Results 61 to 70 of about 6,789 (241)

Effects of Intestinal FXR-Related Molecules on Intestinal Mucosal Barriers in Biliary Tract Obstruction

Frontiers in Pharmacology, 2022
Background: The farnesoid X receptor (FXR) is a key factor regulating hepatic bile acid synthesis and enterohepatic circulation. Repression of bile acid synthesis by the FXR is a potential strategy for treating cholestatic liver disease.
Meng Yan, Meng Yan, Li Hou, Yaoyao Cai, Hanfei Wang, Yujun Ma, Qiming Geng, Weiwei Jiang, Weibing Tang   +8 more
doaj   +1 more source

Prognostic Factors for Transplant-Free Survival and Validation of Prognostic Models in Chinese Patients with Primary Biliary Cholangitis Receiving Ursodeoxycholic Acid [PDF]

, 2017
OBJECTIVES: We aimed to validate the prognostic models for primary biliary cholangitis (PBC) in Chinese patients receiving ursodeoxycholic acid (UCDA), and to compare their performances in predicting the long-term survival. METHODS: Chinese patients with
Cheung, KS, Fung, JYY, Lai, CL, Seto, WKW, Yuen, RMF   +4 more
core   +1 more source

Obeticholic acid for the treatment of primary biliary cirrhosis [PDF]

Expert Review of Clinical Pharmacology, 2015
Primary biliary cirrhosis (PBC) is characterized by progressive nonsuppurative destruction of small bile ducts, resulting in intrahepatic cholestasis, fibrosis and ultimately end-stage liver disease. Timely intervention with ursodeoxycholic acid is associated with excellent survival, although approximately one-third of all patients fail to achieve ...
Palak J, Trivedi, Gideon M, Hirschfield, M Eric, Gershwin   +2 more
openaire   +2 more sources

Relationship Between Fecal Bile Acid Profile and Intestinal Microbiota in Patients With Chronic Radiation Enteritis

Journal of Digestive Diseases, EarlyView.
Patients with chronic radiation enteritis (CRE) demonstrate dysregulated bile acid (BA) metabolism, characterized by an increased proportion of primary BAs and a decreased proportion of secondary BAs. Moreover, the diversity of the intestinal microbiota is significantly reduced in individuals with CRE, and there is a bidirectional interaction between ...
Xin Shen, Song Bo Li, Meng Jie Gao, Jiao Jiao Cao, Hua Yang, Wei Wei Li, Li Chun Wei, Min Chen, Jun Ye Liu, Yong Quan Shi   +9 more
wiley   +1 more source

Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation. [PDF]

, 2017
This study aims to uncover how specific bacteria and bile acids (BAs) contribute to steatosis induced by diet and farnesoid X receptor (FXR) deficiency in both genders.
French, Samuel W, Gonzalez, Frank J, Jena, Prasant Kumar, Kalanetra, Karen M, Krishnan, Viswanathan V, Liu, Hui-Xin, Mills, David A, Sheng, Lili, Wan, Yu-Jui Yvonne   +8 more
core   +1 more source

Critical Role of microRNA-21 in the Pathogenesis of Liver Diseases [PDF]

, 2020
MicroRNAs are small non-coding RNAs that range in length from 18 to 24 nucleotides. As one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed in many mammalian cell types.
Han, Sen, Kusumanchi, Praveen, Liangpunsakul, Suthat, Yang, Zhihong, Zhang, Ting   +4 more
core   +1 more source

Development of NAFLD‐Specific Human Liver Organoid Models on a Microengineered Array Chip for Semaglutide Efficacy Evaluation

Cell Proliferation, EarlyView.
Microporous array organ chips were integrated with commercially available well plates to develop organoid chip platforms, which enable modelling of hepatic physiology and non‐alcoholic fatty liver disease (NAFLD) pathogenesis, as well as evaluation of semaglutide therapeutics. ABSTRACT Progressive non‐alcoholic fatty liver disease (NAFLD) may culminate
Xiao‐yan You, Xiang‐yang Li, Hui Wang, Guo‐ping Zhao   +3 more
wiley   +1 more source

Experimental Pharmacological Agents for the Treatment of Primary Biliary Cholangitis

Journal of Experimental Pharmacology, 2020
Annarosa Floreani1,2 1University of Padova, Padova, Italy; 2Scientific Institute for Research, Hospitalization and Healthcare, Negrar, Verona, ItalyCorrespondence: Annarosa FloreaniUniversity of Padova, Padova, ItalyTel +10393899418841Email annarosa ...
Floreani A
doaj  

Fine-tuning of SIRT1 expression is essential to protect the liver from cholestatic liver disease [PDF]

, 2019
Cholestasis comprises aetiologically heterogeneous conditions characterized by accumulation of bile acids in the liver that actively contribute to liver damage.
Banales, Jesus M, Beraza, Naiara, Blokker, Britt A, Echeandia, Marta, Fuchs, Claudia, Galduroz, Mikel, Gutierrez-de Juan, Virginia, Halilbasic, Emina, Le Gall, Gwenaelle, Maijo, Monica, Martínez-Chantar, María Luz, Mato, José M, Milkiewicz, Malgorzata, Milkiewicz, Piotr, Müller, Michael, Patterson, Angela M, Philo, Mark, Rushbrook, Simon M, Schungel, Rebecca, Ten, Anna, Trauner, Michael, Varela-Rey, Marta   +21 more
core   +3 more sources

Farnesoid X Receptor Agonist Treatment Alters Bile Acid Metabolism but Exacerbates Liver Damage in a Piglet Model of Short-Bowel SyndromeSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Options for the prevention of short-bowel syndrome–associated liver disease (SBS-ALDs) are limited and often ineffective. The farnesoid X receptor (FXR) is a newly emerging pharmaceutical target and FXR agonists have been shown to ...
Prue M. Pereira-Fantini, Susan Lapthorne, Cormac G.M. Gahan, Susan A. Joyce, Jenny Charles, Peter J. Fuller, Julie E. Bines   +6 more
doaj   +1 more source