membrane organelles that have oxidative metabolic functions. Peroxisomes carry out major functions such as lipid degradation, photorespiration and glyoxylate cycle. However, new functions have
Mwaanga, Chimuka
core
Ten years of Genome Medicine. [PDF]
, 2019 This year marks the 10th anniversary of Genome Medicine. The journal was launched to meet the need in the community for a platform to publish impactful and open science that advances basic and clinical research—using genetic, genomic, omic, and systems ...
Auffray, C +4 more
core +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 241-254, January 2026.Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Roman Tremmel +13 more
wiley +1 more source
Frontiers in Pharmacology, 2019 Nudix Hydrolase 15 (NUDT15) and Thiopurine S-Methyltransferase (TPMT) are strong genetic determinants of thiopurine toxicity in pediatric acute lymphoblastic leukemia (ALL) patients.
Yoomi Park +11 more
doaj +1 more source