Results 101 to 110 of about 6,789 (241)
Prognostic Significance of Bile Duct Loss in Early‐Stage Primary Biliary Cholangitis: A Long‐Term Observational Study
Hepatology Research, Volume 55, Issue 12, Page 1621-1630, December 2025.Bile duct loss on liver biopsy predicts future liver‐related events in early‐stage primary biliary cholangitis, even in patients with preserved liver function. This finding highlights the prognostic value of histological bile duct assessment at diagnosis and may guide early risk stratification and management decisions.Taiki Okumura, Takefumi Kimura, Takanobu Iwadare, Shun‐Ichi Wakabayashi, Hiroyuki Kobayashi, Yuki Yamashita, Satoru Joshita, Michiharu Komatsu, Naoki Tanaka, Akihiro Matsumoto, Tomoyuki Nakajima, Mai Iwaya, Masahiro Umemura, Kazuhito Kawata, Kenichi Harada, Takeji Umemura +15 morewiley +1 more sourceMolecular Mechanisms of Nonalcoholic Fatty Liver Disease: Potential Role for 12-Lipoxygenase [PDF]
, 2017 Nonalcoholic fatty liver disease (NAFLD) is a spectrum of pathologies associated with fat accumulation in the liver. NAFLD is the most common cause of liver disease in the United States, affecting up to a third of the general population.Anderson, Ryan M., Chalasani, Naga, Mirmira, Raghavendra G., Samala, Niharika, Tersey, Sarah A. +4 morecore +1 more sourceGanoderic Acid A Alleviates High‐Fat Diet‐Induced Lipid Metabolism Disorders in Mice by Inhibiting Intestinal Farnesoid X Receptor
Food Frontiers, Volume 6, Issue 6, Page 3108-3121, November 2025.Ganoderic acid A (GA) improved lipid metabolism disorders by inhibiting intestinal FXR. GA markedly suppressed the ileal intestinal FXR activity. Then, GA changed bile acid composition and upregulated hepatic Cyp7a1 mRNA through decreasing FXR target genes encoded protein levels.Feng Lu, Shanshan Ju, Yi Ying, Jihan Liu, Chengfeng Yang, Min Li, Hong Zhou, Baoxue Yang +7 morewiley +1 more sourceBenzoxazole Derivatives as Potent FXR and PPARα Dual Agonists With Anti‐Fibrotic and Metabolic Regulatory Effects
MedComm, Volume 6, Issue 11, November 2025.MHY5396, a benzoxazole derivative, functions as a potent dual FXR and PPARα agonist. It exhibits significant anti‐fibrotic and metabolic regulatory effects, effectively improving liver and kidney fibrosis in experimental models. These findings highlight its potential as a therapeutic candidate for fibrosis and metabolic disorders.Mi‐Jeong Kim, Dong‐Gyun Han, Hyeon Seo Park, Sugyeong Ha, Sang Gyun Noh, Jeongwon Kim, Ji‐an Yoo, Byeong Moo Kim, Khas‐Erdene Battogtokh, Soohwan Oh, Youngmi Jung, Youngsuk Jung, Hae Young Chung, Hyung Ryong Moon, In‐Soo Yoon, Ki Wung Chung +15 morewiley +1 more sourceAcute-on-chronic liver failure in cirrhosis [PDF]
, 2016 The definition of acute-on-chronic liver failure (ACLF) remains contested. In Europe and North America, the term is generally applied according to the European Association for the Study of the Liver-Chronic Liver Failure (EASL-CLIF) Consortium guidelines,Arroyo, V, Fernandez, J, Garcia-Tsao, G, Gines, P, Jalan, R, Kamath, PS, Moreau, R, Nevens, F, Schnabl, B, To, U +9 morecore Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial [PDF]
, 2019 Background Non-alcoholic steatohepatitis (NASH) is a common type of chronic liver disease that can lead to cirrhosis. Obeticholic acid, a farnesoid X receptor agonist, has been shown to improve the histological features of NASH.Abdelmalek, Manal, Abdelmalek, Manal F, Abrams, Gary, Aguilar, Humberto, Ahmed, Aijaz, Aigner, Elmar, Aithal, Guruprasad, Al-Shamma, Sfa, Ala, Aftab, Alazawi, William, Albillos, Agustin, Allison, Michael, Andrade, Raul, Andreone, Pietro, Angelico, Mario, Ankoma-Sey, Victor, Anstee, Quentin, Anstee, Quentin M, Anty, Rodolphe, Araya, Victor, Arenas Ruiz, Juan Ignacio, Arkkila, Perttu, Arora, Marty, Asselah, Tarik, Au, Jennifer, Ayonrinde, Oyekoya, Bailey, Robert James, Balakrishnan, Maya, Bambha, Kiran, Bansal, Meena, Barritt, Sidney, Bate, John, Beato, Jorge, Beckebaum, Susanne, Beckebaum, Susanne, Bedossa, Pierre, Behari, Jaideep, Bellot, Pablo, Ben Ari, Ziv, Bennett, Michael, Berenguer, Marina, Beretta-Piccoli, Benedetta Terziroli, Berg, Thomas, Bonacini, Maurizio, Bonet, Lucia, Borg, Brian, Bourliere, Marc, Boursier, Jerome, Boursier, Jerome, Bowman, William, Bradley, David, Brankovic, Marija, Braun, Marius, Bronowicki, Jean-Pierre, Bruno, Savino, Bugianesi, Elisabetta, Bugianesi, Elisabetta, Cai, Cindy, Calleja Panero, José Luis, Campagna, Jason, Carey, Elizabeth, Carmiel, Michal, Carrión, Jose Antonio, Cave, Matthew, Chagas, Cristina, Chami, Tawfik, Chang, Alan, Coates, Allan, Cobbold, Jeremy, Corey, Kathleen, Corless, Lynsey, Cortez-Pinto, Helena, Cortez-Pinto, Helena, Crespo, Javier, Cruz Pereira, Oscar, de Ledinghen, Victor, deLemos, Andrew, Diago, Moises, Dufour, Jean-Francois, Dufour, Jean-François, Dugalic, Predrag, Dunn, Winston, Elkhashab, Magby, Epstein, Michael, Escudero-Garcia, Maria Desamparados, Etzion, Ohad, Evans, Larry, Falcone, Robert, Fernandez, Conrado, Ferreira, Jose, Fink, Scott, Finnegan, Kevin, Firpi-Morell, Roberto, Floreani, Annarosa, Fontanges, Thierry, Ford, Ryan, Forrest, Ewan, Fowell, Andrew, Fracanzani, Anna Ludovica, Francque, Sven, Freilich, Bradley, Frias, Juan, Fuchs, Michael, Fuentes, Javier, Galambos, Michael, Gallegos, Juan, Geerts, Anja, Geier, Andreas, Geier, Andreas, George, Jacob, Ghali, Maged, Ghalib, Reem, Gholam, Pierre, Gines, Pere, Gitlin, Norman, Gluud, Lise Lotte, Gluud, Lise Lotte, Goeser, Tobias, Goff, John, Goodman, Zachary, Gordon, Frederic, Gordon, Stuart, Goria, Odile, Graupera, Isabel, Greer, Shaun, Grigorian, Alla, Gronbaek, Henning, Guillaume, Maeva, Gunaratnam, Naresh, Halegoua-De Marzio, Dina, Hameed, Bilal, Hametner, Stephanie, Hamilton, James, Harrison, Stephen, Harrison, Stephen, Hartleb, Marek, Hassanein, Tarek, Hellstern, Paul, Herring, Robert, Heurich, Eva, Hezode, Christophe, Hinrichsen, Holger, Holland Fischer, Peter, Horsmans, Yves, Huang, Jonathan, Häussinger, Dieter, Jakiche, Antoine, Jeffers, Lennox, Jones, Blake, Jorge, Rosa, Jorquera, Francisco, Kahraman, Alisan, Kaita, Kelly, Karyotakis, Nicholas, Kayali, Zeid, Kechagias, Stergios, Kepczyk, Thomas, Khalili, Mandana, Khallafi, Hicham, Kluwe, Johannes, Knapple, Whitfield, Knapple, Whitfield, Kohli, Anita, Korenblat, Kevin, Kowdley, Kris, Kowdley, Kris V, Krag, Aleksander, Krause, Richard, Kremer, Andreas, Krok, Karen, Krstic, Miodrag, Kugelmas, Marcelo, Kumar, Sonal, Labarriere, Damien, Lai, Michelle, Lampertico, Pietro, Lawitz, Eric, Lawitz, Eric, Lee, Alice, Leroy, Vincent, Lidofsky, Steven, Lim, Joseph, Lim, Tina Huey, Lipkis, Donald, Little, Ester, Lonardo, Amadeo, Long, Michelle, Loomba, Rohit, Loomba, Rohit, Lurie, Yoav, MacConell, Leigh, Macedo, Guilherme, Makara, Mihály, Maliakkal, Benedict, Manns, Michael, Manousou, Pinelopi, Mantry, Parvez, Marchesini, Giulio, Marinho, Carla, Marotta, Paul, Marschall, Hanns-Ulrich, Mathurin, Philippe, Mathurin, Philippe, Mayo, Marlyn, Mazzella, Giuseppe, Mazzella, Giuseppe, McCullen, Mark, McLaughlin, William, Merriman, Raphael, Modi, Apurva, Molina, Esther, Montano-Loza, Aldo, Montano-Loza, Aldo J, Monteverde, Carlos, Moreea, Sulleman, Moreno, Christophe, Morisco, Filomena, Mubarak, Abdullah, Muellhaupt, Beat, Mukherjee, Sandeep, Muller, Kate, Müller, Tobias, Nagorni, Aleksandar, Naik, Jahnavi, Neff, Guy, Nevah, Moises, Newsome, Philip, Newsome, Philip N, Nguyen-Khac, Eric, Noureddin, Mazen, Oben, Jude, Olveira, Antonio, Olveira, Antonio, Orlent, Hans, Orr, David, Orr, David, Orr, James, Ortiz-Lasanta, Grisell, Ozenne, Violaine, Pandya, Prashant, Paredes, Angelo, Park, James, Patel, Joykumar, Patel, Keyur, Patton, Heather, Peck-Radosavljevic, Markus, Petta, Salvatore, Pianko, Stephen, Piekarska, Anna, Pimstone, Neville, Pockros, Paul, Pol, Stanislas, Porayko, Michael, Poulos, John, Pound, David, Pouzar, Joe, Presa Ramos, Jose, Pyrsopoulos, Nikolaos, Rafiq, Nila, Ramji, Alnoor, Ratziu, Vlad, Ratziu, Vlad, Ravinuthala, Ravi, Reddy K G, Gautham, Reddy K R, K. Rajender, Reddy, Chakradhar, Regenstein, Frederic, Reindollar, Robert, Riera, Andres, Rinella, Mary, Rinella, Mary, Rivera Acosta, Jose, Robaeys, Geert, Roberts, Stuart, Rodriguez-Perez, Federico, Romero-Gomez, Manuel, Rubin, Raymond, Rumi, Mariagrazia, Rushbrook, Simon, Rust, Christian, Ryan, Michael, Safadi, Rifaat, Said, Adnan, Salminen, Kimmo, Samuel, Didier, Santoro, John, Sanyal, Arun, Sanyal, Arun J, Sarkar, Souvik, Schaeffer, Cynthia, Schattenberg, Jörn, Schiefke, Ingolf, Schiff, Eugene, Schmidt, Wolfgang, Schneider, Jeffrey, Schouten, Jeoffrey, Schultz, Michael, Sebastiani, Giada, Semela, David, Sepe, Thomas, Shapiro, David, Sheikh, Aasim, Sheikh, Muhammad, Sheikh, Muhammad Y, Sheridan, David, Sheridan, David, Sherman, Kenneth, Shibolet, Oren, Shiffman, Mitchell, Shringarpure, Reshma, Siddique, Asma, Sieberhagen, Cyril, Sigal, Samuel, Sikorska, Katarzyna, Simon, Krzysztof, Sinclair, Marie, Skoien, Richard, Solis, Joel, Sood, Siddharth, Souder, Bob, Spivey, James, Stal, Per, Stinton, Laura, Strasser, Simone, Svorcan, Petar, Szabo, Gyongzi, Talal, Andrew, Tam, Edward, Tetri, Brent, Thuluvath, Paul, Tobias, Hillel, Tomasiewicz, Krzysztof, Torres, Dawn, Trauner, Michael, Trautwein, Christian, Trotter, James, Trotter, James, Tsochatzis, Emanuel, Unitt, Esther, Uta, Merle, Vargas, Victor, Varkonyi, Istvan, Veitsman, Ella, Vespasiani Gentilucci, Umberto, Victor, David, Vierling, John, Vincent, Catherine, Vincze, Aron, von der Ohe, Manfred, Von Roenn, Natasha, Vuppalanchi, Raj, Waters, Michael, Watt, Kymberly, Weltman, Martin, Wieland, Amanda, Wiener, Gregory, Williams A, Alonzo, Williams J, Jeffrey, Wilson, Jason, Yataco, Maria, Yoshida, Eric, Younes, Ziad, Younossi, Zobair M, Yuan, Liyun, Zaru, Luna, Zivony, Adam, Zogg, Donald, Zoller, Heinz, Zoulim, Fabien, Zuckerman, Eli, Zuin, Massimo +370 morecore +1 more sourceCombination of fibrates with obeticholic acid is able to normalise biochemical liver tests in patients with difficult‐to‐treat primary biliary cholangitis
, 2021 Pierre‐Antoine Soret, Laurent Lam, Fabrice Carrat, Lena Smets, Thomas Berg, Marco Carbone, Pietro Invernizzi, Vincent Leroy, Palak Trivedi, Nora Cazzagon, Christina Weiler‐Normann, Laurent Alric, Isabelle Rosa, Alexandra Heurgué, Jean‐Paul Cervoni, Jérôme Dumortier, Pascal Potier, Olivier Roux, Christine Silvain, Christophe Bureau, Rodolphe Anty, Dominique Larrey, Cynthia Levy, Albert Parés, Christoph Schramm, Frederik Nevens, Olivier Chazouillères, Christophe Corpechot +27 moreopenalex +2 more sourcesPregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in earlyand late-stage cholestasis [PDF]
, 2017 AIM:
To ascertain whether cholestasis affects the expression of two CYP3A isoforms (CYP3A1 and CYP3A2) and of pregnane X receptor (PXR) and constitutive androstane receptor (CAR).Albertoni, Laura, Baldo, Vincenzo, Baldovin, Tatjana, Carrara, Maria, DALLA POZZA, Arianna, De Martin, Sara, Floreani, Annarosa, Gabbia, Daniela, Lazzari, Roberta, Zigiotto, Giorgia +9 morecore +1 more source
