Results 81 to 90 of about 2,433 (185)
Scientific Reports, 2021 This study aimed to investigate the influence of TPMT*3C, ITPA, NUDT15, and 6-thioguanine nucleotides (6-TGN) on azathioprine (AZA)-induced myelosuppression in Southwest China patients with autoimmune hepatitis (AIH). A total of 113 Chinese patients with
Qiang Miao +7 more
doaj +1 more source
In silico druggability assessment of the NUDIX hydrolase protein family as a workflow for target prioritization [PDF]
, 2020 Computational chemistry has now been widely accepted as a useful tool for shortening lead times in early drug discovery. When selecting new potential drug targets, it is important to assess the likelihood of finding suitable starting points for lead ...
Almlöf, I. +8 more
core +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.ABSTRACT Azathioprine (AZA), a widely used immunosuppressant, can induce acute pancreatitis (AP), yet the underlying molecular mechanisms remain unclear. This study employed an integrative multiomics strategy—combining network toxicology, machine learning, Mendelian randomization (MR), and molecular docking—to elucidate the biological basis of AZA ...
Zhijun Xie +4 more
wiley +1 more source
مجلة جامعة دمشق للعلوم الطبية, 2021 Background and Aims: NUDT15 genetic polymorphism is known to be associated with frequent hematopoietic toxicities during acute lymphoblastic leukemia (ALL) mercaptopurine therapy.
محمد ماجد محمد
doaj
Current Oncology, 2022 Surgical resection remains the only curative treatment strategy for Pancreatic Ductal Adenocarcinoma (PDAC). A proportion of patients succumb to early disease recurrence post-operatively despite receiving adjuvant chemotherapy.
Daniel Llwyd Hughes +4 more
doaj +1 more source
NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine [PDF]
Cancer Research, 2016 Abstract Thiopurines are a standard treatment for childhood leukemia, but like all chemotherapeutics, their use is limited by inherent or acquired resistance in patients. Recently, the nucleoside diphosphate hydrolase NUDT15 has received attention on the basis of its ability to hydrolyze the thiopurine effector metabolites 6-thio ...
Valerie NC +12 more
openaire +4 more sources
Clinician Satisfaction With Pharmacogenomics Clinical Services at a Multistate Health System
Clinical and Translational Science, Volume 19, Issue 3, March 2026.ABSTRACT Pharmacogenomics (PGx) utilizes genetic information to optimize medication management. Barriers to PGx implementation include limited confidence and knowledge in applying results, time constraints, and financial barriers. Clinical services across health systems vary greatly with differing consultative PGx service models.
Kristen Jacobsen +4 more
wiley +1 more source
Frontiers in Pharmacology, 2018 The aim of this study was to investigate the influence of NUDT15 R139C, thiopurine S-methyltransferase (TPMT), and 6-TGN on azathioprine (AZA) induced leukopenia in Chinese autoimmune patients. Among 87 enrolled patients, 23 (26.4%) had leukopenia.
Xiang Fei +8 more
doaj +1 more source
مجلة جامعة دمشق للعلوم الطبية, 2022 خلفية البحث وهدفه: يعد دواء المركابتوبورين mercaptopurine (6MP) حجر الأساس في علاج مرضى الابيضاض اللمفاوي الحاد ولاسيما في مرحلة الصيانة. إن الهدف من عرض هذه الحالة هو إيضاح أسباب تطور تثبيط نقوي شديد عند مريضة مشخص لها ابيضاض لمفاوي حاد ولاسيما ...
محمد محمد, ماهر سيفو
doaj
The Nudix Hydrolase 15 (NUDT15) Gene Variants among Jordanian Arab Population [PDF]
Asian Pacific Journal of Cancer Prevention, 2019 Background: Nudix Hydrolase 15 gene (NUDT15) encodes nucleotide triphosphate diphosphatase which metabolizes the purine analog drugs, such as anticancer thiopurine and anti-gout allopurinol. Genetic variants on Nudix Hydrolase 15 gene (NUDT15) gene effects the drug’s hydrolyses and hence increases the susceptibility to drug-induced toxicity. The NUDT15
Jarrar, Yazun Bashir, Ghishan, Maria
openaire +2 more sources